Donate chemical probes

Everyone can donate a chemical probe. Probe candidates are subjected to a strict review process and must fulfil the following criteria:

• Potency < 100 nM (IC₅₀ or K_D)
• Selectivity within target family > 30-fold
• Good selectivity outside the target family
• Cellular on-target activity < 1 µM (IC₅₀ or K_D)
• 100-fold less potent control compound

DCP reviewing process

In order to guarantee the quality of the compounds all donated probe candidates and control compounds are subjected to a two-tier scientific review process: the first review takes place internally within the SGC Joint Management Committee, including partners who have not been involved in the probe project. The second review is performed by a panel of renowned scientists, the Donated Chemical Probe Scientific Committee, who act as independent reviewers. After approval DCPs are subjected to the PDSP screen and all data are added to the DCP database. Synthetic routes for probe and control compounds are shared with the chemical vendors Sigma, Tocris and Cayman, which make the compounds commercially available in order to maintain the resupply and sustainability of the chemical probes. Probes are also made openly available through the SGC (see the "How to order" section of the "FAQs").

Advantages

• Probe and control data are added to the ChEMBL database.
• Probe data are added to the Chemical Probes.org database.
• The compounds are used by reserachers worldwide which results in more citations of your publication(s).
• Probes and controls are proposed to the vendors Cayman, Sigma and Tocris.

If you would like to join the project and donate a probe, please contact the SGC Frankfurt.

Contact: frankfurt@thesgc.org