Selectivity data for probe JNJ-42396302 and control JNJ-40573663
Jump to control PDSP data
JNJ-42396302
Compound concentration: 10 µM| Receptor | HGNC target name | Inhibition [%] (Primary experimental value) | Ki [nM] (Secondary experimental value) | pKi |
|---|---|---|---|---|
| 5-HT1E | HTR1E | -16.23 | ||
| 5-HT2C | HTR2C | 68.19 | 2197.87 average (n=2) | 5.70 |
| 5-HT3 | HTR3A | 4.69 | ||
| 5-HT5A | HTR5A | 3.93 | ||
| 5-HT6 | HTR6 | 18.47 | ||
| 5-HT7A | HTR7 | 96.07 | 8744.82 average (n=2) | 5.06 |
| Alpha2A | ADRA2A | -15.23 | ||
| Alpha2B | ADRA2B | 78.20 | > 10000.00 average (n=2) | < 5.00 |
| Alpha2C | ADRA2C | 41.34 | ||
| GABAA/BZP | 33.97 | |||
| D2 | DRD2 | -10.48 | ||
| D4 | DRD4 | -3.39 | ||
| DAT | SLC6A3 | 9.55 | ||
| DOR | OPRD1 | 7.84 | ||
| KOR | OPRK1 | 14.47 | ||
| MOR | OPRM1 | -1.51 | ||
| SERT | SLC6A4 | 0.57 | ||
| Sigma 1 | SIGMAR1 | -2.53 | ||
| 5-HT2A | HTR2A | 45.92 | ||
| 5-HT2B | HTR2B | 52.23 | 2293.19 average (n=2) | 5.65 |
| Alpha1A | ADRA1A | 22.98 | ||
| Alpha1B | ADRA1B | -8.94 | ||
| Alpha1D | ADRA1D | 15.26 | ||
| Beta1 | ADRB1 | 3.43 | ||
| Beta2 | ADRB2 | -1.12 | ||
| Beta3 | ADRB3 | -11.24 | ||
| D1 | DRD1 | 2.41 | ||
| D3 | DRD3 | 24.06 | ||
| D5 | DRD5 | 25.31 | ||
| GABAA | 0.32 | |||
| H1 | HRH1 | 24.56 | ||
| H2 | HRH2 | 12.91 | ||
| H3 | HRH3 | 3.70 | ||
| H4 | HRH4 | -1.08 | ||
| M1 | CHRM1 | 2.83 | ||
| M2 | CHRM2 | 10.43 | ||
| M3 | CHRM3 | 6.41 | ||
| M4 | CHRM4 | 5.21 | ||
| M5 | CHRM5 | -1.98 | ||
| NET | SLC6A2 | 16.00 | ||
| GABA/PBR | 2.18 | |||
| 5-HT1A | HTR1A | 22.87 | ||
| Sigma 2 | TMEM97 | 3.07 | ||
| 5-HT1B | HTR1B | -0.76 | ||
| 5-HT1D | HTR1D | 11.46 |
JNJ-40573663
Compound concentration: 10 µM| Receptor | HGNC target name | Inhibition [%] (Primary experimental value) | Ki [nM] (Secondary experimental value) | pKi |
|---|---|---|---|---|
| 5-HT1E | HTR1E | 5.84 | ||
| 5-HT2C | HTR2C | 5.92 | ||
| 5-HT3 | HTR3A | 9.38 | ||
| 5-HT5A | HTR5A | 18.97 | ||
| 5-HT6 | HTR6 | -7.87 | ||
| 5-HT7A | HTR7 | 20.16 | ||
| Alpha2A | ADRA2A | 34.65 | ||
| Alpha2B | ADRA2B | 31.39 | ||
| Alpha2C | ADRA2C | 16.52 | ||
| GABAA/BZP | 22.16 | |||
| D2 | DRD2 | 1.22 | ||
| D4 | DRD4 | 0.44 | ||
| DAT | SLC6A3 | 85.88 | 4132.38 | 5.38 |
| DOR | OPRD1 | 2.73 | ||
| KOR | OPRK1 | 6.44 | ||
| MOR | OPRM1 | 19.63 | ||
| SERT | SLC6A4 | 3.12 | ||
| Sigma 1 | SIGMAR1 | 43.97 | ||
| 5-HT2A | HTR2A | 13.08 | ||
| 5-HT2B | HTR2B | 17.68 | ||
| Alpha1A | ADRA1A | 22.50 | ||
| Alpha1D | ADRA1D | 10.67 | ||
| Beta1 | ADRB1 | 23.54 | ||
| Beta2 | ADRB2 | 8.86 | ||
| Beta3 | ADRB3 | 2.32 | ||
| D1 | DRD1 | 10.61 | ||
| D3 | DRD3 | -6.13 | ||
| D5 | DRD5 | -30.70 | ||
| GABAA | 59.80 | 1822.22 | 5.74 | |
| H1 | HRH1 | 11.16 | ||
| H2 | HRH2 | -11.02 | ||
| H3 | HRH3 | 7.29 | ||
| H4 | HRH4 | -18.99 | ||
| M1 | CHRM1 | 23.67 | ||
| M3 | CHRM3 | -12.09 | ||
| M4 | CHRM4 | -5.45 | ||
| M5 | CHRM5 | -14.50 | ||
| NET | SLC6A2 | 17.37 | ||
| GABA/PBR | -22.81 | |||
| 5-HT1A | HTR1A | 25.73 | ||
| M2 | CHRM2 | 9.44 | ||
| Sigma 2 | TMEM97 | 31.57 | ||
| 5-HT1B | HTR1B | 8.68 | ||
| 5-HT1D | HTR1D | 1.09 | ||
| Alpha1B | ADRA1B | 0.45 |
JNJ-42396302
The panel was screened at 10 µM JNJ-42396302.
