Potency data for probe BI-2545 and control BI-3017
In vitro potency
| Target name | Target information | Species | Assay description | BI-2545 | BI-3017 | Publication of assay conditions |
|---|---|---|---|---|---|---|
| ENPP2 | Homo sapiens | Biochemical assay: measurement of LPA (human): RapidFire-MS-based analysis | IC50 = 2.2 nM ± 1.000 nM (n=3) | IC50 = 8.9 µM | PMID: 29259743 | |
| ENPP2 | Rattus sp. | Biochemical assay: measurement of LPA (rat): RapidFire-MS-based analysis | IC50 = 3.4 nM ± 2.100 nM (n=2) | PMID: 29259743 |
In cell potency
| Target name | Target information | Species | Assay description | BI-2545 | BI-3017 | Publication of assay conditions |
|---|---|---|---|---|---|---|
| ENPP2 | Homo sapiens | Whole blood assay: measurement of LPA (human): RapidFire-MS-based analysis | IC50 = 29 nM ± 5.000 nM (n=2) | PMID: 29259743 | ||
| ENPP2 | Rattus sp. | Whole blood assay: measurement of LPA (rat): RapidFire-MS-based analysis | IC50 = 96 nM ± 32.600 nM (n=2) | PMID: 29259743 |