Selectivity data for probe JNJ-42396302 and control JNJ-40573663


Jump to control PDSP data

JNJ-42396302


Compound concentration: 10 µM
Receptor HGNC target name Inhibition [%] (Primary experimental value) Ki [nM] (Secondary experimental value) pKi
5-HT1E HTR1E -16.23
5-HT2C HTR2C 68.19 2197.87 average (n=2) 5.70
5-HT3 HTR3A 4.69
5-HT5A HTR5A 3.93
5-HT6 HTR6 18.47
5-HT7A HTR7 96.07 8744.82 average (n=2) 5.06
Alpha2A ADRA2A -15.23
Alpha2B ADRA2B 78.20 > 10000.00 average (n=2) < 5.00
Alpha2C ADRA2C 41.34
GABAA/BZP 33.97
D2 DRD2 -10.48
D4 DRD4 -3.39
DAT SLC6A3 9.55
DOR OPRD1 7.84
KOR OPRK1 14.47
MOR OPRM1 -1.51
SERT SLC6A4 0.57
Sigma 1 SIGMAR1 -2.53
5-HT2A HTR2A 45.92
5-HT2B HTR2B 52.23 2293.19 average (n=2) 5.65
Alpha1A ADRA1A 22.98
Alpha1B ADRA1B -8.94
Alpha1D ADRA1D 15.26
Beta1 ADRB1 3.43
Beta2 ADRB2 -1.12
Beta3 ADRB3 -11.24
D1 DRD1 2.41
D3 DRD3 24.06
D5 DRD5 25.31
GABAA 0.32
H1 HRH1 24.56
H2 HRH2 12.91
H3 HRH3 3.70
H4 HRH4 -1.08
M1 CHRM1 2.83
M2 CHRM2 10.43
M3 CHRM3 6.41
M4 CHRM4 5.21
M5 CHRM5 -1.98
NET SLC6A2 16.00
GABA/PBR 2.18
5-HT1A HTR1A 22.87
Sigma 2 TMEM97 3.07
5-HT1B HTR1B -0.76
5-HT1D HTR1D 11.46

JNJ-40573663


Compound concentration: 10 µM
Receptor HGNC target name Inhibition [%] (Primary experimental value) Ki [nM] (Secondary experimental value) pKi
5-HT1E HTR1E 5.84
5-HT2C HTR2C 5.92
5-HT3 HTR3A 9.38
5-HT5A HTR5A 18.97
5-HT6 HTR6 -7.87
5-HT7A HTR7 20.16
Alpha2A ADRA2A 34.65
Alpha2B ADRA2B 31.39
Alpha2C ADRA2C 16.52
GABAA/BZP 22.16
D2 DRD2 1.22
D4 DRD4 0.44
DAT SLC6A3 85.88 4132.38 5.38
DOR OPRD1 2.73
KOR OPRK1 6.44
MOR OPRM1 19.63
SERT SLC6A4 3.12
Sigma 1 SIGMAR1 43.97
5-HT2A HTR2A 13.08
5-HT2B HTR2B 17.68
Alpha1A ADRA1A 22.50
Alpha1D ADRA1D 10.67
Beta1 ADRB1 23.54
Beta2 ADRB2 8.86
Beta3 ADRB3 2.32
D1 DRD1 10.61
D3 DRD3 -6.13
D5 DRD5 -30.70
GABAA 59.80 1822.22 5.74
H1 HRH1 11.16
H2 HRH2 -11.02
H3 HRH3 7.29
H4 HRH4 -18.99
M1 CHRM1 23.67
M3 CHRM3 -12.09
M4 CHRM4 -5.45
M5 CHRM5 -14.50
NET SLC6A2 17.37
GABA/PBR -22.81
5-HT1A HTR1A 25.73
M2 CHRM2 9.44
Sigma 2 TMEM97 31.57
5-HT1B HTR1B 8.68
5-HT1D HTR1D 1.09
Alpha1B ADRA1B 0.45

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JNJ-42396302

The panel was screened at 10 µM JNJ-42396302.

Conclusion: Clean panel.