Conclusion: Clean panel.
| Target protein | HGNC name | Species | Cmp. conc. | % Effect | Assay ID |
|---|---|---|---|---|---|
| cML1 | MTNR1A | Cricetinae | 10 µM | -4.5 | Old_Cerep_1538 |
| h5HT2A | HTR2A | Homo sapiens | 10 µM | 4.1 | Cerep_471 |
| hAT1 | AGTR1 | Homo sapiens | 10 µM | 14.5 | Cerep_24 |
| hBCXCR2 | CXCR2 | Homo sapiens | 10 µM | 5.2 | Cerep_419 |
| hCB1 | CNR1 | Homo sapiens | 10 µM | 4.1 | Cerep_4708 |
| hCCR1 | CCR1 | Homo sapiens | 10 µM | -7.5 | Cerep_361 |
| hD2S | DRD2 | Homo sapiens | 10 µM | 1.7 | Cerep_46 |
| hGAL2 | GALR2 | Homo sapiens | 10 µM | 6.7 | Cerep_410 |
| hMC4 | MC4R | Homo sapiens | 10 µM | 6.4 | Cerep_420 |
| hNPY1 | NPY1R | Homo sapiens | 10 µM | 0.2 | Cerep_106 |
| hNPY2 | NPY2R | Homo sapiens | 10 µM | 4.5 | Cerep_107 |
| hORL1 | OPRL1 | Homo sapiens | 10 µM | 2.2 | Cerep_358 |
| hVPAC1 | VIPR1 | Homo sapiens | 10 µM | 2.1 | Cerep_157 |
| r5HT1B | HTR1B | Rattus norvegicus | 10 µM | -2.6 | Cerep_132 |
| rCa channel | Rattus norvegicus | 10 µM | 4.8 | Cerep_163 | |
| rNa channel | Rattus norvegicus | 10 µM | -5.6 | Old_Cerep_169 | |
| rOP2 | OPRK1 | Homo sapiens | 10 µM | 1.7 | Cerep_4461 |
| hA1 | ADORA1 | Homo sapiens | 10 µM | 11.4 | Cerep_2 |
| hA2A | ADORA2A | Homo sapiens | 10 µM | 17.8 | Cerep_4 |
| hA3 | ADORA3 | Homo sapiens | 10 µM | 8.4 | Cerep_6 |
| rAa1 |
ADRA1A ADRA1B ADRA1D |
Rattus norvegicus | 10 µM | -2.6 | Cerep_8 |
| rAa2 |
ADRA2A ADRA2B ADRA2C |
Rattus norvegicus | 10 µM | 5.2 | Cerep_11 |
| hAb1 | ADRB1 | Homo sapiens | 10 µM | 6.6 | Cerep_18 |
| hAb2 | ADRB2 | Homo sapiens | 10 µM | -4.5 | Cerep_20 |
| rBZD | Rattus norvegicus | 10 µM | 41.6 | Cerep_28 | |
| hBK2 | BDKRB2 | Homo sapiens | 10 µM | 7.1 | Cerep_33 |
| hCB2 | CNR2 | Homo sapiens | 10 µM | 6.1 | Cerep_37 |
| hCCKA | CCKAR | Homo sapiens | 10 µM | -19.7 | Cerep_39 |
| hCCK2 | CCKBR | Homo sapiens | 10 µM | -5.6 | Cerep_41 |
| hD1 | DRD1 | Homo sapiens | 10 µM | 6.2 | Cerep_44 |
| hDAT | SLC6A3 | Homo sapiens | 10 µM | 4.5 | Cerep_52 |
| hETA | EDNRA | Homo sapiens | 10 µM | 5.6 | Cerep_54 |
| rGABA | Rattus norvegicus | 10 µM | 21.1 | Cerep_57 | |
| rSLC6/GABA | Rattus norvegicus | 10 µM | -6.0 | Cerep_60 | |
| rGlutamate (ionotropic) AMPA | Rattus norvegicus | 10 µM | 7.7 | Cerep_64 | |
| rGlutamate (ionotropic) kanic acid | Rattus norvegicus | 10 µM | -25.3 | Cerep_65 | |
| rNMDA | Rattus norvegicus | 10 µM | -9.5 | Cerep_66 | |
| glyine | Rattus norvegicus | 10 µM | -23.1 | Old_Cerep_70 | |
| rGlutamate (ionotropic) MDL | Rattus norvegicus | 10 µM | -6.2 | Old_Cerep_68 | |
| hM1 | CHRM1 | Homo sapiens | 10 µM | 2.2 | Cerep_91 |
| hM2 | CHRM2 | Homo sapiens | 10 µM | 11.0 | Cerep_93 |
| hM3 | CHRM3 | Homo sapiens | 10 µM | 13.9 | Cerep_95 |
| hM4 | CHRM4 | Homo sapiens | 10 µM | -3.1 | Cerep_96 |
| hM5 | CHRM5 | Homo sapiens | 10 µM | -0.6 | Cerep_97 |
| hNK1 | TACR1 | Homo sapiens | 10 µM | 3.1 | Cerep_100 |
