Donated Chemical Probes

Selectivity data for probe SR-318 and control SR-321

SR-318

Compound concentration: 10 µM

Receptor	HGNC target name	Inhibition [%] (Primary experimental value)
5-HT1E	HTR1E	1.00
5-HT2C	HTR2C	10.02
5-HT3	HTR3A	-0.42
5-HT5A	HTR5A	9.60
5-HT6	HTR6	26.83
5-HT7A	HTR7	13.21
Alpha2A	ADRA2A	4.08
Alpha2B	ADRA2B	17.73
Alpha2C	ADRA2C	18.13
Beta3	ADRB3	21.76
GABAA/BZP		13.27
D2	DRD2	14.99
D4	DRD4	-12.86
DAT	SLC6A3	26.76
DOR	OPRD1	24.14
KOR	OPRK1	38.63
MOR	OPRM1	41.23
SERT	SLC6A4	7.75
Sigma 1	SIGMAR1	45.12
5-HT2A	HTR2A	23.68
5-HT2B	HTR2B	19.85
Alpha1A	ADRA1A	36.90
Alpha1B	ADRA1B	8.69
Alpha1D	ADRA1D	21.97
Beta1	ADRB1	25.26
Beta2	ADRB2	6.62
D1	DRD1	-5.64
D3	DRD3	21.22
D5	DRD5	28.37
H1	HRH1	14.73
H2	HRH2	-12.17
H3	HRH3	-2.98
H4	HRH4	-28.04
M1	CHRM1	31.14
M2	CHRM2	22.50
M3	CHRM3	25.22
M4	CHRM4	-4.14
M5	CHRM5	-30.37
NET	SLC6A2	13.52
GABA/PBR		27.61
5-HT1A	HTR1A	-1.43
Sigma 2	TMEM97	45.33
GABAA		21.70
5-HT1B	HTR1B	10.36
5-HT1D	HTR1D	27.59

SR-321

Compound concentration: 10 µM

Receptor	HGNC target name	Inhibition [%] (Primary experimental value)	Ki [nM] (Secondary experimental value)	pKi
5-HT1E	HTR1E	-6.92
5-HT2C	HTR2C	6.21
5-HT3	HTR3A	5.72
5-HT5A	HTR5A	17.03
5-HT6	HTR6	-0.05
5-HT7A	HTR7	25.80
Alpha2A	ADRA2A	-2.46
Alpha2B	ADRA2B	1.13
Alpha2C	ADRA2C	3.68
Beta3	ADRB3	21.70
GABAA/BZP		14.02
D2	DRD2	15.84
D4	DRD4	21.69
DAT	SLC6A3	22.34
DOR	OPRD1	12.88
KOR	OPRK1	80.21	> 10000.00 average (n=2)	< 5.00
MOR	OPRM1	19.37
SERT	SLC6A4	0.18
Sigma 1	SIGMAR1	20.15
5-HT2A	HTR2A	8.57
5-HT2B	HTR2B	3.69
Alpha1A	ADRA1A	17.95
Alpha1D	ADRA1D	10.06
Beta1	ADRB1	21.85
Beta2	ADRB2	12.43
D1	DRD1	5.56
D3	DRD3	2.65
D5	DRD5	23.16
GABAA		-4.39
H1	HRH1	63.00	> 10000.00 average (n=2)	< 5.00
H2	HRH2	-2.78
H3	HRH3	9.12
H4	HRH4	-25.60
M1	CHRM1	11.80
M2	CHRM2	19.32
M3	CHRM3	19.48
M4	CHRM4	20.06
M5	CHRM5	-4.46
NET	SLC6A2	-1.78
GABA/PBR		-16.48
5-HT1A	HTR1A	20.05
Alpha1B	ADRA1B	-3.62
Sigma 2	TMEM97	54.76	2887.53 average (n=2)	5.55
5-HT1B	HTR1B	9.89
5-HT1D	HTR1D	-8.35

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Primary results are shown as '% Ctrl', i.e. the negative control (DMSO) is equal 100% control and the positive control (control compound) is equal 0% control. For compounds showing less than 50% of control in the primary screening assay, a Kd will be determined. Note: It cannot be excluded that 0 % control values are due to assay artefacts.

