Potency data for probe ABT-100 and control A-108
In vitro potency
| Target name | Target information | Species | Assay description | ABT-100 | A-108 | Publication of assay conditions |
|---|---|---|---|---|---|---|
| FNTB | Homo sapiens | Scintillation proximity assay (SPA) | IC50 = 0.05 nM ± 0.010 nM (n=6) | PMID: 16222147 | ||
| FNTB | Bos taurus | Scintillation proximity assay (SPA) | IC50 > 100 nM |
In cell potency
| Target name | Target information | Species | Assay description | ABT-100 | A-108 | Publication of assay conditions |
|---|---|---|---|---|---|---|
| FNTB | NIH 3T3 Ras | Homo sapiens | Immunoblot method to monitor prenylation inhibition of Ras | EC50 = 0.73 nM ± 0.090 nM (n=3) | PMID: 16222147 |