| hNK2 | TACR2 | Homo sapiens | 10 µM | 9.7 | Cerep_102 |
| hNK3 | TACR3 | Homo sapiens | 10 µM | -8.7 | Cerep_104 |
| hNT1 | NTSR1 | Homo sapiens | 10 µM | 12.3 | Cerep_109 |
| hOP1 | OPRD1 | Homo sapiens | 10 µM | 9.0 | Cerep_114 |
| hOP3 | OPRM1 | Homo sapiens | 10 µM | 2.2 | Cerep_118 |
| rPCP | Rattus norvegicus | 10 µM | -3.5 | Cerep_124 | |
| rP2X | Rattus norvegicus | 10 µM | 7.0 | Old_Cerep_127 | |
| h5HT1A | HTR1A | Homo sapiens | 10 µM | 8.7 | Cerep_131 |
| h5HT2C | HTR2C | Homo sapiens | 10 µM | -2.0 | Cerep_137 |
| h5HT5A | HTR5A | Homo sapiens | 10 µM | 5.7 | Cerep_140 |
| h5HT6 | HTR6 | Homo sapiens | 10 µM | 4.9 | Cerep_142 |
| h5HT7 | HTR7 | Homo sapiens | 10 µM | 8.6 | Cerep_144 |
| mSST | Mus musculus | 10 µM | 2.8 | Cerep_149 | |
| hV1a | AVPR1A | Homo sapiens | 10 µM | 8.9 | Cerep_159 |
| rK_ATP potassium channel | Rattus norvegicus | 10 µM | 2.9 | Old_Cerep_165 | |
| rK channel | Rattus norvegicus | 10 µM | -9.5 | Cerep_166 | |
| rSKCa channel | Rattus norvegicus | 10 µM | 7.4 | Cerep_167 | |
| rCL channel | Rattus norvegicus | 10 µM | -12.3 | Old_Cerep_170 | |
| hMAOA | MAOA | Homo sapiens | 10 µM | 13.8 | Old_Cerep_191 |
| hNET | SLC6A2 | Homo sapiens | 10 µM | 6.7 | Cerep_355 |
| hACHE | ACHE | Homo sapiens | 10 µM | 0.2 | Cerep_363 |
| h5HT3 | HTR3A | Homo sapiens | 10 µM | 3.4 | Cerep_411 |
| hEP4 | PTGER4 | Homo sapiens | 10 µM | 13.6 | Cerep_441 |
| hGR | NR3C1 | Homo sapiens | 10 µM | 1.9 | Cerep_469 |
| PPAR1C | PPARG | Homo sapiens | 10 µM | -2.1 | Cerep_641 |
| hH1 | HRH1 | Homo sapiens | 10 µM | 2.1 | Cerep_870 |
| hAR | AR | Homo sapiens | 10 µM | -13.9 | Cerep_933 |
| hN muscle type alpha | Homo sapiens | 10 µM | -7.3 | Cerep_936 | |
| hH2 | HRH2 | Homo sapiens | 10 µM | 18.1 | Cerep_1208 |
| h5HT2B | HTR2B | Homo sapiens | 10 µM | 2.4 | Cerep_1333 |
| hEP2 | PTGER2 | Homo sapiens | 10 µM | 4.0 | Cerep_1955 |
| hIP1 | PTGIR | Homo sapiens | 10 µM | -23.4 | Cerep_2230 |
| hPR | PGR | Homo sapiens | 10 µM | 13.5 | Cerep_2341 |
| hLck | LCK | Homo sapiens | 10 µM | -2.4 | Old_Cerep_2906 |
| hNneuronala4b2 |
CHRNA4 CHRNB2 |
Homo sapiens | 10 µM | -3.0 | Cerep_3029 |
| hSigma | Homo sapiens | 10 µM | 1.6 | Cerep_3500 | |
| hTSPO | TSPO | Homo sapiens | 10 µM | 2.8 | Cerep_3643 |
| hPDE3A | PDE3A | Homo sapiens | 10 µM | 6.0 | Cerep_4072 |
| hPDE4D2 | PDE4D | Homo sapiens | 10 µM | 27.3 | Cerep_4077 |
| hCOX1 | PTGS1 | Homo sapiens | 10 µM | 13.0 | Cerep_4173 |
| hCOX2 | PTGS2 | Homo sapiens | 10 µM | 13.4 | Cerep_4186 |
JNJ-42396302
JNJ-42396302 was screened versus other PDE family members.
Conclusion: PDE selectivity > 250 fold: closest hit is PDE1B with Ki = 3.4 µM (257 fold)
| Target protein | HGNC name | Species | Ki [µM] |
|---|---|---|---|
| hPDE1B1 | PDE1B | Homo sapiens | 3.4 |
| hPDE2A | PDE2A | Homo sapiens | 32.0 |
| hPDE3A | PDE3A | Homo sapiens | 49.0 |