Target protein HGNC name Species Cmp. conc. % Effect Assay ID
cML1 MTNR1A Cricetinae 10 µM -4.5 Old_Cerep_1538
h5HT2A HTR2A Homo sapiens 10 µM 4.1 Cerep_471
hAT1 AGTR1 Homo sapiens 10 µM 14.5 Cerep_24
hBCXCR2 CXCR2 Homo sapiens 10 µM 5.2 Cerep_419
hCB1 CNR1 Homo sapiens 10 µM 4.1 Cerep_4708
hCCR1 CCR1 Homo sapiens 10 µM -7.5 Cerep_361
hD2S DRD2 Homo sapiens 10 µM 1.7 Cerep_46
hGAL2 GALR2 Homo sapiens 10 µM 6.7 Cerep_410
hMC4 MC4R Homo sapiens 10 µM 6.4 Cerep_420
hNPY1 NPY1R Homo sapiens 10 µM 0.2 Cerep_106
hNPY2 NPY2R Homo sapiens 10 µM 4.5 Cerep_107
hORL1 OPRL1 Homo sapiens 10 µM 2.2 Cerep_358
hVPAC1 VIPR1 Homo sapiens 10 µM 2.1 Cerep_157
r5HT1B HTR1B Rattus norvegicus 10 µM -2.6 Cerep_132
rCa channel Rattus norvegicus 10 µM 4.8 Cerep_163
rNa channel Rattus norvegicus 10 µM -5.6 Old_Cerep_169
rOP2 OPRK1 Homo sapiens 10 µM 1.7 Cerep_4461
hA1 ADORA1 Homo sapiens 10 µM 11.4 Cerep_2
hA2A ADORA2A Homo sapiens 10 µM 17.8 Cerep_4
hA3 ADORA3 Homo sapiens 10 µM 8.4 Cerep_6
rAa1 ADRA1A
 ADRA1B
 ADRA1D
 		Rattus norvegicus 10 µM -2.6 Cerep_8
rAa2 ADRA2A
 ADRA2B
 ADRA2C
 		Rattus norvegicus 10 µM 5.2 Cerep_11
hAb1 ADRB1 Homo sapiens 10 µM 6.6 Cerep_18
hAb2 ADRB2 Homo sapiens 10 µM -4.5 Cerep_20
rBZD Rattus norvegicus 10 µM 41.6 Cerep_28
hBK2 BDKRB2 Homo sapiens 10 µM 7.1 Cerep_33
hCB2 CNR2 Homo sapiens 10 µM 6.1 Cerep_37
hCCKA CCKAR Homo sapiens 10 µM -19.7 Cerep_39
hCCK2 CCKBR Homo sapiens 10 µM -5.6 Cerep_41
hD1 DRD1 Homo sapiens 10 µM 6.2 Cerep_44
hDAT SLC6A3 Homo sapiens 10 µM 4.5 Cerep_52
hETA EDNRA Homo sapiens 10 µM 5.6 Cerep_54
rGABA Rattus norvegicus 10 µM 21.1 Cerep_57
rSLC6/GABA Rattus norvegicus 10 µM -6.0 Cerep_60
rGlutamate (ionotropic) AMPA Rattus norvegicus 10 µM 7.7 Cerep_64
rGlutamate (ionotropic) kanic acid Rattus norvegicus 10 µM -25.3 Cerep_65
rNMDA Rattus norvegicus 10 µM -9.5 Cerep_66
glyine Rattus norvegicus 10 µM -23.1 Old_Cerep_70
rGlutamate (ionotropic) MDL Rattus norvegicus 10 µM -6.2 Old_Cerep_68
hM1 CHRM1 Homo sapiens 10 µM 2.2 Cerep_91
hM2 CHRM2 Homo sapiens 10 µM 11.0 Cerep_93
hM3 CHRM3 Homo sapiens 10 µM 13.9 Cerep_95
