Potency data for probe BAY-386 and control BAY-448
In vitro potency
| Target name | Target information | Species | Assay description | BAY-386 | BAY-448 | Publication of assay conditions |
|---|---|---|---|---|---|---|
| F2R | Homo sapiens | Binding assay (platelet membranes) | IC50 = 56 nM |
In cell potency
| Target name | Target information | Species | Assay description | BAY-386 | BAY-448 | Publication of assay conditions |
|---|---|---|---|---|---|---|
| F2R | Homo sapiens | Functional cellular assay (HEK cells) (F2R) | IC50 = 10 nM | IC50 > 10 µM | ||
| F2RL3 | Homo sapiens | Functional cellular assay (HEK cells) (F2RL3) | IC50 > 10 µM | IC50 > 5 µM | ||
| Homo sapiens | Inhibition of platelet aggregation (human plasma, TRAP-6) (IC50) | IC50 = 0.43 µM | ||||
| Homo sapiens | Inhibition of platelet aggregation (human plasma, TRAP-6) (IC90) | IC90 = 0.68 µM | ||||
| Homo sapiens | Inhibition of platelet aggregation (human plasma, ADP, Collagen) | IC50 > 100 µM | ||||
| Homo sapiens | Inhibition of platelet aggregation (human plasma, thrombin) | IC50 = 0.14 µM | ||||
| Homo sapiens | Inhibition of platelet aggregation (human plasma, TRAP-6) | IC50 > 10 µM |