Donated Chemical Probes

Selectivity data for probe BTZO-1 and control BTZO-4

BTZO-1

Compound concentration: 10 µM

Receptor	HGNC target name	Inhibition [%] (Primary experimental value)	Ki [nM] (Secondary experimental value)	pKi
5-HT1A	HTR1A	9.69
5-HT1B	HTR1B	-1.90
5-HT1D	HTR1D	-10.24
5-HT1E	HTR1E	-1.13
5-HT2A	HTR2A	-11.22
5-HT2B	HTR2B	34.32
5-HT2C	HTR2C	12.25
5-HT3	HTR3A	17.18
5-HT5A	HTR5A	-10.22
5-HT6	HTR6	-1.33
5-HT7A	HTR7	-11.32
D1	DRD1	3.24
D2	DRD2	22.85
D3	DRD3	13.57
D4	DRD4	10.06
D5	DRD5	21.48
SERT	SLC6A4	-10.20
NET	SLC6A2	-0.36
DAT	SLC6A3	-3.83
MOR	OPRM1	3.52
DOR	OPRD1	4.81
KOR	OPRK1	1.65
GABAA		6.23
H1	HRH1	-14.85
H2	HRH2	24.41
H3	HRH3	2.00
H4	HRH4	-0.98
Alpha1A	ADRA1A	-12.51
Alpha1B	ADRA1B	9.84
Alpha2A	ADRA2A	0.13
Alpha2B	ADRA2B	16.99
Alpha2C	ADRA2C	-9.43
Beta1	ADRB1	-8.56
Beta2	ADRB2	-12.92
M1	CHRM1	-5.27
M2	CHRM2	5.18
M3	CHRM3	-12.48
M4	CHRM4	-11.99
M5	CHRM5	-7.50
Beta3	ADRB3	20.10
GABAA/BZP		55.86	934.00	6.00
GABA/PBR		9.91
Alpha1D	ADRA1D	-17.25
Sigma 2	TMEM97	12.50
Sigma 1	SIGMAR1	14.00

BTZO-4

Compound concentration: 10 µM

Receptor	HGNC target name	Inhibition [%] (Primary experimental value)
5-HT1A	HTR1A	24.71
5-HT1B	HTR1B	12.32
5-HT1D	HTR1D	-4.84
5-HT1E	HTR1E	-0.38
5-HT2A	HTR2A	-12.26
5-HT2B	HTR2B	-5.37
5-HT2C	HTR2C	3.98
5-HT3	HTR3A	-1.17
5-HT5A	HTR5A	1.92
5-HT6	HTR6	-15.88
5-HT7A	HTR7	-5.10
D1	DRD1	7.77
D2	DRD2	-3.91
D3	DRD3	27.77
D4	DRD4	7.31
D5	DRD5	11.24
SERT	SLC6A4	-11.21
NET	SLC6A2	28.68
DAT	SLC6A3	-2.05
MOR	OPRM1	6.47
DOR	OPRD1	-0.62
KOR	OPRK1	4.68
GABAA		-11.46
H1	HRH1	49.86
H2	HRH2	24.76
H3	HRH3	8.10
H4	HRH4	1.89
Alpha1A	ADRA1A	-9.97
Alpha1B	ADRA1B	-5.82
Alpha2A	ADRA2A	12.70
Alpha2B	ADRA2B	-5.58
Alpha2C	ADRA2C	-4.89
Beta1	ADRB1	-1.52
Beta2	ADRB2	-13.91
M1	CHRM1	-11.61
M2	CHRM2	13.65
M3	CHRM3	-13.50
M4	CHRM4	-4.70
M5	CHRM5	0.56
Beta3	ADRB3	32.37
GABAA/BZP		6.34
GABA/PBR		22.63
Alpha1D	ADRA1D	-18.48
Sigma 2	TMEM97	-19.04
Sigma 1	SIGMAR1	-10.90

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Primary results are shown as '% Ctrl', i.e. the negative control (DMSO) is equal 100% control and the positive control (control compound) is equal 0% control. For compounds showing less than 50% of control in the primary screening assay, a Kd will be determined. Note: It cannot be excluded that 0 % control values are due to assay artefacts.

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Jump to control KinomeScan data

