Potency data for probe FS-694 and control FM-743
No in vitro potency data available.
In cell potency
| Target name | Target information | Species | Assay description | FS-694 | FM-743 | Publication of assay conditions |
|---|---|---|---|---|---|---|
| MAPK14 | Homo sapiens | Biochemical assay: ELISA, cell free | IC50 = 0.2 nM ± 0.100 nM (n=3) | PMID: 28834431 | ||
| MAPK14, MAPK14 | HEK cells; full length | Homo sapiens | NanoBRET (MAPK14) | IC50 = 14.9 nM | IC50 = 11.3 µM | PMID: 31702918 |
| MAPK11, MAPK11 | HEK cells | Homo sapiens | NanoBRET (MAPK11) | IC50 = 16.9 nM | IC50 = 16.2 µM | PMID: 31702918 |
| HSPB1 | Homo sapiens | Inhibition of HSP27 (Ser82) (Western blot) | IC50 < 1 µM | |||
| TNF | Homo sapiens | TNF-α release ( LPS stim., WB) | IC50 = 38 nM ± 1.100 nM (n=4) | PMID: 28834431 |