Potency data for probe IPP/CNRS-A017 and control IPP/CNRS-A019
In vitro potency
| Target name | Target information | Species | Assay description | IPP/CNRS-A017 | IPP/CNRS-A019 | Publication of assay conditions |
|---|---|---|---|---|---|---|
| DHODH | human recombinant | Homo sapiens | Activity assay: 2,6-Dichlorophenolindophenol reducion measurement | IC50 = 25 nM ± 5.000 nM | PMID: 26079043 |
In cell potency
| Target name | Target information | Species | Assay description | IPP/CNRS-A017 | IPP/CNRS-A019 | Publication of assay conditions |
|---|---|---|---|---|---|---|
| DHODH | HEK-293T cells infected with rMV2/Luc | Homo sapiens | Measles Virus Inhibition Assay: A recombinant vaccine strain of measles virus expressing firefly luciferase (rMV2/Luc) unit was used for determination of the antiviral activity. | IC50 = 2.5 nM | IC50 = 1.2 µM | PMID: 26079043 |
| DHODH | Jurkat T lymphocyte cell line | Homo sapiens | Inhibition of T cell proliferation in Jurkat cells: CellTiter-Glo | IC50 = 20 nM | PMID: 26079043 |