Potency data for probe (R)-9s and control (S)-9s
In vitro potency
| Target name | Target information | Species | Assay description | (R)-9s | (S)-9s | Publication of assay conditions |
|---|---|---|---|---|---|---|
| ADRA1D | Homo sapiens | Binding assay (ADRA1D) | Ki = 1.6 nM (n=3) | Ki = 130 nM (n=3) | PMID: 26954848 | |
| ADRA1A | Homo sapiens | Binding assay (ADRA1A) | Ki > 2700 nM (n=3) | PMID: 26954848 | ||
| ADRA1B | Homo sapiens | Binding assay (ADRA1B) | Ki > 1200 nM (n=3) | PMID: 26954848 |
In cell potency
| Target name | Target information | Species | Assay description | (R)-9s | (S)-9s | Publication of assay conditions |
|---|---|---|---|---|---|---|
| rat bladder strips | Rattus sp. | Inhibition of phenylephrine-induced contractions in bladder strips from rats with bladder outlet obstruction | IC30 = 15 nM | PMID: 26954848 |