BTZO-1

HGNC target name	DiscoverX gene symbol of kinase	% Control	Compound Concentration [nM]	Kd [nM]
AAK1	AAK1	100.0	1000
ABL1	ABL1-phosphorylated	89.0	1000
ABL2	ABL2	87.0	1000
ACVR1	ACVR1	79.0	1000
ACVR1B	ACVR1B	100.0	1000
ACVR2A	ACVR2A	91.0	1000
ACVR2B	ACVR2B	100.0	1000
ACVRL1	ACVRL1	99.0	1000
COQ8A	ADCK3	88.0	1000
COQ8B	ADCK4	60.0	1000
AKT1	AKT1	100.0	1000
AKT2	AKT2	100.0	1000
AKT3	AKT3	100.0	1000
ALK	ALK(L1196M)	93.0	1000
PRKAA1	AMPK-alpha1	100.0	1000
PRKAA2	AMPK-alpha2	100.0	1000
ANKK1	ANKK1	100.0	1000
NUAK1	ARK5	100.0	1000
MAP3K5	ASK1	75.0	1000
MAP3K6	ASK2	71.0	1000
AURKA	AURKA	87.0	1000
AURKB	AURKB	82.0	1000
AURKC	AURKC	97.0	1000
AXL	AXL	100.0	1000
BMP2K	BIKE	86.0	1000
BLK	BLK	88.0	1000
BMPR1A	BMPR1A	100.0	1000
BMPR1B	BMPR1B	75.0	1000
BMPR2	BMPR2	100.0	1000
BMX	BMX	98.0	1000
BRAF	BRAF(V600E)	100.0	1000
PTK6	BRK	100.0	1000
BRSK1	BRSK1	91.0	1000
BRSK2	BRSK2	100.0	1000
BTK	BTK	96.0	1000
BUB1	BUB1	100.0	1000
CAMK1	CAMK1	92.0	1000
PNCK	CAMK1B	56.0	1000
CAMK1D	CAMK1D	90.0	1000
CAMK1G	CAMK1G	100.0	1000
CAMK2A	CAMK2A	100.0	1000
CAMK2B	CAMK2B	100.0	1000
CAMK2D	CAMK2D	90.0	1000
CAMK2G	CAMK2G	96.0	1000
CAMK4	CAMK4	97.0	1000
CAMKK1	CAMKK1	96.0	1000
CAMKK2	CAMKK2	90.0	1000
CASK	CASK	84.0	1000
CDK11B	CDC2L1	100.0	1000
CDK11A	CDC2L2	94.0	1000
CDK13	CDC2L5	75.0	1000
CDK19	CDK11	86.0	1000
CDK2	CDK2	96.0	1000
CDK3	CDK3	99.0	1000
CDK4	CDK4-cyclinD3	90.0	1000
CDK5	CDK5	85.0	1000
CDK7	CDK7	69.0	1000
CDK8	CDK8	36.0	1000	> 10000.0
CDK9	CDK9	95.0	1000
CDKL1	CDKL1	87.0	1000
CDKL2	CDKL2	76.0	1000
CDKL3	CDKL3	88.0	1000
CDKL5	CDKL5	100.0	1000
CHEK1	CHEK1	85.0	1000
CHEK2	CHEK2	100.0	1000
CIT	CIT	100.0	1000
CLK1	CLK1	99.0	1000
CLK2	CLK2	80.0	1000
CLK3	CLK3	96.0	1000
CLK4	CLK4	90.0	1000
CSF1R	CSF1R-autoinhibited	95.0	1000
CSK	CSK	100.0	1000
CSNK1A1	CSNK1A1	76.0	1000
CSNK1A1L	CSNK1A1L	100.0	1000
CSNK1D	CSNK1D	81.0	1000
CSNK1E	CSNK1E	88.0	1000
CSNK1G1	CSNK1G1	96.0	1000
CSNK1G2	CSNK1G2	74.0	1000
CSNK1G3	CSNK1G3	100.0	1000
CSNK2A1	CSNK2A1	68.0	1000
CSNK2A2	CSNK2A2	92.0	1000
MATK	CTK	100.0	1000
DAPK1	DAPK1	100.0	1000
DAPK2	DAPK2	86.0	1000
DAPK3	DAPK3	91.0	1000
DCLK1	DCAMKL1	90.0	1000
DCLK2	DCAMKL2	97.0	1000
DCLK3	DCAMKL3	97.0	1000
DDR1	DDR1	85.0	1000
DDR2	DDR2	100.0	1000
MAP3K12	DLK	100.0	1000
DMPK	DMPK	100.0	1000
CDC42BPG	DMPK2	80.0	1000
STK17A	DRAK1	100.0	1000
STK17B	DRAK2	80.0	1000
DYRK1A	DYRK1A	91.0	1000
DYRK1B	DYRK1B	100.0	1000
DYRK2	DYRK2	100.0	1000
EGFR	EGFR(T790M)	100.0	1000
EIF2AK1	EIF2AK1	97.0	1000
EPHA1	EPHA1	100.0	1000
EPHA2	EPHA2	100.0	1000
EPHA3	EPHA3	87.0	1000
EPHA4	EPHA4	100.0	1000
EPHA5	EPHA5	94.0	1000
EPHA6	EPHA6	100.0	1000
EPHA7	EPHA7	80.0	1000
EPHA8	EPHA8	78.0	1000
EPHB1	EPHB1	88.0	1000
EPHB2	EPHB2	100.0	1000
EPHB3	EPHB3	100.0	1000
EPHB4	EPHB4	100.0	1000
EPHB6	EPHB6	61.0	1000
ERBB2	ERBB2	65.0	1000
ERBB3	ERBB3	83.0	1000
ERBB4	ERBB4	96.0	1000
MAPK3	ERK1	80.0	1000
MAPK1	ERK2	91.0	1000
MAPK6	ERK3	73.0	1000
MAPK4	ERK4	100.0	1000
MAPK7	ERK5	100.0	1000
MAPK15	ERK8	100.0	1000
ERN1	ERN1	100.0	1000
PTK2	FAK	90.0	1000
FER	FER	94.0	1000
FES	FES	100.0	1000
FGFR1	FGFR1	100.0	1000
FGFR2	FGFR2	100.0	1000
FGFR3	FGFR3(G697C)	100.0	1000
FGFR4	FGFR4	73.0	1000
