Potency data for probe BI 653048 and control BI-3047
In vitro potency
| Target name | Target information | Species | Assay description | BI 653048 | BI-3047 | Publication of assay conditions |
|---|---|---|---|---|---|---|
| NR3C1 | Homo sapiens | Fluorescence polarization assay: Measurement of the competition for binding to the receptor between a test compound and a fluorescently labeled receptor probe. | IC50 = 55 nM | IC50 > 2 µM | PMID: 25516791 |
In cell potency
| Target name | Target information | Species | Assay description | BI 653048 | BI-3047 | Publication of assay conditions |
|---|---|---|---|---|---|---|
| IL6 | Homo sapiens | Fibroblast IL-6 assay: Tests the ability of the compound to inhibit the production of IL-6 by human foreskin fibroblasts following stimulation by IL-1 in vitro. | IC50 = 23 nM | PMID: 25516791 |