Target	Probe	Control	Targeted domain	Mode of action	Recommended concentration	Target origin
FNTB	ABT-100	A-108	Transferase domain	Inhibitor	0.01 - 1000 nM	human
GLS	A-446	A-426	Allosteric site at the dimer‐dimer interface	Inhibitor	100 nM	human
BCAT1, BCAT2	BAY-069	BAY-771	Substrate binding site	Inhibitor	1 µM	human
Complex I	BAY-179	BAY-070	Quinone binding site (MT-ND1, NDUFS2/7)	Inhibitor	0.1 - 1 µM	human
METAP2	BAY-277	BAY-8805	—	degrader	100 nM	human
SOS1	BAY-293	BAY-294	RAS GEF	Inhibitor	0.02 - 1.1 µM	human
PLA2G5	BAY-439	BAY-163	active site	Inhibitor	≤ 300 nM	human
ELANE	BAY-678	BAY-677	Protease domain	Inhibitor	≤ 1 µM	human
NUDT1	BAY-707	BAY-604	Active site	Inhibitor	0.001 - 1 µM	human
PDE9A	BAY-7081	BAY-7424	Lipophilic pocket	Inhibitor	1 µM	human
MMP12	BAY-7598	BAY-694	Protease domain	Inhibitor	< 10 nM	human
SLC2A1	BAY-876	BAY-588	—	Inhibitor	0.1 - 75 nM	human
ADAMTS7, ADAMTS12	BAY-9835	BAY-1880	Protease domain	Inhibitor	100 nM	human
HCV NS5B	BI 207127	BI-7656	Pocket 1 of the thumb domain	Inhibitor	≤ 100 nM	viral
HCV NS3	BI-1230	BI-1675	Protease domain, RNA helicase domain	Inhibitor	< 100 nM	viral
CTSS	BI-1915	BI-1920	—	Inhibitor	1 µM	human
EPHX2	BI-1935	BI-2049	catalytic domain	Inhibitor	< 1 nM	human
CMA1	BI-1942	no record.controls	Protease domain	Inhibitor	1 µM	human
HIV NNRT	BI-2540	BI-2439	Allosteric site adjacent to the polymerase active site	Inhibitor	≤ 100 nM	viral
ENPP2	BI-2545	BI-3017	Catalytic domain	Inhibitor	1 µM	human
HSD17B13	BI-3231	BI-0955	Ser172, Tyr185 (catalytical triad)	Inhibitor	1 µM	human
MMP13	BI-4394	BI-4395	Protease domain	Inhibitor	0.1 µM	human
ELANE	BI-5524	BI-5525	—	Inhibitor	100 nM	human
ALOX5AP	BI 665915	BI-0153	Membrane domain	Inhibitor	30 – 500 nM	human
FASN	BI 99179	BI 99990	Ketoacyl Reductase domain	Inhibitor	1 -10 µM	human
KRAS	ACBI3	cis-ACBI3	—	PROTAC degrader	1-10 µM	human
DHODH	IPP/CNRS-A017	IPP/CNRS-A019	—	Inhibitor	≤ 100 nM	human
MGLL	JNJ-42226314	JNJ-8034	Azetidine-amide carbonyl forms H-bonds with NH of Ala51 and Met123 in oxyanion hole	Non-covalent, competitive, reversible inhibitor	≤ 10 µM	human
OGA	JNJ-65355394	JNJ-73924149	—	Agonist or Inhibitor	≤ 10 µM	human
PDE10A	JNJ-42396302	JNJ-40573663	Hydrophobic clamp of the catalytic site	Inhibitor	≤ 10 µM	human
PDE2A	JNJ-54082730	JNJ-54103985	Catalytic site	Inhibitor	None	human
RSV L	JNJ-8003	JNJ-6643	Induced-fit pocket on capping domain	Inhibitor	1 - 10 µM	viral
SMOX	JNJ-9350	JNJ-4545	—	Inhibitor	≤ 10 µM	human
UCHL1	8RK64	JYQ88	Active site (covalent binding to Cys90)	Covalent inhibitor	≤ 3 µM	human
USP32	Huib32	Huib32NC	Active site (covalent binding to Cys743)	Covalent, fast reversible Inhibitor	5 µM	human
PARK7	JYQ-173	MB078	Active site (covalent binding to Cys106)	Covalent inhibitor	≤ 1 µM	human
Gamma secretase complex	GSM1	GSM-NC	—	Modulator	≤ 1 µM	human
Gamma secretase complex	MRK-560	GSI-NC	Protease domain	Inhibitor	≤ 100 nM	human
FKBP5	SAFit2	ddSAFit2, 18(S)-Me	FKBP-type domain 1 (Phe67)	Inhibitor	≥ 5 µM	human
CYP11B2	MSD-CYP11B2	MSD-CYP11B2 Negative control	—	Inhibitor	25 - 100 nM	human
PDE10A	THPP-1	THPP-1-NC	Active site	Inhibitor	100 nM	human
MALT1	NVS-MALT1	NVS-MALT1-C	Interface between caspase and Ig3 domains	Allosteric inhibitor	1 µM	human
FAAH	PF-04457845	PF-04875474	Active site (covalent binding to Ser241)	Covalent inhibitor	0.2 - 1 µM	human
VNN1	PFI-653	PFI-653-N	Near catalytic site	Inhibitor	≤ 1 µM	human
MIF	BTZO-1	BTZO-4	Tautomerase domain	ARE Activator	0.8 - 1 µM	human
MMP13	T-26c	T-26f	Protease domain	Inhibitor	100 nM	human
METAP2	TP-004	TPn-004	—	Inhibitor	0.2 - 1 µM	human
MGAT2	TP-020	TP-020n	—	Inhibitor	1 - 10 µM	human
OGA	TP-040	TP-040n	Hydrophobic deep pocket (Tyr219, Trp278)	Inhibitor	≤ 10 µM	human
UGCG	TP-060	TP-060n	—	Allosteric inhibitor (Noncompetitive against UDP-glucose)	≤ 1 µM	human