FGR	FGR	100.0	1000
FLT1	FLT1	100.0	1000
FLT3	FLT3-autoinhibited	98.0	1000
FLT4	FLT4	84.0	1000
FRK	FRK	100.0	1000
FYN	FYN	100.0	1000
GAK	GAK	97.0	1000
EIF2AK4	GCN2(Kin.Dom.2,S808G)	47.0	1000
GRK1	GRK1	76.0	1000
GRK2	GRK2	65.0	1000
GRK3	GRK3	51.0	1000
GRK4	GRK4	100.0	1000
GRK7	GRK7	89.0	1000
GSK3A	GSK3A	82.0	1000
GSK3B	GSK3B	74.0	1000
HASPIN	HASPIN	100.0	1000
HCK	HCK	94.0	1000
HIPK1	HIPK1	61.0	1000
HIPK2	HIPK2	76.0	1000
HIPK3	HIPK3	92.0	1000
HIPK4	HIPK4	85.0	1000
MAP4K1	HPK1	100.0	1000
HUNK	HUNK	81.0	1000
CILK1	ICK	83.0	1000
IGF1R	IGF1R	80.0	1000
CHUK	IKK-alpha	100.0	1000
IKBKB	IKK-beta	100.0	1000
IKBKE	IKK-epsilon	100.0	1000
INSR	INSR	100.0	1000
INSRR	INSRR	86.0	1000
IRAK1	IRAK1	100.0	1000
IRAK3	IRAK3	82.0	1000
IRAK4	IRAK4	100.0	1000
ITK	ITK	82.0	1000
JAK1	JAK1(JH2domain-pseudokinase)	86.0	1000
JAK2	JAK2(JH1domain-catalytic)	100.0	1000
JAK3	JAK3(JH1domain-catalytic)	100.0	1000
MAPK8	JNK1	100.0	1000
MAPK9	JNK2	100.0	1000
MAPK10	JNK3	100.0	1000
KIT	KIT-autoinhibited	97.0	1000
LATS1	LATS1	95.0	1000
LATS2	LATS2	79.0	1000
LCK	LCK	95.0	1000
LIMK1	LIMK1	84.0	1000
LIMK2	LIMK2	100.0	1000
STK11	LKB1	79.0	1000
STK10	LOK	99.0	1000
LRRK2	LRRK2(G2019S)	92.0	1000
LTK	LTK	99.0	1000
LYN	LYN	100.0	1000
MAP3K13	LZK	100.0	1000
MAK	MAK	89.0	1000
MAP3K1	MAP3K1	65.0	1000
MAP3K15	MAP3K15	100.0	1000
MAP3K2	MAP3K2	92.0	1000
MAP3K3	MAP3K3	77.0	1000
MAP3K4	MAP3K4	92.0	1000
MAP4K2	MAP4K2	100.0	1000
MAP4K3	MAP4K3	90.0	1000
MAP4K4	MAP4K4	100.0	1000
MAP4K5	MAP4K5	100.0	1000
MAPKAPK2	MAPKAPK2	100.0	1000
MAPKAPK5	MAPKAPK5	92.0	1000
MARK1	MARK1	100.0	1000
MARK2	MARK2	78.0	1000
MARK3	MARK3	89.0	1000
MARK4	MARK4	100.0	1000
MAST1	MAST1	73.0	1000
MAP2K1	MEK1	100.0	1000
MAP2K2	MEK2	89.0	1000
MAP2K3	MEK3	75.0	1000
MAP2K4	MEK4	100.0	1000
MAP2K5	MEK5	79.0	1000
MAP2K6	MEK6	100.0	1000
MELK	MELK	82.0	1000
MERTK	MERTK	82.0	1000
MET	MET(Y1235D)	100.0	1000
MINK1	MINK	83.0	1000
MAP2K7	MKK7	93.0	1000
MKNK1	MKNK1	89.0	1000
MKNK2	MKNK2	100.0	1000
MYLK3	MLCK	100.0	1000
MAP3K9	MLK1	85.0	1000
MAP3K10	MLK2	100.0	1000
MAP3K11	MLK3	100.0	1000
CDC42BPA	MRCKA	91.0	1000
CDC42BPB	MRCKB	100.0	1000
STK4	MST1	75.0	1000
MST1R	MST1R	100.0	1000
STK3	MST2	94.0	1000
STK24	MST3	100.0	1000
STK26	MST4	100.0	1000
MTOR	MTOR	100.0	1000
MUSK	MUSK	100.0	1000
MYLK	MYLK	67.0	1000
MYLK2	MYLK2	100.0	1000
MYLK4	MYLK4	87.0	1000
MYO3A	MYO3A	92.0	1000
MYO3B	MYO3B	79.0	1000
STK38	NDR1	76.0	1000
STK38L	NDR2	66.0	1000
NEK1	NEK1	100.0	1000
NEK10	NEK10	100.0	1000
NEK11	NEK11	100.0	1000
NEK2	NEK2	84.0	1000
NEK3	NEK3	72.0	1000
NEK4	NEK4	91.0	1000
NEK5	NEK5	78.0	1000
NEK6	NEK6	100.0	1000
NEK7	NEK7	75.0	1000
NEK9	NEK9	96.0	1000
MAP3K14	NIK	100.0	1000
NIM1K	NIM1	100.0	1000
NLK	NLK	100.0	1000
OXSR1	OSR1	100.0	1000
MAPK14	p38-alpha	94.0	1000
MAPK11	p38-beta	100.0	1000
MAPK13	p38-delta	99.0	1000
MAPK12	p38-gamma	58.0	1000
PAK1	PAK1	94.0	1000
PAK2	PAK2	100.0	1000
PAK3	PAK3	84.0	1000
PAK4	PAK4	86.0	1000
PAK6	PAK6	100.0	1000
PAK5	PAK7	87.0	1000
CDK16	PCTK1	100.0	1000
CDK17	PCTK2	100.0	1000
CDK18	PCTK3	94.0	1000
PDGFRA	PDGFRA	89.0	1000
PDGFRB	PDGFRB	83.0	1000
PDPK1	PDPK1	100.0	1000
CDPK1	PFCDPK1(P.falciparum)	77.0	1000
PK5	PFPK5(P.falciparum)	100.0	1000