hM4 CHRM4 Homo sapiens 10 µM -3.1 Cerep_96
hM5 CHRM5 Homo sapiens 10 µM -0.6 Cerep_97
hNK1 TACR1 Homo sapiens 10 µM 3.1 Cerep_100
hNK2 TACR2 Homo sapiens 10 µM 9.7 Cerep_102
hNK3 TACR3 Homo sapiens 10 µM -8.7 Cerep_104
hNT1 NTSR1 Homo sapiens 10 µM 12.3 Cerep_109
hOP1 OPRD1 Homo sapiens 10 µM 9.0 Cerep_114
hOP3 OPRM1 Homo sapiens 10 µM 2.2 Cerep_118
rPCP Rattus norvegicus 10 µM -3.5 Cerep_124
rP2X Rattus norvegicus 10 µM 7.0 Old_Cerep_127
h5HT1A HTR1A Homo sapiens 10 µM 8.7 Cerep_131
h5HT2C HTR2C Homo sapiens 10 µM -2.0 Cerep_137
h5HT5A HTR5A Homo sapiens 10 µM 5.7 Cerep_140
h5HT6 HTR6 Homo sapiens 10 µM 4.9 Cerep_142
h5HT7 HTR7 Homo sapiens 10 µM 8.6 Cerep_144
mSST Mus musculus 10 µM 2.8 Cerep_149
hV1a AVPR1A Homo sapiens 10 µM 8.9 Cerep_159
rK_ATP potassium channel Rattus norvegicus 10 µM 2.9 Old_Cerep_165
rK channel Rattus norvegicus 10 µM -9.5 Cerep_166
rSKCa channel Rattus norvegicus 10 µM 7.4 Cerep_167
rCL channel Rattus norvegicus 10 µM -12.3 Old_Cerep_170
hMAOA MAOA Homo sapiens 10 µM 13.8 Old_Cerep_191
hNET SLC6A2 Homo sapiens 10 µM 6.7 Cerep_355
hACHE ACHE Homo sapiens 10 µM 0.2 Cerep_363
h5HT3 HTR3A Homo sapiens 10 µM 3.4 Cerep_411
hEP4 PTGER4 Homo sapiens 10 µM 13.6 Cerep_441
hGR NR3C1 Homo sapiens 10 µM 1.9 Cerep_469
PPAR1C PPARG Homo sapiens 10 µM -2.1 Cerep_641
hH1 HRH1 Homo sapiens 10 µM 2.1 Cerep_870
hAR AR Homo sapiens 10 µM -13.9 Cerep_933
hN muscle type alpha Homo sapiens 10 µM -7.3 Cerep_936
hH2 HRH2 Homo sapiens 10 µM 18.1 Cerep_1208
h5HT2B HTR2B Homo sapiens 10 µM 2.4 Cerep_1333
hEP2 PTGER2 Homo sapiens 10 µM 4.0 Cerep_1955
hIP1 PTGIR Homo sapiens 10 µM -23.4 Cerep_2230
hPR PGR Homo sapiens 10 µM 13.5 Cerep_2341
hLck LCK Homo sapiens 10 µM -2.4 Old_Cerep_2906
hNneuronala4b2 CHRNA4
 CHRNB2
 		Homo sapiens 10 µM -3.0 Cerep_3029
hSigma Homo sapiens 10 µM 1.6 Cerep_3500
hTSPO TSPO Homo sapiens 10 µM 2.8 Cerep_3643
hPDE3A PDE3A Homo sapiens 10 µM 6.0 Cerep_4072
hPDE4D2 PDE4D Homo sapiens 10 µM 27.3 Cerep_4077
hCOX1 PTGS1 Homo sapiens 10 µM 13.0 Cerep_4173
hCOX2 PTGS2 Homo sapiens 10 µM 13.4 Cerep_4186
 