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Jump to control KinomeScan data

SR-318

HGNC target name	DiscoverX gene symbol of kinase	% Control	Compound Concentration [nM]
AAK1	AAK1	100.0	100
ABL1	ABL1-phosphorylated	97.0	100
CSNK1D	CSNK1D	100.0	100
ABL2	ABL2	100.0	100
ACVR1	ACVR1	100.0	100
ACVR1B	ACVR1B	100.0	100
ACVR2A	ACVR2A	100.0	100
ACVR2B	ACVR2B	100.0	100
ACVRL1	ACVRL1	100.0	100
COQ8A	ADCK3	100.0	100
COQ8B	ADCK4	100.0	100
AKT1	AKT1	100.0	100
AKT2	AKT2	96.0	100
AKT3	AKT3	78.0	100
ALK	ALK(L1196M)	100.0	100
PRKAA1	AMPK-alpha1	100.0	100
PRKAA2	AMPK-alpha2	100.0	100
ANKK1	ANKK1	100.0	100
NUAK1	ARK5	100.0	100
MAP3K5	ASK1	81.0	100
MAP3K6	ASK2	100.0	100
AURKA	AURKA	100.0	100
AURKB	AURKB	81.0	100
AURKC	AURKC	100.0	100
AXL	AXL	87.0	100
BMP2K	BIKE	100.0	100
BLK	BLK	81.0	100
BMPR1A	BMPR1A	100.0	100
BMPR1B	BMPR1B	100.0	100
BMPR2	BMPR2	100.0	100
BMX	BMX	100.0	100
BRAF	BRAF(V600E)	100.0	100
PTK6	BRK	96.0	100
BRSK1	BRSK1	94.0	100
BRSK2	BRSK2	79.0	100
BTK	BTK	100.0	100
BUB1	BUB1	86.0	100
CAMK1	CAMK1	100.0	100
PNCK	CAMK1B	100.0	100
CAMK1D	CAMK1D	93.0	100
CAMK1G	CAMK1G	100.0	100
CAMK2A	CAMK2A	100.0	100
CAMK2B	CAMK2B	100.0	100
CAMK2D	CAMK2D	100.0	100
CAMK2G	CAMK2G	100.0	100
CAMK4	CAMK4	98.0	100
CAMKK1	CAMKK1	100.0	100
CAMKK2	CAMKK2	100.0	100
CASK	CASK	78.0	100
CDK11B	CDC2L1	100.0	100
CDK11A	CDC2L2	100.0	100
CDK13	CDC2L5	79.0	100
CDK19	CDK11	99.0	100
CDK2	CDK2	96.0	100
CDK3	CDK3	100.0	100
CDK4	CDK4-cyclinD3	100.0	100
CDK5	CDK5	100.0	100
CDK7	CDK7	100.0	100
CDK8	CDK8	96.0	100
CDK9	CDK9	100.0	100
CDKL1	CDKL1	100.0	100
CDKL2	CDKL2	93.0	100
CDKL3	CDKL3	97.0	100
CDKL5	CDKL5	100.0	100
CHEK1	CHEK1	100.0	100
CHEK2	CHEK2	88.0	100
CIT	CIT	100.0	100
CLK1	CLK1	100.0	100
CLK2	CLK2	100.0	100
CLK3	CLK3	95.0	100
CLK4	CLK4	96.0	100
CSF1R	CSF1R-autoinhibited	100.0	100
CSK	CSK	100.0	100
CSNK1A1	CSNK1A1	100.0	100
CSNK1A1L	CSNK1A1L	98.0	100
CSNK1E	CSNK1E	98.0	100
CSNK1G1	CSNK1G1	100.0	100
CSNK1G2	CSNK1G2	94.0	100
CSNK1G3	CSNK1G3	100.0	100
CSNK2A1	CSNK2A1	70.0	100
CSNK2A2	CSNK2A2	100.0	100
MATK	CTK	100.0	100
DAPK1	DAPK1	92.0	100
DAPK2	DAPK2	100.0	100
DAPK3	DAPK3	100.0	100
DCLK1	DCAMKL1	100.0	100
DCLK2	DCAMKL2	100.0	100
DCLK3	DCAMKL3	100.0	100