CDK15	PFTAIRE2	75.0	1000
CDK14	PFTK1	100.0	1000
PHKG1	PHKG1	84.0	1000
PHKG2	PHKG2	77.0	1000
PIK3C2B	PIK3C2B	83.0	1000
PIK3C2G	PIK3C2G	100.0	1000
PIK3CA	PIK3CA(Q546K)	100.0	1000
PIK3CB	PIK3CB	100.0	1000
PIK3CD	PIK3CD	54.0	1000
PIK3CG	PIK3CG	100.0	1000
PI4KB	PIK4CB	71.0	1000
PIKFYVE	PIKFYVE	100.0	1000
PIM1	PIM1	85.0	1000
PIM2	PIM2	97.0	1000
PIM3	PIM3	100.0	1000
PIP5K1A	PIP5K1A	100.0	1000
PIP5K1C	PIP5K1C	84.0	1000
PIP4K2B	PIP5K2B	100.0	1000
PIP4K2C	PIP5K2C	98.0	1000
PRKACA	PKAC-alpha	91.0	1000
PRKACB	PKAC-beta	92.0	1000
PKMYT1	PKMYT1	100.0	1000
PKN1	PKN1	77.0	1000
PKN2	PKN2	100.0	1000
PKNB	PKNB(M.tuberculosis)	88.0	1000
PLK1	PLK1	100.0	1000
PLK2	PLK2	95.0	1000
PLK3	PLK3	82.0	1000
PLK4	PLK4	80.0	1000
PRKCD	PRKCD	100.0	1000
PRKCE	PRKCE	100.0	1000
PRKCH	PRKCH	98.0	1000
PRKCI	PRKCI	100.0	1000
PRKCQ	PRKCQ	90.0	1000
PRKD1	PRKD1	100.0	1000
PRKD2	PRKD2	97.0	1000
PRKD3	PRKD3	81.0	1000
PRKG1	PRKG1	100.0	1000
PRKG2	PRKG2	96.0	1000
EIF2AK2	PRKR	100.0	1000
PRKX	PRKX	100.0	1000
PRPF4B	PRP4	71.0	1000
PTK2B	PYK2	100.0	1000
SIK3	QSK	85.0	1000
RAF1	RAF1	100.0	1000
RET	RET(V804M)	100.0	1000
PIK3C3	VPS34	82.0	1000
RIOK1	RIOK1	85.0	1000
RIOK2	RIOK2	94.0	1000
RIOK3	RIOK3	99.0	1000
RIPK1	RIPK1	83.0	1000
RIPK2	RIPK2	82.0	1000
RIPK4	RIPK4	84.0	1000
DSTYK	RIPK5	88.0	1000
ROCK1	ROCK1	100.0	1000
ROCK2	ROCK2	94.0	1000
ROS1	ROS1	100.0	1000
RPS6KA4	RPS6KA4(Kin.Dom.2-C-terminal)	80.0	1000
RPS6KA5	RPS6KA5(Kin.Dom.2-C-terminal)	88.0	1000
RPS6KA1	RSK1(Kin.Dom.2-C-terminal)	100.0	1000
RPS6KA3	RSK2(Kin.Dom.2-C-terminal)	88.0	1000
RPS6KA2	RSK3(Kin.Dom.2-C-terminal)	100.0	1000
RPS6KA6	RSK4(Kin.Dom.2-C-terminal)	92.0	1000
RPS6KB1	S6K1	100.0	1000
SBK1	SBK1	100.0	1000
SGK1	SGK	99.0	1000
SBK3	SgK110	100.0	1000
SGK2	SGK2	85.0	1000
SGK3	SGK3	100.0	1000
SIK1	SIK	95.0	1000
SIK2	SIK2	86.0	1000
SLK	SLK	85.0	1000
NUAK2	SNARK	100.0	1000
SNRK	SNRK	100.0	1000
SRC	SRC	92.0	1000
SRMS	SRMS	87.0	1000
SRPK1	SRPK1	83.0	1000
SRPK2	SRPK2	100.0	1000
SRPK3	SRPK3	100.0	1000
STK16	STK16	83.0	1000
STK33	STK33	87.0	1000
STK35	STK35	79.0	1000
STK36	STK36	82.0	1000
STK39	STK39	100.0	1000
SYK	SYK	97.0	1000
MAP3K7	TAK1	78.0	1000
TAOK1	TAOK1	92.0	1000
TAOK2	TAOK2	73.0	1000
TAOK3	TAOK3	73.0	1000
TBK1	TBK1	91.0	1000
TEC	TEC	82.0	1000
TESK1	TESK1	84.0	1000
TGFBR1	TGFBR1	97.0	1000
TGFBR2	TGFBR2	100.0	1000
TIE1	TIE1	91.0	1000
TEK	TIE2	99.0	1000
TLK1	TLK1	93.0	1000
TLK2	TLK2	96.0	1000
TNIK	TNIK	83.0	1000
TNK1	TNK1	59.0	1000
TNK2	TNK2	100.0	1000
TNNI3K	TNNI3K	87.0	1000
NTRK1	TRKA	100.0	1000
NTRK2	TRKB	96.0	1000
NTRK3	TRKC	72.0	1000
TRPM6	TRPM6	77.0	1000
TSSK1B	TSSK1B	100.0	1000
TSSK3	TSSK3	86.0	1000
TTK	TTK	100.0	1000
TXK	TXK	81.0	1000
TYK2	TYK2(JH2domain-pseudokinase)	98.0	1000
TYRO3	TYRO3	80.0	1000
ULK1	ULK1	100.0	1000
ULK2	ULK2	100.0	1000
ULK3	ULK3	100.0	1000
KDR	VEGFR2	100.0	1000
VRK2	VRK2	74.0	1000
WEE1	WEE1	100.0	1000
WEE2	WEE2	100.0	1000
WNK1	WNK1	100.0	1000
WNK2	WNK2	100.0	1000
WNK3	WNK3	100.0	1000
WNK4	WNK4	100.0	1000
STK32A	YANK1	100.0	1000
STK32B	YANK2	100.0	1000
STK32C	YANK3	100.0	1000
YES1	YES	100.0	1000
STK25	YSK1	100.0	1000
MAP3K19	YSK4	86.0	1000
MAP3K20	ZAK	87.0	1000
ZAP70	ZAP70	100.0	1000