JNJ-42396302

JNJ-42396302 was screened versus other PDE family members.

Conclusion: PDE selectivity > 250 fold: closest hit is PDE1B with Ki = 3.4 µM (257 fold)

Target protein HGNC name Species Ki [µM]
hPDE1B1 PDE1B Homo sapiens 3.4
hPDE2A PDE2A Homo sapiens 32.0
hPDE3A PDE3A Homo sapiens 49.0
hPDE4D3 PDE4D Homo sapiens 15.0
hPDE5A3 PDE5A Homo sapiens 8.5
hPDE6AB PDE6A Homo sapiens 85.0
hPDE7A1 PDE7A Homo sapiens 23.0
hPDE8A1 PDE8A Homo sapiens 41.0
hPDE9A PDE9A Homo sapiens > 33.0
hPDE10A2 PDE10A Homo sapiens 0.0
hPDE11A4 PDE11A Homo sapiens 46.0
 

JNJ-42396302

The radiometric assay was performed in the presence of 10 µM ATP.

Conclusion: Clean panel.

Target protein HGNC name Species % inhibition at 10 µM
CHK1 checkpoint homolog (S. pombe) CHEK1 Homo sapiens -9.0
colony stimulating factor 1 receptor CSF1R Homo sapiens 4.0
conserved helix-loop-helix ubiquitous kinase CHUK Homo sapiens -3.0
cyclin-dependent kinase 1 / clyclinB CDK1 Homo sapiens 5.0
cyclin-dependent kinase 2 / clyclinA CDK2 Homo sapiens 2.0
cyclin-dependent kinase 2 /clyclinE CDK2 Homo sapiens 1.0
cyclin-dependent kinase 3 / cyclinE CDK3 Homo sapiens 7.0
cyclin-dependent kinase 5 / p25 CDK5 Homo sapiens 0.0
cyclin-dependent kinase 5 / p35 CDK5 Homo sapiens -5.0
cyclin-dependent kinase 6 / cyclinD3 CDK6 Homo sapiens 0.0
Cyclin-dependent kinase 7 / cyclinH / MAT CDK7 Homo sapiens 1.0
cyclin-dependent kinase 9 / cyclinT1 CDK9 Homo sapiens -1.0
death-associated protein kinase 1 DAPK1 Homo sapiens -2.0
death-associated protein kinase 2 DAPK2 Homo sapiens -1.0
death-associated protein kinase 3 DAPK3 Homo sapiens -2.0
discoidin domain receptor tyrosine kinase 2 DDR2 Homo sapiens -5.0
doublecortin-like kinase 2 DCLK2 Homo sapiens -6.0
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 DYRK1A Homo sapiens -3.0
dystrophia myotonica-protein kinase DMPK Homo sapiens -15.0
EPH receptor A1 EPHA1 Homo sapiens 7.0
EPH receptor A2 EPHA2 Homo sapiens 7.0
EPH receptor A3 EPHA3 Homo sapiens 4.0
EPH receptor A4 EPHA4 Homo sapiens 2.0
EPH receptor A5 EPHA5 Homo sapiens -9.0
EPH receptor A7 EPHA7 Homo sapiens 0.0
EPH receptor A8 EPHA8 Homo sapiens 0.0
EPH receptor B1 EPHB1 Homo sapiens 2.0
EPH receptor B2 EPHB2 Homo sapiens -18.0
EPH receptor B3 EPHB3 Homo sapiens 3.0
EPH receptor B4 EPHB4 Homo sapiens -35.0
epidermal growth factor receptor EGFR Homo sapiens -19.0
eukaryotic elongation factor-2 kinase EEF2K Homo sapiens -2.0
feline sarcoma oncogene FES Homo sapiens 13.0
fer (fps/fes related) tyrosine kinase FER Homo sapiens 0.0
fibroblast growth factor receptor 1 FGFR1 Homo sapiens 8.0
fibroblast growth factor receptor 2 FGFR2 Homo sapiens -5.0
fibroblast growth factor receptor 3 FGFR3 Homo sapiens -2.0
fibroblast growth factor receptor 4 FGFR4 Homo sapiens -7.0
fms-related tyrosine kinase 1 FLT1 Homo sapiens -5.0
fms-related tyrosine kinase 3 FLT3 Homo sapiens 6.0
fms-related tyrosine kinase 4 FLT4 Homo sapiens -4.0
fyn-related kinase FRK Homo sapiens -7.0
FYN oncogene related to SRC, FGR, YES FYN Homo sapiens 3.0
G protein-coupled receptor kinase 5 GRK5 Homo sapiens -4.0
G protein-coupled receptor kinase 6 GRK6 Homo sapiens 3.0