DDR1	DDR1	43.0	100
DDR2	DDR2	56.0	100
MAP3K12	DLK	100.0	100
DMPK	DMPK	77.0	100
CDC42BPG	DMPK2	100.0	100
STK17A	DRAK1	100.0	100
STK17B	DRAK2	94.0	100
DYRK1A	DYRK1A	100.0	100
DYRK1B	DYRK1B	100.0	100
DYRK2	DYRK2	97.0	100
EGFR	EGFR(T790M)	100.0	100
EIF2AK1	EIF2AK1	100.0	100
EPHA1	EPHA1	100.0	100
EPHA2	EPHA2	100.0	100
EPHA3	EPHA3	100.0	100
EPHA4	EPHA4	100.0	100
EPHA5	EPHA5	100.0	100
EPHA6	EPHA6	94.0	100
EPHA7	EPHA7	100.0	100
EPHA8	EPHA8	100.0	100
EPHB1	EPHB1	100.0	100
EPHB2	EPHB2	100.0	100
EPHB3	EPHB3	96.0	100
EPHB4	EPHB4	100.0	100
EPHB6	EPHB6	100.0	100
ERBB2	ERBB2	100.0	100
ERBB3	ERBB3	44.0	100
ERBB4	ERBB4	89.0	100
MAPK3	ERK1	94.0	100
MAPK1	ERK2	100.0	100
MAPK6	ERK3	92.0	100
MAPK4	ERK4	100.0	100
MAPK7	ERK5	78.0	100
MAPK15	ERK8	100.0	100
ERN1	ERN1	100.0	100
PTK2	FAK	99.0	100
FER	FER	90.0	100
FES	FES	100.0	100
FGFR1	FGFR1	71.0	100
FGFR2	FGFR2	100.0	100
FGFR3	FGFR3(G697C)	87.0	100
FGFR4	FGFR4	97.0	100
FGR	FGR	100.0	100
FLT1	FLT1	100.0	100
FLT3	FLT3-autoinhibited	100.0	100
FLT4	FLT4	100.0	100
FRK	FRK	100.0	100
FYN	FYN	100.0	100
GAK	GAK	100.0	100
EIF2AK4	GCN2(Kin.Dom.2,S808G)	100.0	100
GRK1	GRK1	100.0	100
GRK2	GRK2	100.0	100
GRK3	GRK3	100.0	100
GRK4	GRK4	100.0	100
GRK7	GRK7	100.0	100
GSK3A	GSK3A	100.0	100
GSK3B	GSK3B	100.0	100
HASPIN	HASPIN	100.0	100
HCK	HCK	100.0	100
HIPK1	HIPK1	100.0	100
HIPK2	HIPK2	100.0	100
HIPK3	HIPK3	100.0	100
HIPK4	HIPK4	100.0	100
MAP4K1	HPK1	99.0	100
HUNK	HUNK	100.0	100
CILK1	ICK	100.0	100
IGF1R	IGF1R	98.0	100
CHUK	IKK-alpha	100.0	100
IKBKB	IKK-beta	100.0	100
IKBKE	IKK-epsilon	100.0	100
INSR	INSR	100.0	100
INSRR	INSRR	100.0	100
IRAK1	IRAK1	86.0	100
IRAK3	IRAK3	94.0	100
IRAK4	IRAK4	100.0	100
ITK	ITK	93.0	100
JAK1	JAK1(JH2domain-pseudokinase)	100.0	100
JAK2	JAK2(JH1domain-catalytic)	100.0	100
JAK3	JAK3(JH1domain-catalytic)	100.0	100
MAPK8	JNK1	100.0	100
MAPK9	JNK2	100.0	100
MAPK10	JNK3	100.0	100
KIT	KIT-autoinhibited	100.0	100
LATS1	LATS1	100.0	100
LATS2	LATS2	100.0	100
LCK	LCK	82.0	100
LIMK1	LIMK1	100.0	100
LIMK2	LIMK2	100.0	100
STK11	LKB1	100.0	100
STK10	LOK	100.0	100
LRRK2	LRRK2(G2019S)	100.0	100
LTK	LTK	100.0	100
LYN	LYN	100.0	100
MAP3K13	LZK	100.0	100
MAK	MAK	100.0	100
MAP3K1	MAP3K1	96.0	100