| hPDE4D3 | PDE4D | Homo sapiens | 15.0 |
| hPDE5A3 | PDE5A | Homo sapiens | 8.5 |
| hPDE6AB | PDE6A | Homo sapiens | 85.0 |
| hPDE7A1 | PDE7A | Homo sapiens | 23.0 |
| hPDE8A1 | PDE8A | Homo sapiens | 41.0 |
| hPDE9A | PDE9A | Homo sapiens | > 33.0 |
| hPDE10A2 | PDE10A | Homo sapiens | 0.0 |
| hPDE11A4 | PDE11A | Homo sapiens | 46.0 |
JNJ-42396302
The radiometric assay was performed in the presence of 10 µM ATP.
Conclusion: Clean panel.
| Target protein | HGNC name | Species | % inhibition at 10 µM |
|---|---|---|---|
| CHK1 checkpoint homolog (S. pombe) | CHEK1 | Homo sapiens | -9.0 |
| colony stimulating factor 1 receptor | CSF1R | Homo sapiens | 4.0 |
| conserved helix-loop-helix ubiquitous kinase | CHUK | Homo sapiens | -3.0 |
| cyclin-dependent kinase 1 / clyclinB | CDK1 | Homo sapiens | 5.0 |
| cyclin-dependent kinase 2 / clyclinA | CDK2 | Homo sapiens | 2.0 |
| cyclin-dependent kinase 2 /clyclinE | CDK2 | Homo sapiens | 1.0 |
| cyclin-dependent kinase 3 / cyclinE | CDK3 | Homo sapiens | 7.0 |
| cyclin-dependent kinase 5 / p25 | CDK5 | Homo sapiens | 0.0 |
| cyclin-dependent kinase 5 / p35 | CDK5 | Homo sapiens | -5.0 |
| cyclin-dependent kinase 6 / cyclinD3 | CDK6 | Homo sapiens | 0.0 |
| Cyclin-dependent kinase 7 / cyclinH / MAT | CDK7 | Homo sapiens | 1.0 |
| cyclin-dependent kinase 9 / cyclinT1 | CDK9 | Homo sapiens | -1.0 |
| death-associated protein kinase 1 | DAPK1 | Homo sapiens | -2.0 |
| death-associated protein kinase 2 | DAPK2 | Homo sapiens | -1.0 |
| death-associated protein kinase 3 | DAPK3 | Homo sapiens | -2.0 |
| discoidin domain receptor tyrosine kinase 2 | DDR2 | Homo sapiens | -5.0 |
| doublecortin-like kinase 2 | DCLK2 | Homo sapiens | -6.0 |
| dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 | DYRK1A | Homo sapiens | -3.0 |
| dystrophia myotonica-protein kinase | DMPK | Homo sapiens | -15.0 |
| EPH receptor A1 | EPHA1 | Homo sapiens | 7.0 |
| EPH receptor A2 | EPHA2 | Homo sapiens | 7.0 |
| EPH receptor A3 | EPHA3 | Homo sapiens | 4.0 |
| EPH receptor A4 | EPHA4 | Homo sapiens | 2.0 |
| EPH receptor A5 | EPHA5 | Homo sapiens | -9.0 |
| EPH receptor A7 | EPHA7 | Homo sapiens | 0.0 |
| EPH receptor A8 | EPHA8 | Homo sapiens | 0.0 |
| EPH receptor B1 | EPHB1 | Homo sapiens | 2.0 |
| EPH receptor B2 | EPHB2 | Homo sapiens | -18.0 |
| EPH receptor B3 | EPHB3 | Homo sapiens | 3.0 |
| EPH receptor B4 | EPHB4 | Homo sapiens | -35.0 |
| epidermal growth factor receptor | EGFR | Homo sapiens | -19.0 |
| eukaryotic elongation factor-2 kinase | EEF2K | Homo sapiens | -2.0 |
| feline sarcoma oncogene | FES | Homo sapiens | 13.0 |
| fer (fps/fes related) tyrosine kinase | FER | Homo sapiens | 0.0 |
| fibroblast growth factor receptor 1 | FGFR1 | Homo sapiens | 8.0 |
| fibroblast growth factor receptor 2 | FGFR2 | Homo sapiens | -5.0 |
| fibroblast growth factor receptor 3 | FGFR3 | Homo sapiens | -2.0 |