BTZO-4

HGNC target name	DiscoverX gene symbol of kinase	% Control	Compound Concentration [nM]	Kd [nM]
AAK1	AAK1	100.0	1000
ABL1	ABL1-phosphorylated	72.0	1000
ABL2	ABL2	85.0	1000
ACVR1	ACVR1	82.0	1000
ACVR1B	ACVR1B	99.0	1000
ACVR2A	ACVR2A	100.0	1000
ACVR2B	ACVR2B	100.0	1000
ACVRL1	ACVRL1	70.0	1000
COQ8A	ADCK3	98.0	1000
COQ8B	ADCK4	67.0	1000
AKT1	AKT1	89.0	1000
AKT2	AKT2	92.0	1000
AKT3	AKT3	100.0	1000
ALK	ALK(L1196M)	97.0	1000
PRKAA1	AMPK-alpha1	100.0	1000
PRKAA2	AMPK-alpha2	100.0	1000
ANKK1	ANKK1	77.0	1000
NUAK1	ARK5	95.0	1000
MAP3K5	ASK1	72.0	1000
MAP3K6	ASK2	65.0	1000
AURKA	AURKA	93.0	1000
AURKB	AURKB	100.0	1000
AURKC	AURKC	90.0	1000
AXL	AXL	92.0	1000
BMP2K	BIKE	88.0	1000
BLK	BLK	77.0	1000
BMPR1A	BMPR1A	100.0	1000
BMPR1B	BMPR1B	71.0	1000
BMPR2	BMPR2	80.0	1000
BMX	BMX	100.0	1000
BRAF	BRAF(V600E)	94.0	1000
PTK6	BRK	100.0	1000
BRSK1	BRSK1	76.0	1000
BRSK2	BRSK2	100.0	1000
BTK	BTK	74.0	1000
BUB1	BUB1	100.0	1000
CAMK1	CAMK1	91.0	1000
PNCK	CAMK1B	71.0	1000
CAMK1D	CAMK1D	82.0	1000
CAMK1G	CAMK1G	100.0	1000
CAMK2A	CAMK2A	100.0	1000
CAMK2B	CAMK2B	100.0	1000
CAMK2D	CAMK2D	75.0	1000
CAMK2G	CAMK2G	98.0	1000
CAMK4	CAMK4	72.0	1000
CAMKK1	CAMKK1	88.0	1000
CAMKK2	CAMKK2	95.0	1000
CASK	CASK	71.0	1000
CDK11B	CDC2L1	100.0	1000
CDK11A	CDC2L2	100.0	1000
CDK13	CDC2L5	90.0	1000
CDK19	CDK11	100.0	1000
CDK2	CDK2	81.0	1000
CDK3	CDK3	100.0	1000
CDK4	CDK4-cyclinD3	81.0	1000
CDK5	CDK5	86.0	1000
CDK7	CDK7	77.0	1000
CDK8	CDK8	78.0	1000
CDK9	CDK9	100.0	1000
CDKL1	CDKL1	75.0	1000
CDKL2	CDKL2	76.0	1000
CDKL3	CDKL3	88.0	1000
CDKL5	CDKL5	100.0	1000
CHEK1	CHEK1	88.0	1000
CHEK2	CHEK2	100.0	1000
CIT	CIT	96.0	1000
CLK1	CLK1	98.0	1000
CLK2	CLK2	95.0	1000
CLK3	CLK3	97.0	1000
CLK4	CLK4	97.0	1000
CSF1R	CSF1R-autoinhibited	91.0	1000
CSK	CSK	100.0	1000
CSNK1A1	CSNK1A1	72.0	1000
CSNK1A1L	CSNK1A1L	89.0	1000
CSNK1D	CSNK1D	74.0	1000
CSNK1E	CSNK1E	98.0	1000
CSNK1G1	CSNK1G1	90.0	1000
CSNK1G2	CSNK1G2	88.0	1000
CSNK1G3	CSNK1G3	100.0	1000
CSNK2A1	CSNK2A1	61.0	1000
CSNK2A2	CSNK2A2	100.0	1000
MATK	CTK	100.0	1000
DAPK1	DAPK1	100.0	1000
DAPK2	DAPK2	79.0	1000
DAPK3	DAPK3	0.0	1000	> 10000.0
DCLK1	DCAMKL1	77.0	1000
DCLK2	DCAMKL2	92.0	1000
DCLK3	DCAMKL3	69.0	1000
DDR1	DDR1	86.0	1000
DDR2	DDR2	100.0	1000
MAP3K12	DLK	100.0	1000
DMPK	DMPK	100.0	1000
CDC42BPG	DMPK2	80.0	1000
STK17A	DRAK1	86.0	1000
STK17B	DRAK2	73.0	1000
DYRK1A	DYRK1A	100.0	1000
DYRK1B	DYRK1B	100.0	1000
