Potency data for probe PPTN and control PPTN-NC
In vitro potency
| Target name | Target information | Species | Assay description | PPTN | PPTN-NC | Publication of assay conditions |
|---|---|---|---|---|---|---|
| P2RY14 | Pan troglodytes | Binding assay (no HSA) | Ki = 2.3 nM (n=10) | Ki = 8614 nM (n=1) | PMID: 21689930 | |
| P2RY14 | Pan troglodytes | Binding assay with 2% HSA | Ki = 35 nM | Ki > 100 µM (n=1) | PMID: 21689930 |
In cell potency
| Target name | Target information | Species | Assay description | PPTN | PPTN-NC | Publication of assay conditions |
|---|---|---|---|---|---|---|
| P2RY14 | Pan troglodytes | FLIPR assay | IC50 = 0.5 nM (n=14) | IC50 = 4381 nM (n=4) | ||
| MAPK14 | Homo sapiens | NanoBRET (SGC Frankfurt) (MAPK14) | IC50 > 20 µM (n=1) |