MAP3K15	MAP3K15	100.0	100
MAP3K2	MAP3K2	100.0	100
MAP3K3	MAP3K3	100.0	100
MAP3K4	MAP3K4	81.0	100
MAP4K2	MAP4K2	94.0	100
MAP4K3	MAP4K3	100.0	100
MAP4K4	MAP4K4	87.0	100
MAP4K5	MAP4K5	100.0	100
MAPKAPK2	MAPKAPK2	100.0	100
MAPKAPK5	MAPKAPK5	93.0	100
MARK1	MARK1	79.0	100
MARK2	MARK2	65.0	100
MARK3	MARK3	78.0	100
MARK4	MARK4	76.0	100
MAST1	MAST1	100.0	100
MAP2K1	MEK1	100.0	100
MAP2K2	MEK2	100.0	100
MAP2K3	MEK3	85.0	100
MAP2K4	MEK4	100.0	100
MAP2K5	MEK5	100.0	100
MAP2K6	MEK6	79.0	100
MELK	MELK	92.0	100
MERTK	MERTK	100.0	100
MET	MET(Y1235D)	94.0	100
MINK1	MINK	100.0	100
MAP2K7	MKK7	99.0	100
MKNK1	MKNK1	82.0	100
MKNK2	MKNK2	100.0	100
MYLK3	MLCK	100.0	100
MAP3K9	MLK1	96.0	100
MAP3K10	MLK2	85.0	100
MAP3K11	MLK3	76.0	100
CDC42BPA	MRCKA	100.0	100
CDC42BPB	MRCKB	100.0	100
STK4	MST1	100.0	100
MST1R	MST1R	100.0	100
STK3	MST2	100.0	100
STK24	MST3	91.0	100
STK26	MST4	97.0	100
MTOR	MTOR	100.0	100
MUSK	MUSK	97.0	100
MYLK	MYLK	68.0	100
MYLK2	MYLK2	100.0	100
MYLK4	MYLK4	100.0	100
MYO3A	MYO3A	100.0	100
MYO3B	MYO3B	100.0	100
STK38	NDR1	96.0	100
STK38L	NDR2	44.0	100
NEK1	NEK1	84.0	100
NEK10	NEK10	100.0	100
NEK11	NEK11	94.0	100
NEK2	NEK2	100.0	100
NEK3	NEK3	100.0	100
NEK4	NEK4	100.0	100
NEK5	NEK5	99.0	100
NEK6	NEK6	100.0	100
NEK7	NEK7	99.0	100
NEK9	NEK9	100.0	100
MAP3K14	NIK	100.0	100
NIM1K	NIM1	81.0	100
NLK	NLK	96.0	100
OXSR1	OSR1	100.0	100
MAPK14	p38-alpha	24.0	100
MAPK11	p38-beta	3.4	100
MAPK13	p38-delta	100.0	100
MAPK12	p38-gamma	100.0	100
PAK1	PAK1	100.0	100
PAK2	PAK2	66.0	100
PAK3	PAK3	100.0	100
PAK4	PAK4	99.0	100
PAK6	PAK6	100.0	100
PAK5	PAK7	100.0	100
CDK16	PCTK1	97.0	100
CDK17	PCTK2	78.0	100
CDK18	PCTK3	100.0	100
PDGFRA	PDGFRA	100.0	100
PDGFRB	PDGFRB	100.0	100
PDPK1	PDPK1	100.0	100
CDPK1	PFCDPK1(P.falciparum)	86.0	100
PK5	PFPK5(P.falciparum)	100.0	100
CDK15	PFTAIRE2	95.0	100
CDK14	PFTK1	100.0	100
PHKG1	PHKG1	90.0	100
PHKG2	PHKG2	100.0	100
PIK3C2B	PIK3C2B	99.0	100
PIK3C2G	PIK3C2G	100.0	100
PIK3CA	PIK3CA(Q546K)	96.0	100
PIK3CB	PIK3CB	100.0	100
PIK3CD	PIK3CD	94.0	100
PIK3CG	PIK3CG	100.0	100
PI4KB	PIK4CB	100.0	100
PIKFYVE	PIKFYVE	100.0	100
PIM1	PIM1	93.0	100
PIM2	PIM2	100.0	100
PIM3	PIM3	91.0	100
PIP5K1A	PIP5K1A	100.0	100
PIP5K1C	PIP5K1C	93.0	100