| fibroblast growth factor receptor 4 | FGFR4 | Homo sapiens | -7.0 |
| fms-related tyrosine kinase 1 | FLT1 | Homo sapiens | -5.0 |
| fms-related tyrosine kinase 3 | FLT3 | Homo sapiens | 6.0 |
| fms-related tyrosine kinase 4 | FLT4 | Homo sapiens | -4.0 |
| fyn-related kinase | FRK | Homo sapiens | -7.0 |
| FYN oncogene related to SRC, FGR, YES | FYN | Homo sapiens | 3.0 |
| G protein-coupled receptor kinase 5 | GRK5 | Homo sapiens | -4.0 |
| G protein-coupled receptor kinase 6 | GRK6 | Homo sapiens | 3.0 |
| G protein-coupled receptor kinase 7 | GRK7 | Homo sapiens | 6.0 |
| Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog | FGR | Homo sapiens | 7.0 |
| germ cell associated 2 (haspin) | HASPIN | Homo sapiens | 5.0 |
| glycogen synthase kinase 3 alpha | GSK3A | Homo sapiens | -42.0 |
| glycogen synthase kinase 3 beta | GSK3B | Homo sapiens | -1.0 |
| hemopoietic cell kinase (activated) | HCK | Homo sapiens | -3.0 |
| hemopoietic cell kinase | HCK | Homo sapiens | -2.0 |
| homeodomain interacting protein kinase 1 | HIPK1 | Homo sapiens | 11.0 |
| homeodomain interacting protein kinase 2 | HIPK2 | Homo sapiens | 0.0 |
| homeodomain interacting protein kinase 3 | HIPK3 | Homo sapiens | -6.0 |
| IL2-inducible T-cell kinase | ITK | Homo sapiens | 1.0 |
| inhib of kappa light polypeptide gene enhancer in B-cells, kinase beta | IKBKB | Homo sapiens | -16.0 |
| insulin-like growth factor 1 receptor (activated) | IGF1R | Homo sapiens | 3.0 |
| insulin-like growth factor 1 receptor | IGF1R | Homo sapiens | 1.0 |
| insulin receptor-related receptor | INSRR | Homo sapiens | 10.0 |
| insulin receptor (activated) | INSR | Homo sapiens | -2.0 |
| insulin receptor | INSR | Homo sapiens | -16.0 |
| interleukin-1 receptor-associated kinase 1 | IRAK1 | Homo sapiens | -3.0 |
| interleukin-1 receptor-associated kinase 4 | IRAK4 | Homo sapiens | -1.0 |
| Janus kinase 2 | JAK2 | Homo sapiens | -32.0 |
| Janus kinase 3 | JAK3 | Homo sapiens | -13.0 |
| kinase insert domain receptor | KDR | Homo sapiens | -4.0 |
| LIM domain kinase 1 | LIMK1 | Homo sapiens | -3.0 |
| lymphocyte-specific protein tyrosine kinase (activated) | LCK | Homo sapiens | -4.0 |
| lymphocyte-specific protein tyrosine kinase | LCK | Homo sapiens | 13.0 |
| macrophage stimulating 1 receptor | MST1R | Homo sapiens | 3.0 |
| MAP kinase interacting serine/threonine kinase 2 | MKNK2 | Homo sapiens | 10.0 |
| MAP/microtubule affinity-regulating kinase 1 | MARK1 | Homo sapiens | -6.0 |
| MAP/microtubule affinity-regulating kinase 2 | MARK2 | Homo sapiens | 9.0 |
| mechanistic target of rapamycin / FKBP12 | MTOR | Homo sapiens | 9.0 |
| mechanistic target of rapamycin | MTOR | Homo sapiens | 1.0 |
| met proto-oncogene | MET | Homo sapiens | -6.0 |
| misshapen-like kinase 1 | MINK1 | Homo sapiens | 9.0 |
| mitogen-activated protein kinase-activated protein kinase 2 | MAPKAPK2 | Homo sapiens | -5.0 |
