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IPP/CNRS-A017

2D structure
Target DHODH 
Mode of action Inhibitor
Control IPP/CNRS-A019
Recommended cellular usage concentration ≤ 100 nM
In vivo use No
Synonyms 18d, DHODH-IN-1
Donated by IPP/CNRS


Probe criteria


Inhibitor/agonist potency: goal is < 100 nM (IC50, Kd>/sub>) Surpasses criterion: IC50= 25 nM (activity assay)
Selectivity within target family: > 30-fold Surpasses criterion: No related human family members.
Selectivity outside target family PDSP screen (44 targets): Closest off-targets at 10 µM are GABA/ PBR (KD =2.1 µM), ADRA1D (KD = 4.1 µM) and TMEM97 (KD = 583 nM)
PDSP GPCR screen: Closest off-targets are TMEM97 (83.71 % inhibition), ADRA2A (77.67 % inhibition), GABA/PBR (62.49 % inhibition) and ADRB3 (Ki = 5327.21 nM).
Clean KINOMEscan.
On target cell activity for cell-based targets: goal is < 1 µM IC50/EC50 Surpasses criterion: IC50 = 2.5 nM (HEK293 measle assay)
Control compound (100 times less potent than the probe) Surpasses criterion: IC50 = 1.2 µM (measles assay) (480 fold); Clean PDSP scan except for one hit: TMEM97 (Ki = 5252.78 nM)