PIP4K2B	PIP5K2B	100.0	100
PIP4K2C	PIP5K2C	100.0	100
PRKACA	PKAC-alpha	100.0	100
PRKACB	PKAC-beta	82.0	100
PKMYT1	PKMYT1	100.0	100
PKN1	PKN1	96.0	100
PKN2	PKN2	78.0	100
PKNB	PKNB(M.tuberculosis)	100.0	100
PLK1	PLK1	100.0	100
PLK2	PLK2	100.0	100
PLK3	PLK3	100.0	100
PLK4	PLK4	100.0	100
PRKCD	PRKCD	88.0	100
PRKCE	PRKCE	100.0	100
PRKCH	PRKCH	98.0	100
PRKCI	PRKCI	97.0	100
PRKCQ	PRKCQ	100.0	100
PRKD1	PRKD1	100.0	100
PRKD2	PRKD2	100.0	100
PRKD3	PRKD3	92.0	100
PRKG1	PRKG1	74.0	100
PRKG2	PRKG2	96.0	100
EIF2AK2	PRKR	54.0	100
PRKX	PRKX	87.0	100
PRPF4B	PRP4	100.0	100
PTK2B	PYK2	99.0	100
SIK3	QSK	94.0	100
RAF1	RAF1	100.0	100
RET	RET(V804M)	98.0	100
RIOK1	RIOK1	95.0	100
RIOK2	RIOK2	92.0	100
RIOK3	RIOK3	100.0	100
RIPK1	RIPK1	100.0	100
RIPK2	RIPK2	96.0	100
RIPK4	RIPK4	100.0	100
DSTYK	RIPK5	100.0	100
ROCK1	ROCK1	100.0	100
ROCK2	ROCK2	100.0	100
ROS1	ROS1	83.0	100
RPS6KA4	RPS6KA4(Kin.Dom.2-C-terminal)	98.0	100
RPS6KA5	RPS6KA5(Kin.Dom.2-C-terminal)	23.0	100
RPS6KA1	RSK1(Kin.Dom.2-C-terminal)	92.0	100
RPS6KA3	RSK2(Kin.Dom.2-C-terminal)	92.0	100
RPS6KA2	RSK3(Kin.Dom.2-C-terminal)	90.0	100
RPS6KA6	RSK4(Kin.Dom.2-C-terminal)	61.0	100
RPS6KB1	S6K1	100.0	100
SBK1	SBK1	82.0	100
SGK1	SGK	100.0	100
SBK3	SgK110	87.0	100
SGK2	SGK2	72.0	100
SGK3	SGK3	90.0	100
SIK1	SIK	100.0	100
SIK2	SIK2	100.0	100
SLK	SLK	80.0	100
NUAK2	SNARK	100.0	100
SNRK	SNRK	91.0	100
SRC	SRC	100.0	100
SRMS	SRMS	100.0	100
SRPK1	SRPK1	90.0	100
SRPK2	SRPK2	100.0	100
SRPK3	SRPK3	100.0	100
STK16	STK16	100.0	100
STK33	STK33	96.0	100
STK35	STK35	100.0	100
STK36	STK36	100.0	100
STK39	STK39	96.0	100
SYK	SYK	74.0	100
MAP3K7	TAK1	100.0	100
TAOK1	TAOK1	91.0	100
TAOK2	TAOK2	100.0	100
TAOK3	TAOK3	96.0	100
TBK1	TBK1	96.0	100
TEC	TEC	100.0	100
TESK1	TESK1	100.0	100
TGFBR1	TGFBR1	100.0	100
TGFBR2	TGFBR2	99.0	100
TIE1	TIE1	100.0	100
TEK	TIE2	100.0	100
TLK1	TLK1	77.0	100
TLK2	TLK2	100.0	100
TNIK	TNIK	100.0	100
TNK1	TNK1	91.0	100
TNK2	TNK2	89.0	100
TNNI3K	TNNI3K	100.0	100
NTRK1	TRKA	100.0	100
NTRK2	TRKB	85.0	100
NTRK3	TRKC	97.0	100
TRPM6	TRPM6	100.0	100
TSSK1B	TSSK1B	81.0	100
TSSK3	TSSK3	100.0	100
TTK	TTK	100.0	100
TXK	TXK	83.0	100
TYK2	TYK2(JH2domain-pseudokinase)	88.0	100
TYRO3	TYRO3	100.0	100