| mitogen-activated protein kinase-activated protein kinase 3 | MAPKAPK3 | Homo sapiens | 3.0 |
| mitogen-activated protein kinase-activated protein kinase 5 | MAPKAPK5 | Homo sapiens | 7.0 |
| mitogen-activated protein kinase 1 (MAPK2) | MAPK1 | Homo sapiens | 4.0 |
| mitogen-activated protein kinase 1 | MAPK1 | Homo sapiens | 1.0 |
| mitogen-activated protein kinase 10 | MAPK10 | Homo sapiens | 18.0 |
| mitogen-activated protein kinase 11 | MAPK11 | Homo sapiens | -2.0 |
| mitogen-activated protein kinase 12 | MAPK12 | Homo sapiens | 2.0 |
| mitogen-activated protein kinase 13 | MAPK13 | Homo sapiens | 4.0 |
| mitogen-activated protein kinase 14 | MAPK14 | Homo sapiens | -4.0 |
| mitogen-activated protein kinase 8 | MAPK8 | Homo sapiens | -3.0 |
| mitogen-activated protein kinase 9 | MAPK9 | Homo sapiens | 0.0 |
| mitogen-activated protein kinase kinase 1 | MAP2K1 | Homo sapiens | -1.0 |
| mitogen-activated protein kinase kinase 6 | MAP2K6 | Homo sapiens | -5.0 |
| mitogen-activated protein kinase kinase 7 | MAP2K7 | Homo sapiens | -11.0 |
| mitogen-activated protein kinase kinase kinase 5 | MAP3K5 | Homo sapiens | -2.0 |
| mitogen-activated protein kinase kinase kinase 7 | MAP3K7 | Homo sapiens | 5.0 |
| mitogen-activated protein kinase kinase kinase 9 | MAP3K9 | Homo sapiens | 5.0 |
| mitogen-activated protein kinase kinase kinase kinase 1 | MAP4K1 | Homo sapiens | 5.5 |
| mitogen-activated protein kinase kinase kinase kinase 2 | MAP4K2 | Homo sapiens | -5.0 |
| muscle, skeletal, receptor tyrosine kinase | MUSK | Homo sapiens | -6.0 |
| myosin light chain kinase | MYLK | Homo sapiens | 2.0 |
| nemo-like kinase | NLK | Homo sapiens | 2.0 |
| neurotrophic tyrosine kinase, receptor, type 1 | NTRK1 | Homo sapiens | 7.0 |
| neurotrophic tyrosine kinase, receptor, type 2 | NTRK2 | Homo sapiens | -5.0 |
| NIMA -related kinase 11 | NEK11 | Homo sapiens | -2.0 |
| NIMA -related kinase 2 | NEK2 | Homo sapiens | -1.0 |
| NIMA -related kinase 3 | NEK3 | Homo sapiens | 4.0 |
| NIMA -related kinase 6 | NEK6 | Homo sapiens | 1.0 |
| NIMA -related kinase 7 | NEK7 | Homo sapiens | 2.0 |
| NUAK family, SNF1-like kinase, 1 | NUAK1 | Homo sapiens | 7.0 |
| p21 protein -activated kinase 2 | PAK2 | Homo sapiens | -3.0 |
| p21 protein -activated kinase 3 | PAK3 | Homo sapiens | -13.0 |
| p21 protein -activated kinase 4 | PAK4 | Homo sapiens | -11.0 |
| p21 protein -activated kinase 5 | PAK5 | Homo sapiens | 7.0 |
| p21 protein -activated kinase 6 | PAK6 | Homo sapiens | 5.0 |
| PAS domain containing serine/threonine kinase | PASK | Homo sapiens | 5.0 |
| phosphoinositide-3-kinase, catalytic, beta polypeptide | PIK3CB | Homo sapiens | 1.0 |
| phosphoinositide-3-kinase, catalytic, delta polypeptide | PIK3CD | Homo sapiens | 1.0 |
| phosphoinositide-3-kinase, catalytic, gamma polypeptide | PIK3CG | Homo sapiens | -4.0 |