G protein-coupled receptor kinase 7 GRK7 Homo sapiens 6.0
Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog FGR Homo sapiens 7.0
germ cell associated 2 (haspin) HASPIN Homo sapiens 5.0
glycogen synthase kinase 3 alpha GSK3A Homo sapiens -42.0
glycogen synthase kinase 3 beta GSK3B Homo sapiens -1.0
hemopoietic cell kinase (activated) HCK Homo sapiens -3.0
hemopoietic cell kinase HCK Homo sapiens -2.0
homeodomain interacting protein kinase 1 HIPK1 Homo sapiens 11.0
homeodomain interacting protein kinase 2 HIPK2 Homo sapiens 0.0
homeodomain interacting protein kinase 3 HIPK3 Homo sapiens -6.0
IL2-inducible T-cell kinase ITK Homo sapiens 1.0
inhib of kappa light polypeptide gene enhancer in B-cells, kinase beta IKBKB Homo sapiens -16.0
insulin-like growth factor 1 receptor (activated) IGF1R Homo sapiens 3.0
insulin-like growth factor 1 receptor IGF1R Homo sapiens 1.0
insulin receptor-related receptor INSRR Homo sapiens 10.0
insulin receptor (activated) INSR Homo sapiens -2.0
insulin receptor INSR Homo sapiens -16.0
interleukin-1 receptor-associated kinase 1 IRAK1 Homo sapiens -3.0
interleukin-1 receptor-associated kinase 4 IRAK4 Homo sapiens -1.0
Janus kinase 2 JAK2 Homo sapiens -32.0
Janus kinase 3 JAK3 Homo sapiens -13.0
kinase insert domain receptor KDR Homo sapiens -4.0
LIM domain kinase 1 LIMK1 Homo sapiens -3.0
lymphocyte-specific protein tyrosine kinase (activated) LCK Homo sapiens -4.0
lymphocyte-specific protein tyrosine kinase LCK Homo sapiens 13.0
macrophage stimulating 1 receptor MST1R Homo sapiens 3.0
MAP kinase interacting serine/threonine kinase 2 MKNK2 Homo sapiens 10.0
MAP/microtubule affinity-regulating kinase 1 MARK1 Homo sapiens -6.0
MAP/microtubule affinity-regulating kinase 2 MARK2 Homo sapiens 9.0
mechanistic target of rapamycin / FKBP12 MTOR Homo sapiens 9.0
mechanistic target of rapamycin MTOR Homo sapiens 1.0
met proto-oncogene MET Homo sapiens -6.0
misshapen-like kinase 1 MINK1 Homo sapiens 9.0
mitogen-activated protein kinase-activated protein kinase 2 MAPKAPK2 Homo sapiens -5.0
mitogen-activated protein kinase-activated protein kinase 3 MAPKAPK3 Homo sapiens 3.0
mitogen-activated protein kinase-activated protein kinase 5 MAPKAPK5 Homo sapiens 7.0
mitogen-activated protein kinase 1 (MAPK2) MAPK1 Homo sapiens 4.0
mitogen-activated protein kinase 1 MAPK1 Homo sapiens 1.0
mitogen-activated protein kinase 10 MAPK10 Homo sapiens 18.0
mitogen-activated protein kinase 11 MAPK11 Homo sapiens -2.0
mitogen-activated protein kinase 12 MAPK12 Homo sapiens 2.0
mitogen-activated protein kinase 13 MAPK13 Homo sapiens 4.0
mitogen-activated protein kinase 14 MAPK14 Homo sapiens -4.0
mitogen-activated protein kinase 8 MAPK8 Homo sapiens -3.0
mitogen-activated protein kinase 9 MAPK9 Homo sapiens 0.0
mitogen-activated protein kinase kinase 1 MAP2K1 Homo sapiens -1.0
mitogen-activated protein kinase kinase 6 MAP2K6 Homo sapiens -5.0
mitogen-activated protein kinase kinase 7 MAP2K7 Homo sapiens -11.0
mitogen-activated protein kinase kinase kinase 5 MAP3K5 Homo sapiens -2.0
mitogen-activated protein kinase kinase kinase 7 MAP3K7 Homo sapiens 5.0