ULK1	ULK1	100.0	100
ULK2	ULK2	100.0	100
ULK3	ULK3	100.0	100
KDR	VEGFR2	100.0	100
PIK3C3	VPS34	99.0	100
VRK2	VRK2	92.0	100
WEE1	WEE1	100.0	100
WEE2	WEE2	100.0	100
WNK1	WNK1	100.0	100
WNK2	WNK2	100.0	100
WNK3	WNK3	92.0	100
WNK4	WNK4	80.0	100
STK32A	YANK1	96.0	100
STK32B	YANK2	100.0	100
STK32C	YANK3	90.0	100
YES1	YES	100.0	100
STK25	YSK1	82.0	100
MAP3K19	YSK4	77.0	100
MAP3K20	ZAK	42.0	100
ZAP70	ZAP70	100.0	100

SR-321

HGNC target name	DiscoverX gene symbol of kinase	% Control	Compound Concentration [nM]
AAK1	AAK1	100.0	100
ABL1	ABL1-phosphorylated	88.0	100
ABL2	ABL2	87.0	100
ACVR1	ACVR1	100.0	100
ACVR1B	ACVR1B	100.0	100
ACVR2A	ACVR2A	83.0	100
ACVR2B	ACVR2B	96.0	100
ACVRL1	ACVRL1	100.0	100
COQ8A	ADCK3	100.0	100
COQ8B	ADCK4	100.0	100
AKT1	AKT1	100.0	100
AKT2	AKT2	100.0	100
AKT3	AKT3	97.0	100
ALK	ALK(L1196M)	100.0	100
PRKAA1	AMPK-alpha1	100.0	100
PRKAA2	AMPK-alpha2	100.0	100
ANKK1	ANKK1	100.0	100
NUAK1	ARK5	100.0	100
MAP3K5	ASK1	91.0	100
MAP3K6	ASK2	100.0	100
AURKA	AURKA	100.0	100
AURKB	AURKB	95.0	100
AURKC	AURKC	100.0	100
AXL	AXL	95.0	100
BMP2K	BIKE	100.0	100
BLK	BLK	100.0	100
BMPR1A	BMPR1A	100.0	100
BMPR1B	BMPR1B	92.0	100
BMPR2	BMPR2	100.0	100
BMX	BMX	75.0	100
BRAF	BRAF(V600E)	100.0	100
PTK6	BRK	97.0	100
BRSK1	BRSK1	100.0	100
BRSK2	BRSK2	100.0	100
BTK	BTK	100.0	100
BUB1	BUB1	100.0	100
CAMK1	CAMK1	100.0	100
PNCK	CAMK1B	79.0	100
CAMK1D	CAMK1D	100.0	100
CAMK1G	CAMK1G	100.0	100
CAMK2A	CAMK2A	100.0	100
CAMK2B	CAMK2B	96.0	100
CAMK2D	CAMK2D	100.0	100
CAMK2G	CAMK2G	100.0	100
CAMK4	CAMK4	100.0	100
CAMKK1	CAMKK1	100.0	100
CAMKK2	CAMKK2	100.0	100
CASK	CASK	100.0	100
CDK11B	CDC2L1	100.0	100
CDK11A	CDC2L2	100.0	100
CDK13	CDC2L5	100.0	100
CDK19	CDK11	96.0	100
CDK2	CDK2	96.0	100
CDK3	CDK3	100.0	100
CDK4	CDK4-cyclinD3	100.0	100
CDK5	CDK5	88.0	100
CDK7	CDK7	100.0	100
CDK8	CDK8	97.0	100
CDK9	CDK9	100.0	100
CDKL1	CDKL1	80.0	100
CDKL2	CDKL2	100.0	100
CDKL3	CDKL3	100.0	100
CDKL5	CDKL5	100.0	100
CHEK1	CHEK1	100.0	100
CHEK2	CHEK2	100.0	100
CIT	CIT	86.0	100
CLK1	CLK1	96.0	100
CLK2	CLK2	100.0	100
CLK3	CLK3	100.0	100
CLK4	CLK4	100.0	100
CSF1R	CSF1R-autoinhibited	100.0	100
CSK	CSK	100.0	100
CSNK1A1	CSNK1A1	99.0	100
CSNK1A1L	CSNK1A1L	94.0	100
