Potency data for probe MSD-M1PAM and control MSD-M1PAM-NC
In vitro potency
| Target name | Target information | Species | Assay description | Compound conc. | Probe result (SD) | Control result (SD) | Publication of assay conditions |
|---|---|---|---|---|---|---|---|
| CHRM1 | CHONFATcells expressing human mAChR1 receptor | Homo sapiens | Fold potentiation assay | Potentiation inflection point = 136 nM | Potentiation inflection point > 10000 µM | PMID: 24900430 | |
| PTPN2 | Homo sapiens | Panlabs assay | 10 µM | IC50 = 10 µM |
In cell potency
| Target name | Target information | Species | Assay description | Probe result (SD) | Control result (SD) | Publication of assay conditions |
|---|---|---|---|---|---|---|
| CHRM1 | Homo sapiens | Agonism inflection point assay | Agonism inflection point = 7379 nM |