DYRK2	DYRK2	99.0	1000
EGFR	EGFR(T790M)	96.0	1000
EIF2AK1	EIF2AK1	79.0	1000
EPHA1	EPHA1	100.0	1000
EPHA2	EPHA2	100.0	1000
EPHA3	EPHA3	100.0	1000
EPHA4	EPHA4	89.0	1000
EPHA5	EPHA5	85.0	1000
EPHA6	EPHA6	79.0	1000
EPHA7	EPHA7	72.0	1000
EPHA8	EPHA8	63.0	1000
EPHB1	EPHB1	90.0	1000
EPHB2	EPHB2	71.0	1000
EPHB3	EPHB3	80.0	1000
EPHB4	EPHB4	100.0	1000
EPHB6	EPHB6	78.0	1000
ERBB2	ERBB2	71.0	1000
ERBB3	ERBB3	88.0	1000
ERBB4	ERBB4	77.0	1000
MAPK3	ERK1	74.0	1000
MAPK1	ERK2	89.0	1000
MAPK6	ERK3	72.0	1000
MAPK4	ERK4	86.0	1000
MAPK7	ERK5	96.0	1000
MAPK15	ERK8	100.0	1000
ERN1	ERN1	100.0	1000
PTK2	FAK	79.0	1000
FER	FER	84.0	1000
FES	FES	94.0	1000
FGFR1	FGFR1	85.0	1000
FGFR2	FGFR2	100.0	1000
FGFR3	FGFR3(G697C)	100.0	1000
FGFR4	FGFR4	89.0	1000
FGR	FGR	100.0	1000
FLT1	FLT1	100.0	1000
FLT3	FLT3-autoinhibited	92.0	1000
FLT4	FLT4	70.0	1000
FRK	FRK	100.0	1000
FYN	FYN	100.0	1000
GAK	GAK	100.0	1000
EIF2AK4	GCN2(Kin.Dom.2,S808G)	42.0	1000
GRK1	GRK1	81.0	1000
GRK2	GRK2	58.0	1000
GRK3	GRK3	42.0	1000	> 10000.0
GRK4	GRK4	100.0	1000
GRK7	GRK7	86.0	1000
GSK3A	GSK3A	73.0	1000
GSK3B	GSK3B	65.0	1000
HASPIN	HASPIN	100.0	1000
HCK	HCK	90.0	1000
HIPK1	HIPK1	75.0	1000
HIPK2	HIPK2	80.0	1000
HIPK3	HIPK3	86.0	1000
HIPK4	HIPK4	70.0	1000
MAP4K1	HPK1	95.0	1000
HUNK	HUNK	80.0	1000
CILK1	ICK	86.0	1000
IGF1R	IGF1R	80.0	1000
CHUK	IKK-alpha	100.0	1000
IKBKB	IKK-beta	100.0	1000
IKBKE	IKK-epsilon	94.0	1000
INSR	INSR	88.0	1000
INSRR	INSRR	75.0	1000
IRAK1	IRAK1	96.0	1000
IRAK3	IRAK3	87.0	1000
IRAK4	IRAK4	100.0	1000
ITK	ITK	77.0	1000
JAK1	JAK1(JH2domain-pseudokinase)	69.0	1000
JAK2	JAK2(JH1domain-catalytic)	84.0	1000
JAK3	JAK3(JH1domain-catalytic)	100.0	1000
MAPK8	JNK1	100.0	1000
MAPK9	JNK2	100.0	1000
MAPK10	JNK3	100.0	1000
KIT	KIT-autoinhibited	88.0	1000
RIPK1	RIPK1	81.0	1000
LATS1	LATS1	98.0	1000
LATS2	LATS2	70.0	1000
LCK	LCK	80.0	1000
LIMK1	LIMK1	78.0	1000
LIMK2	LIMK2	92.0	1000
STK11	LKB1	87.0	1000
STK10	LOK	100.0	1000
LRRK2	LRRK2(G2019S)	81.0	1000
LTK	LTK	89.0	1000
LYN	LYN	80.0	1000
MAP3K13	LZK	100.0	1000
MAK	MAK	92.0	1000
MAP3K1	MAP3K1	55.0	1000
MAP3K15	MAP3K15	85.0	1000
MAP3K2	MAP3K2	82.0	1000
MAP3K3	MAP3K3	93.0	1000
MAP3K4	MAP3K4	100.0	1000
MAP4K2	MAP4K2	83.0	1000
MAP4K3	MAP4K3	100.0	1000
MAP4K4	MAP4K4	100.0	1000
MAP4K5	MAP4K5	100.0	1000
MAPKAPK2	MAPKAPK2	100.0	1000
MAPKAPK5	MAPKAPK5	73.0	1000
MARK1	MARK1	99.0	1000
MARK2	MARK2	92.0	1000
MARK3	MARK3	95.0	1000
MARK4	MARK4	100.0	1000