CSNK1D	CSNK1D	100.0	100
CSNK1E	CSNK1E	100.0	100
CSNK1G1	CSNK1G1	100.0	100
CSNK1G2	CSNK1G2	96.0	100
CSNK1G3	CSNK1G3	100.0	100
CSNK2A1	CSNK2A1	94.0	100
CSNK2A2	CSNK2A2	88.0	100
MATK	CTK	100.0	100
DAPK1	DAPK1	100.0	100
DAPK2	DAPK2	98.0	100
DAPK3	DAPK3	92.0	100
DCLK1	DCAMKL1	100.0	100
DCLK2	DCAMKL2	100.0	100
DCLK3	DCAMKL3	100.0	100
DDR1	DDR1	100.0	100
DDR2	DDR2	100.0	100
MAP3K12	DLK	100.0	100
DMPK	DMPK	83.0	100
CDC42BPG	DMPK2	99.0	100
STK17A	DRAK1	100.0	100
STK17B	DRAK2	100.0	100
DYRK1A	DYRK1A	99.0	100
DYRK1B	DYRK1B	100.0	100
DYRK2	DYRK2	100.0	100
EGFR	EGFR(T790M)	97.0	100
EIF2AK1	EIF2AK1	95.0	100
EPHA1	EPHA1	100.0	100
EPHA2	EPHA2	80.0	100
EPHA3	EPHA3	91.0	100
EPHA4	EPHA4	70.0	100
EPHA5	EPHA5	92.0	100
EPHA6	EPHA6	88.0	100
EPHA7	EPHA7	86.0	100
EPHA8	EPHA8	95.0	100
EPHB1	EPHB1	89.0	100
EPHB2	EPHB2	100.0	100
EPHB3	EPHB3	79.0	100
EPHB4	EPHB4	95.0	100
EPHB6	EPHB6	100.0	100
ERBB2	ERBB2	100.0	100
ERBB3	ERBB3	100.0	100
ERBB4	ERBB4	100.0	100
MAPK3	ERK1	93.0	100
MAPK1	ERK2	93.0	100
MAPK6	ERK3	100.0	100
MAPK4	ERK4	100.0	100
MAPK7	ERK5	100.0	100
MAPK15	ERK8	100.0	100
ERN1	ERN1	94.0	100
PTK2	FAK	100.0	100
FER	FER	98.0	100
FES	FES	100.0	100
FGFR1	FGFR1	100.0	100
FGFR2	FGFR2	100.0	100
FGFR3	FGFR3(G697C)	100.0	100
FGFR4	FGFR4	100.0	100
FGR	FGR	95.0	100
FLT1	FLT1	100.0	100
FLT3	FLT3-autoinhibited	100.0	100
FLT4	FLT4	100.0	100
FRK	FRK	77.0	100
FYN	FYN	86.0	100
GAK	GAK	100.0	100
EIF2AK4	GCN2(Kin.Dom.2,S808G)	100.0	100
GRK1	GRK1	94.0	100
GRK2	GRK2	100.0	100
GRK3	GRK3	100.0	100
GRK4	GRK4	100.0	100
GRK7	GRK7	100.0	100
GSK3A	GSK3A	100.0	100
GSK3B	GSK3B	100.0	100
HASPIN	HASPIN	100.0	100
HCK	HCK	100.0	100
HIPK1	HIPK1	99.0	100
HIPK2	HIPK2	100.0	100
HIPK3	HIPK3	88.0	100
HIPK4	HIPK4	100.0	100
MAP4K1	HPK1	100.0	100
HUNK	HUNK	100.0	100
CILK1	ICK	79.0	100
IGF1R	IGF1R	100.0	100
CHUK	IKK-alpha	100.0	100
IKBKB	IKK-beta	100.0	100
IKBKE	IKK-epsilon	78.0	100
INSR	INSR	100.0	100
INSRR	INSRR	100.0	100
IRAK1	IRAK1	100.0	100
IRAK3	IRAK3	100.0	100
IRAK4	IRAK4	100.0	100
ITK	ITK	100.0	100
JAK1	JAK1(JH2domain-pseudokinase)	89.0	100
JAK2	JAK2(JH1domain-catalytic)	100.0	100
JAK3	JAK3(JH1domain-catalytic)	100.0	100
MAPK8	JNK1	99.0	100
MAPK9	JNK2	85.0	100
MAPK10	JNK3	100.0	100