| phosphorylase kinase, gamma 2 | PHKG2 | Homo sapiens | -3.0 |
| pim-1 oncogene | PIM1 | Homo sapiens | 10.0 |
| pim-2 oncogene | PIM2 | Homo sapiens | -44.0 |
| pim-3 oncogene | PIM3 | Homo sapiens | 11.0 |
| platelet-derived growth factor receptor, alpha polypeptide | PDGFA | Homo sapiens | -18.0 |
| platelet-derived growth factor receptor, beta polypeptide | PDGFB | Homo sapiens | -3.0 |
| polo-like kinase 1 | PLK1 | Homo sapiens | 0.0 |
| polo-like kinase 2 | PLK2 | Homo sapiens | -7.0 |
| polo-like kinase 3 | PLK3 | Homo sapiens | -2.0 |
| protein kinase C, alpha | PRKCA | Homo sapiens | 15.0 |
| protein kinase C, beta 1 | PRKCB | Homo sapiens | -5.0 |
| protein kinase C, beta 2 | PRKCB | Homo sapiens | 3.0 |
| protein kinase C, delta | PRKCD | Homo sapiens | -2.0 |
| protein kinase C, epsilon | PRKCE | Homo sapiens | -11.0 |
| protein kinase C, eta | PRKCH | Homo sapiens | -2.0 |
| protein kinase C, gamma | PRKCG | Homo sapiens | -4.0 |
| protein kinase C, iota | PRKCI | Homo sapiens | 3.0 |
| protein kinase C, theta | PRKCQ | Homo sapiens | 2.0 |
| protein kinase C, zeta | PRKCZ | Homo sapiens | 5.0 |
| protein kinase D1 | PRKD1 | Homo sapiens | -5.0 |
| protein kinase D2 | PRKD2 | Homo sapiens | 2.0 |
| protein kinase N2 | PKN2 | Homo sapiens | -22.0 |
| protein kinase, AMP-activated, alpha 1 catalytic subunit | PRKAA1 | Homo sapiens | -11.0 |
| protein kinase, AMP-activated, alpha 2 catalytic subunit | PRKAA2 | Homo sapiens | 2.0 |
| protein kinase, cAMP-dependent, catalytic, alpha | PRKACA | Homo sapiens | -37.0 |
| protein kinase, cGMP-dependent, type I | PRKG1 | Homo sapiens | 2.0 |
| protein kinase, cGMP-dependent, type II | PRKG2 | Homo sapiens | 1.0 |
| protein kinase, X-linked | PRKX | Homo sapiens | 4.0 |
| PTK2 protein tyrosine kinase 2 | PTK2 | Homo sapiens | -2.0 |
| PTK2B protein tyrosine kinase 2 beta | PTK2B | Homo sapiens | -4.0 |
| PTK6 protein tyrosine kinase 6 | PTK6 | Homo sapiens | -6.0 |
| receptor-interacting serine-threonine kinase 2 | RIPK2 | Homo sapiens | -6.0 |
| ret proto-oncogene | RET | Homo sapiens | 5.0 |
| Rho-associated, coiled-coil containing protein kinase 1 | ROCK1 | Homo sapiens | -6.0 |
| Rho-associated, coiled-coil containing protein kinase 2 | ROCK2 | Homo sapiens | -3.0 |
| ribosomal protein S6 kinase, 70kDa, polypeptide 1 | RPS6KB1 | Homo sapiens | -7.0 |
| ribosomal protein S6 kinase, 90kDa, polypeptide 1 | RPS6KA1 | Homo sapiens | 9.0 |
| ribosomal protein S6 kinase, 90kDa, polypeptide 2 | RPS6KA2 | Homo sapiens | -16.0 |
| ribosomal protein S6 kinase, 90kDa, polypeptide 3 | RPS6KA3 | Homo sapiens | -20.0 |
| ribosomal protein S6 kinase, 90kDa, polypeptide 4 | RPS6KA4 | Homo sapiens | 2.0 |
| ribosomal protein S6 kinase, 90kDa, polypeptide 5 | RPS6KA5 | Homo sapiens | 3.0 |
| ribosomal protein S6 kinase, 90kDa, polypeptide 6 | RPS6KA6 | Homo sapiens | -10.0 |
