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Ogerin

Compound concentration: 10 µM

Receptor	HGNC target name	Inhibition [%] (Primary experimental value)	Ki [nM] (Secondary experimental value)	pKi
5-HT1E	HTR1E	-19.98
5-HT2C	HTR2C	9.32
5-HT3	HTR3A	2.24
5-HT5A	HTR5A	10.59
5-HT6	HTR6	19.37
5-HT7A	HTR7	43.90
Alpha2A	ADRA2A	24.36
Alpha2B	ADRA2B	43.92
Alpha2C	ADRA2C	0.87
GABAA/BZP		32.86
D2	DRD2	10.04
D4	DRD4	4.35
DAT	SLC6A3	18.07
DOR	OPRD1	12.53
KOR	OPRK1	30.22
MOR	OPRM1	11.89
SERT	SLC6A4	4.96
Sigma 1	SIGMAR1	-0.41
5-HT2A	HTR2A	2.78
5-HT2B	HTR2B	81.02	496.36 average (n=2)	6.31
Alpha1A	ADRA1A	25.46
Alpha1B	ADRA1B	-15.43
Alpha1D	ADRA1D	4.63
Beta1	ADRB1	25.52
Beta2	ADRB2	20.72
Beta3	ADRB3	14.82
D1	DRD1	33.66
D3	DRD3	18.89
D5	DRD5	43.88
H1	HRH1	-4.07
H2	HRH2	-17.62
H3	HRH3	-1.93
H4	HRH4	8.30
M1	CHRM1	23.60
M2	CHRM2	23.25
M3	CHRM3	36.00
M4	CHRM4	-9.42
M5	CHRM5	-25.84
NET	SLC6A2	32.14
GABA/PBR		12.89
5-HT1A	HTR1A	9.70
Sigma 2	TMEM97	-27.62
GABAA		19.74
5-HT1B	HTR1B	7.41
5-HT1D	HTR1D	11.15

ZINC32547799

Compound concentration: 10 µM

Receptor	HGNC target name	Inhibition [%] (Primary experimental value)	Ki [nM] (Secondary experimental value)	pKi
Beta1	ADRB1	-3.07
Beta3	ADRB3	17.78
GABAA/BZP		18.30
GABAA		-14.93
GABA/PBR		8.60
D4	DRD4	24.39
D5	DRD5	-13.21
DAT	SLC6A3	-9.76
H4	HRH4	-9.05
KOR	OPRK1	10.82
MOR	OPRM1	8.68
NET	SLC6A2	43.56
5-HT1A	HTR1A	65.55	849.86	6.08
5-HT1B	HTR1B	-2.86
5-HT1D	HTR1D	13.66
5-HT1E	HTR1E	-23.94
5-HT2A	HTR2A	1.28
5-HT2B	HTR2B	41.82
5-HT6	HTR6	26.66
5-HT7A	HTR7	15.88
D1	DRD1	3.99
D2	DRD2	-7.40
D3	DRD3	8.38
Alpha1A	ADRA1A	5.91
Alpha1B	ADRA1B	5.01
Alpha1D	ADRA1D	-8.75
Alpha2A	ADRA2A	7.24
Alpha2B	ADRA2B	21.80
Alpha2C	ADRA2C	1.40
M2	CHRM2	10.77
Sigma 2	TMEM97	12.31
5-HT2C	HTR2C	3.72
5-HT3	HTR3A	37.25
5-HT5A	HTR5A	0.66
Beta2	ADRB2	17.96
DOR	OPRD1	9.20
H1	HRH1	-5.64
H2	HRH2	4.01
H3	HRH3	6.14
M1	CHRM1	35.25
M3	CHRM3	18.27
M4	CHRM4	21.61
M5	CHRM5	12.78
SERT	SLC6A4	9.44
Sigma 1	SIGMAR1	0.95

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