MAST1	MAST1	91.0	1000
MAP2K1	MEK1	100.0	1000
MAP2K2	MEK2	75.0	1000
MAP2K3	MEK3	81.0	1000
MAP2K4	MEK4	93.0	1000
MAP2K5	MEK5	87.0	1000
MAP2K6	MEK6	100.0	1000
MELK	MELK	81.0	1000
MERTK	MERTK	75.0	1000
MET	MET(Y1235D)	96.0	1000
MINK1	MINK	72.0	1000
MAP2K7	MKK7	87.0	1000
MKNK1	MKNK1	82.0	1000
MKNK2	MKNK2	100.0	1000
MYLK3	MLCK	100.0	1000
MAP3K9	MLK1	88.0	1000
MAP3K10	MLK2	94.0	1000
MAP3K11	MLK3	94.0	1000
CDC42BPA	MRCKA	84.0	1000
CDC42BPB	MRCKB	100.0	1000
STK4	MST1	81.0	1000
MST1R	MST1R	100.0	1000
STK3	MST2	100.0	1000
STK24	MST3	94.0	1000
STK26	MST4	80.0	1000
MTOR	MTOR	100.0	1000
MUSK	MUSK	90.0	1000
MYLK	MYLK	77.0	1000
MYLK2	MYLK2	100.0	1000
MYLK4	MYLK4	90.0	1000
MYO3A	MYO3A	85.0	1000
MYO3B	MYO3B	96.0	1000
STK38	NDR1	76.0	1000
STK38L	NDR2	58.0	1000
NEK1	NEK1	100.0	1000
NEK10	NEK10	100.0	1000
NEK11	NEK11	95.0	1000
NEK2	NEK2	100.0	1000
NEK3	NEK3	80.0	1000
NEK4	NEK4	58.0	1000
NEK5	NEK5	72.0	1000
NEK6	NEK6	84.0	1000
NEK7	NEK7	68.0	1000
NEK9	NEK9	75.0	1000
MAP3K14	NIK	92.0	1000
NIM1K	NIM1	100.0	1000
NLK	NLK	100.0	1000
OXSR1	OSR1	100.0	1000
MAPK14	p38-alpha	81.0	1000
MAPK11	p38-beta	100.0	1000
MAPK13	p38-delta	100.0	1000
MAPK12	p38-gamma	51.0	1000
PAK1	PAK1	96.0	1000
PAK2	PAK2	100.0	1000
PAK3	PAK3	83.0	1000
PAK4	PAK4	84.0	1000
PAK6	PAK6	100.0	1000
PAK5	PAK7	94.0	1000
CDK16	PCTK1	100.0	1000
CDK17	PCTK2	100.0	1000
CDK18	PCTK3	93.0	1000
PDGFRA	PDGFRA	76.0	1000
PDGFRB	PDGFRB	83.0	1000
PDPK1	PDPK1	97.0	1000
CDPK1	PFCDPK1(P.falciparum)	57.0	1000
PK5	PFPK5(P.falciparum)	100.0	1000
CDK15	PFTAIRE2	63.0	1000
CDK14	PFTK1	100.0	1000
PHKG1	PHKG1	76.0	1000
PHKG2	PHKG2	73.0	1000
PIK3C2B	PIK3C2B	86.0	1000
PIK3C2G	PIK3C2G	100.0	1000
PIK3CA	PIK3CA(Q546K)	100.0	1000
PIK3CB	PIK3CB	100.0	1000
PIK3CD	PIK3CD	51.0	1000
PIK3CG	PIK3CG	91.0	1000
PI4KB	PIK4CB	79.0	1000
PIKFYVE	PIKFYVE	100.0	1000
PIM1	PIM1	82.0	1000
PIM2	PIM2	88.0	1000
PIM3	PIM3	100.0	1000
PIP5K1A	PIP5K1A	100.0	1000
PIP5K1C	PIP5K1C	77.0	1000
PIP4K2B	PIP5K2B	100.0	1000
PIP4K2C	PIP5K2C	100.0	1000
PRKACA	PKAC-alpha	81.0	1000
PRKACB	PKAC-beta	97.0	1000
PKMYT1	PKMYT1	100.0	1000
PKN1	PKN1	60.0	1000
PKN2	PKN2	100.0	1000
PKNB	PKNB(M.tuberculosis)	77.0	1000
PLK1	PLK1	100.0	1000
PLK2	PLK2	97.0	1000
PLK3	PLK3	88.0	1000
PLK4	PLK4	76.0	1000
PRKCD	PRKCD	71.0	1000
PRKCE	PRKCE	96.0	1000
PRKCH	PRKCH	100.0	1000
PRKCI	PRKCI	72.0	1000
PRKCQ	PRKCQ	76.0	1000
PRKD1	PRKD1	100.0	1000
PRKD2	PRKD2	96.0	1000