| serine/threonine kinase 10 | STK10 | Homo sapiens | 0.0 |
| serine/threonine kinase 11 | STK11 | Homo sapiens | 4.0 |
| serine/threonine kinase 17a | STK17A | Homo sapiens | -9.0 |
| serine/threonine kinase 24 | STK24 | Homo sapiens | 9.0 |
| serine/threonine kinase 3 | STK3 | Homo sapiens | -8.0 |
| serine/threonine kinase 33 | STK33 | Homo sapiens | -1.0 |
| serine/threonine kinase 4 | STK4 | Homo sapiens | -7.0 |
| serum/glucocorticoid regulated kinase 1 | SGK1 | Homo sapiens | -3.0 |
| serum/glucocorticoid regulated kinase 2 | SGK2 | Homo sapiens | -3.0 |
| serum/glucocorticoid regulated kinase family, member 3 | SGK3 | Homo sapiens | 1.0 |
| SFRS protein kinase 1 | SRPK1 | Homo sapiens | -11.0 |
| SFRS protein kinase 2 | SRPK2 | Homo sapiens | -16.0 |
| SFRS protein kinase 3 | SRPK3 | Homo sapiens | -6.0 |
| spleen tyrosine kinase | SYK | Homo sapiens | -7.0 |
| TANK-binding kinase 1 | TBK1 | Homo sapiens | -3.0 |
| TAO kinase 1 | TAOK1 | Homo sapiens | -11.0 |
| TAO kinase 2 | TAOK2 | Homo sapiens | 10.0 |
| TAO kinase 3 | TAOK3 | Homo sapiens | 0.0 |
| tec protein tyrosine kinase (activated) | TEC | Homo sapiens | 7.0 |
| TEK tyrosine kinase, endothelial | TEK | Homo sapiens | 1.0 |
| testis-specific serine kinase 1B | TSSK1B | Homo sapiens | 2.0 |
| testis-specific serine kinase 2 | TSSK2 | Homo sapiens | 1.0 |
| Toll like receptor 4 | TLR4 | Homo sapiens | -5.2 |
| tousled-like kinase 2 | TLR2 | Homo sapiens | -5.0 |
| TXK tyrosine kinase | TXK | Homo sapiens | 6.0 |
| TYRO3 protein tyrosine kinase | TYRO3 | Homo sapiens | 1.0 |
| tyrosine kinase, non-receptor, 2 | TNK2 | Homo sapiens | 0.0 |
| unc-51-like kinase 2 | ULK2 | Homo sapiens | 6.0 |
| unc-51-like kinase 3 | ULK3 | Homo sapiens | -17.0 |
| v-abl Abelson murine leukemia viral oncogene homolog 2 | ABL2 | Homo sapiens | 6.0 |
| v-akt murine thymoma viral oncogene homolog 1 | AKT1 | Homo sapiens | 35.0 |
| v-akt murine thymoma viral oncogene homolog 2 | AKT2 | Homo sapiens | -15.0 |
| v-akt murine thymoma viral oncogene homolog 3 | AKT3 | Homo sapiens | 24.0 |
| v-erb-a erythroblastic leukemia viral oncogene homolog 4 | ERBB4 | Homo sapiens | 9.0 |
| v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog | KIT | Homo sapiens | 4.0 |
| v-raf-1 murine leukemia viral oncogene homolog 1 | RAF | Homo sapiens | 10.0 |
| v-src sarcoma viral oncogene homolog | SRC | Homo sapiens | -5.0 |
| v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1 | YES1 | Homo sapiens | 0.0 |
| v-yes-1 Yamaguchi sarcoma viral related oncogene homolog | LYN | Homo sapiens | -1.0 |
| vaccinia related kinase 2 | VRK2 | Homo sapiens | -4.0 |
| WNK lysine deficient protein kinase 2 | WNK2 | Homo sapiens | -1.0 |
| WNK lysine deficient protein kinase 3 | WNK3 | Homo sapiens | 0.0 |
| zeta-chain associated protein kinase 70kDa | ZAP70 | Homo sapiens | 4.0 |