Potency data for probe BAY-549 and control BAY-4900
In vitro potency
| Target name | Target information | Species | Assay description | BAY-549 | BAY-4900 | Publication of assay conditions |
|---|---|---|---|---|---|---|
| ROCK1 | Homo sapiens | Biochemical ROCK1 assay | IC50 = 0.6 nM | |||
| ROCK2 | Homo sapiens | Biochemical ROCK2 assay | IC50 = 1.1 nM | IC50 = 17.7 µM | PMID: 18973168 |
In cell potency
| Target name | Target information | Species | Assay description | BAY-549 | BAY-4900 | Publication of assay conditions |
|---|---|---|---|---|---|---|
| Oryctolagus cuniculus | Mechanistic tissue assay (arteria saphena rabbit) | IC50 = 65 nM | PMID: 18973168 |