mitogen-activated protein kinase kinase kinase 9 MAP3K9 Homo sapiens 5.0
mitogen-activated protein kinase kinase kinase kinase 1 MAP4K1 Homo sapiens 5.5
mitogen-activated protein kinase kinase kinase kinase 2 MAP4K2 Homo sapiens -5.0
muscle, skeletal, receptor tyrosine kinase MUSK Homo sapiens -6.0
myosin light chain kinase MYLK Homo sapiens 2.0
nemo-like kinase NLK Homo sapiens 2.0
neurotrophic tyrosine kinase, receptor, type 1 NTRK1 Homo sapiens 7.0
neurotrophic tyrosine kinase, receptor, type 2 NTRK2 Homo sapiens -5.0
NIMA -related kinase 11 NEK11 Homo sapiens -2.0
NIMA -related kinase 2 NEK2 Homo sapiens -1.0
NIMA -related kinase 3 NEK3 Homo sapiens 4.0
NIMA -related kinase 6 NEK6 Homo sapiens 1.0
NIMA -related kinase 7 NEK7 Homo sapiens 2.0
NUAK family, SNF1-like kinase, 1 NUAK1 Homo sapiens 7.0
p21 protein -activated kinase 2 PAK2 Homo sapiens -3.0
p21 protein -activated kinase 3 PAK3 Homo sapiens -13.0
p21 protein -activated kinase 4 PAK4 Homo sapiens -11.0
p21 protein -activated kinase 5 PAK5 Homo sapiens 7.0
p21 protein -activated kinase 6 PAK6 Homo sapiens 5.0
PAS domain containing serine/threonine kinase PASK Homo sapiens 5.0
phosphoinositide-3-kinase, catalytic, beta polypeptide PIK3CB Homo sapiens 1.0
phosphoinositide-3-kinase, catalytic, delta polypeptide PIK3CD Homo sapiens 1.0
phosphoinositide-3-kinase, catalytic, gamma polypeptide PIK3CG Homo sapiens -4.0
phosphorylase kinase, gamma 2 PHKG2 Homo sapiens -3.0
pim-1 oncogene PIM1 Homo sapiens 10.0
pim-2 oncogene PIM2 Homo sapiens -44.0
pim-3 oncogene PIM3 Homo sapiens 11.0
platelet-derived growth factor receptor, alpha polypeptide PDGFA Homo sapiens -18.0
platelet-derived growth factor receptor, beta polypeptide PDGFB Homo sapiens -3.0
polo-like kinase 1 PLK1 Homo sapiens 0.0
polo-like kinase 2 PLK2 Homo sapiens -7.0
polo-like kinase 3 PLK3 Homo sapiens -2.0
protein kinase C, alpha PRKCA Homo sapiens 15.0
protein kinase C, beta 1 PRKCB Homo sapiens -5.0
protein kinase C, beta 2 PRKCB Homo sapiens 3.0
protein kinase C, delta PRKCD Homo sapiens -2.0
protein kinase C, epsilon PRKCE Homo sapiens -11.0
protein kinase C, eta PRKCH Homo sapiens -2.0
protein kinase C, gamma PRKCG Homo sapiens -4.0
protein kinase C, iota PRKCI Homo sapiens 3.0
protein kinase C, theta PRKCQ Homo sapiens 2.0
protein kinase C, zeta PRKCZ Homo sapiens 5.0
protein kinase D1 PRKD1 Homo sapiens -5.0
protein kinase D2 PRKD2 Homo sapiens 2.0
protein kinase N2 PKN2 Homo sapiens -22.0
protein kinase, AMP-activated, alpha 1 catalytic subunit PRKAA1 Homo sapiens -11.0
protein kinase, AMP-activated, alpha 2 catalytic subunit PRKAA2 Homo sapiens 2.0
protein kinase, cAMP-dependent, catalytic, alpha PRKACA Homo sapiens -37.0
protein kinase, cGMP-dependent, type I PRKG1 Homo sapiens 2.0
protein kinase, cGMP-dependent, type II PRKG2 Homo sapiens 1.0
protein kinase, X-linked PRKX Homo sapiens 4.0
PTK2 protein tyrosine kinase 2 PTK2 Homo sapiens -2.0
PTK2B protein tyrosine kinase 2 beta PTK2B Homo sapiens -4.0
PTK6 protein tyrosine kinase 6 PTK6 Homo sapiens -6.0
receptor-interacting serine-threonine kinase 2 RIPK2 Homo sapiens -6.0
ret proto-oncogene RET Homo sapiens 5.0
