ABT-100
| Target | FNTB |
| Targeted domain | Transferase domain |
| Mode of action | Inhibitor |
| Control | A-108 |
| Recommended cellular usage concentration | 0.01 - 1000 nM |
| In vivo use | yes |
| Synonyms | A-409100 |
| Donated by | Abbvie |
Probe criteria
| Inhibitor/agonist potency: goal is < 100 nM (IC50, Kd) | Surpasses criterion: Human FNTB: IC50 = 0.05 nM (SPA) |
| Selectivity within target family: > 30-fold | Surpasses criterion: >100 000-fold selective for FNTB over the closely related enzyme PGGT1B (GGTase I) |
| Selectivity outside target family | Surpasses criterion: No activity in panel of 75 off-targets @10 µM; closest hit: phencyclidine PCP receptor IC50 = 3 μM; clean PDSP scan |
| On target cell activity for cell-based targets: goal is < 1 µM IC50/EC50 | Surpasses criterion: 0.73 nM (NIH 3T3 Ras); no activity on PGGT1B substrate Rap1A up to 3µM |
| Control compound (100 times less potent than the probe) | Surpasses criterion: A-108: Bovine FNTB: IC50 >100 nM; Shows activity on SIGMAR1 (pKi = 7.04) in the PDSP scan. |