PRKD3	PRKD3	100.0	1000
PRKG1	PRKG1	100.0	1000
PRKG2	PRKG2	90.0	1000
EIF2AK2	PRKR	91.0	1000
PRKX	PRKX	100.0	1000
PRPF4B	PRP4	78.0	1000
PTK2B	PYK2	76.0	1000
SIK3	QSK	70.0	1000
RAF1	RAF1	100.0	1000
RET	RET(V804M)	86.0	1000
RIOK1	RIOK1	80.0	1000
RIOK2	RIOK2	83.0	1000
RIOK3	RIOK3	91.0	1000
RIPK2	RIPK2	100.0	1000
RIPK4	RIPK4	72.0	1000
DSTYK	RIPK5	92.0	1000
ROCK1	ROCK1	82.0	1000
ROCK2	ROCK2	67.0	1000
ROS1	ROS1	95.0	1000
RPS6KA4	RPS6KA4(Kin.Dom.2-C-terminal)	74.0	1000
RPS6KA5	RPS6KA5(Kin.Dom.2-C-terminal)	87.0	1000
RPS6KA1	RSK1(Kin.Dom.2-C-terminal)	100.0	1000
RPS6KA3	RSK2(Kin.Dom.2-C-terminal)	78.0	1000
RPS6KA2	RSK3(Kin.Dom.2-C-terminal)	93.0	1000
RPS6KA6	RSK4(Kin.Dom.2-C-terminal)	81.0	1000
RPS6KB1	S6K1	75.0	1000
SBK1	SBK1	100.0	1000
SGK1	SGK	87.0	1000
SBK3	SgK110	86.0	1000
SGK2	SGK2	72.0	1000
SGK3	SGK3	100.0	1000
SIK1	SIK	88.0	1000
SIK2	SIK2	96.0	1000
SLK	SLK	76.0	1000
NUAK2	SNARK	100.0	1000
SNRK	SNRK	94.0	1000
SRC	SRC	85.0	1000
SRMS	SRMS	84.0	1000
SRPK1	SRPK1	73.0	1000
SRPK2	SRPK2	100.0	1000
SRPK3	SRPK3	100.0	1000
STK16	STK16	83.0	1000
STK33	STK33	93.0	1000
STK35	STK35	99.0	1000
STK36	STK36	79.0	1000
STK39	STK39	89.0	1000
SYK	SYK	75.0	1000
MAP3K7	TAK1	99.0	1000
TAOK1	TAOK1	96.0	1000
TAOK2	TAOK2	71.0	1000
TAOK3	TAOK3	77.0	1000
TBK1	TBK1	87.0	1000
TEC	TEC	75.0	1000
TESK1	TESK1	100.0	1000
TGFBR1	TGFBR1	100.0	1000
TGFBR2	TGFBR2	85.0	1000
TIE1	TIE1	65.0	1000
TEK	TIE2	100.0	1000
TLK1	TLK1	94.0	1000
TLK2	TLK2	96.0	1000
TNIK	TNIK	100.0	1000
TNK1	TNK1	55.0	1000
TNK2	TNK2	100.0	1000
TNNI3K	TNNI3K	87.0	1000
NTRK1	TRKA	100.0	1000
NTRK2	TRKB	87.0	1000
NTRK3	TRKC	81.0	1000
TRPM6	TRPM6	64.0	1000
TSSK1B	TSSK1B	66.0	1000
TSSK3	TSSK3	88.0	1000
TTK	TTK	91.0	1000
TXK	TXK	100.0	1000
TYK2	TYK2(JH2domain-pseudokinase)	86.0	1000
TYRO3	TYRO3	76.0	1000
ULK1	ULK1	100.0	1000
ULK2	ULK2	76.0	1000
ULK3	ULK3	100.0	1000
KDR	VEGFR2	82.0	1000
PIK3C3	VPS34	99.0	1000
VRK2	VRK2	77.0	1000
WEE1	WEE1	100.0	1000
WEE2	WEE2	85.0	1000
WNK1	WNK1	91.0	1000
WNK2	WNK2	100.0	1000
WNK3	WNK3	100.0	1000
WNK4	WNK4	100.0	1000
STK32A	YANK1	78.0	1000
STK32B	YANK2	100.0	1000
STK32C	YANK3	88.0	1000
YES1	YES	100.0	1000
STK25	YSK1	78.0	1000
MAP3K19	YSK4	92.0	1000
MAP3K20	ZAK	100.0	1000
ZAP70	ZAP70	90.0	1000

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Selectivity data for probe BTZO-1 and control BTZO-4

PDSP data

BTZO-1

BTZO-4

DiscoverX KinomeScan data

BTZO-1

BTZO-4