Rho-associated, coiled-coil containing protein kinase 1 ROCK1 Homo sapiens -6.0
Rho-associated, coiled-coil containing protein kinase 2 ROCK2 Homo sapiens -3.0
ribosomal protein S6 kinase, 70kDa, polypeptide 1 RPS6KB1 Homo sapiens -7.0
ribosomal protein S6 kinase, 90kDa, polypeptide 1 RPS6KA1 Homo sapiens 9.0
ribosomal protein S6 kinase, 90kDa, polypeptide 2 RPS6KA2 Homo sapiens -16.0
ribosomal protein S6 kinase, 90kDa, polypeptide 3 RPS6KA3 Homo sapiens -20.0
ribosomal protein S6 kinase, 90kDa, polypeptide 4 RPS6KA4 Homo sapiens 2.0
ribosomal protein S6 kinase, 90kDa, polypeptide 5 RPS6KA5 Homo sapiens 3.0
ribosomal protein S6 kinase, 90kDa, polypeptide 6 RPS6KA6 Homo sapiens -10.0
serine/threonine kinase 10 STK10 Homo sapiens 0.0
serine/threonine kinase 11 STK11 Homo sapiens 4.0
serine/threonine kinase 17a STK17A Homo sapiens -9.0
serine/threonine kinase 24 STK24 Homo sapiens 9.0
serine/threonine kinase 3 STK3 Homo sapiens -8.0
serine/threonine kinase 33 STK33 Homo sapiens -1.0
serine/threonine kinase 4 STK4 Homo sapiens -7.0
serum/glucocorticoid regulated kinase 1 SGK1 Homo sapiens -3.0
serum/glucocorticoid regulated kinase 2 SGK2 Homo sapiens -3.0
serum/glucocorticoid regulated kinase family, member 3 SGK3 Homo sapiens 1.0
SFRS protein kinase 1 SRPK1 Homo sapiens -11.0
SFRS protein kinase 2 SRPK2 Homo sapiens -16.0
SFRS protein kinase 3 SRPK3 Homo sapiens -6.0
spleen tyrosine kinase SYK Homo sapiens -7.0
TANK-binding kinase 1 TBK1 Homo sapiens -3.0
TAO kinase 1 TAOK1 Homo sapiens -11.0
TAO kinase 2 TAOK2 Homo sapiens 10.0
TAO kinase 3 TAOK3 Homo sapiens 0.0
tec protein tyrosine kinase (activated) TEC Homo sapiens 7.0
TEK tyrosine kinase, endothelial TEK Homo sapiens 1.0
testis-specific serine kinase 1B TSSK1B Homo sapiens 2.0
testis-specific serine kinase 2 TSSK2 Homo sapiens 1.0
Toll like receptor 4 TLR4 Homo sapiens -5.2
tousled-like kinase 2 TLR2 Homo sapiens -5.0
TXK tyrosine kinase TXK Homo sapiens 6.0
TYRO3 protein tyrosine kinase TYRO3 Homo sapiens 1.0
tyrosine kinase, non-receptor, 2 TNK2 Homo sapiens 0.0
unc-51-like kinase 2 ULK2 Homo sapiens 6.0
unc-51-like kinase 3 ULK3 Homo sapiens -17.0
v-abl Abelson murine leukemia viral oncogene homolog 2 ABL2 Homo sapiens 6.0
v-akt murine thymoma viral oncogene homolog 1 AKT1 Homo sapiens 35.0
v-akt murine thymoma viral oncogene homolog 2 AKT2 Homo sapiens -15.0
v-akt murine thymoma viral oncogene homolog 3 AKT3 Homo sapiens 24.0
v-erb-a erythroblastic leukemia viral oncogene homolog 4 ERBB4 Homo sapiens 9.0
v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog KIT Homo sapiens 4.0
v-raf-1 murine leukemia viral oncogene homolog 1 RAF Homo sapiens 10.0
v-src sarcoma viral oncogene homolog SRC Homo sapiens -5.0
v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1 YES1 Homo sapiens 0.0
v-yes-1 Yamaguchi sarcoma viral related oncogene homolog LYN Homo sapiens -1.0
vaccinia related kinase 2 VRK2 Homo sapiens -4.0
WNK lysine deficient protein kinase 2 WNK2 Homo sapiens -1.0
WNK lysine deficient protein kinase 3 WNK3 Homo sapiens 0.0
zeta-chain associated protein kinase 70kDa ZAP70 Homo sapiens 4.0