KIT	KIT-autoinhibited	100.0	100
LATS1	LATS1	100.0	100
LATS2	LATS2	97.0	100
LCK	LCK	100.0	100
LIMK1	LIMK1	100.0	100
LIMK2	LIMK2	100.0	100
STK11	LKB1	100.0	100
STK10	LOK	100.0	100
LRRK2	LRRK2(G2019S)	100.0	100
LTK	LTK	100.0	100
LYN	LYN	100.0	100
MAP3K13	LZK	100.0	100
MAK	MAK	100.0	100
MAP3K1	MAP3K1	65.0	100
MAP3K15	MAP3K15	84.0	100
MAP3K2	MAP3K2	100.0	100
MAP3K3	MAP3K3	100.0	100
MAP3K4	MAP3K4	100.0	100
MAP4K2	MAP4K2	100.0	100
MAP4K3	MAP4K3	78.0	100
MAP4K4	MAP4K4	81.0	100
MAP4K5	MAP4K5	88.0	100
MAPKAPK2	MAPKAPK2	100.0	100
MAPKAPK5	MAPKAPK5	100.0	100
MARK1	MARK1	100.0	100
MARK2	MARK2	100.0	100
MARK3	MARK3	94.0	100
MARK4	MARK4	98.0	100
MAST1	MAST1	88.0	100
MAP2K1	MEK1	89.0	100
MAP2K2	MEK2	93.0	100
MAP2K3	MEK3	100.0	100
MAP2K4	MEK4	100.0	100
MAP2K5	MEK5	73.0	100
MAP2K6	MEK6	79.0	100
MELK	MELK	80.0	100
MERTK	MERTK	100.0	100
MET	MET(Y1235D)	100.0	100
MINK1	MINK	97.0	100
MAP2K7	MKK7	100.0	100
MKNK1	MKNK1	98.0	100
MKNK2	MKNK2	100.0	100
MYLK3	MLCK	92.0	100
MAP3K9	MLK1	100.0	100
MAP3K10	MLK2	87.0	100
MAP3K11	MLK3	100.0	100
CDC42BPA	MRCKA	100.0	100
CDC42BPB	MRCKB	100.0	100
STK4	MST1	100.0	100
MST1R	MST1R	100.0	100
STK3	MST2	100.0	100
STK24	MST3	100.0	100
STK26	MST4	93.0	100
MTOR	MTOR	100.0	100
MUSK	MUSK	100.0	100
MYLK	MYLK	100.0	100
MYLK2	MYLK2	100.0	100
MYLK4	MYLK4	100.0	100
MYO3A	MYO3A	98.0	100
MYO3B	MYO3B	100.0	100
STK38	NDR1	93.0	100
STK38L	NDR2	20.0	100
NEK1	NEK1	58.0	100
NEK10	NEK10	100.0	100
NEK11	NEK11	100.0	100
NEK2	NEK2	100.0	100
NEK3	NEK3	100.0	100
NEK4	NEK4	100.0	100
NEK5	NEK5	100.0	100
NEK6	NEK6	83.0	100
NEK7	NEK7	97.0	100
NEK9	NEK9	100.0	100
MAP3K14	NIK	90.0	100
NIM1K	NIM1	70.0	100
NLK	NLK	100.0	100
OXSR1	OSR1	91.0	100
MAPK14	p38-alpha	100.0	100
MAPK11	p38-beta	100.0	100
MAPK13	p38-delta	100.0	100
MAPK12	p38-gamma	100.0	100
PAK1	PAK1	92.0	100
PAK2	PAK2	100.0	100
PAK3	PAK3	100.0	100
PAK4	PAK4	100.0	100
PAK6	PAK6	100.0	100
PAK5	PAK7	100.0	100
CDK16	PCTK1	100.0	100
CDK17	PCTK2	100.0	100
CDK18	PCTK3	100.0	100
PDGFRA	PDGFRA	92.0	100
PDGFRB	PDGFRB	100.0	100
PDPK1	PDPK1	100.0	100
CDPK1	PFCDPK1(P.falciparum)	100.0	100
PK5	PFPK5(P.falciparum)	100.0	100
CDK15	PFTAIRE2	77.0	100
CDK14	PFTK1	100.0	100
PHKG1	PHKG1	100.0	100
PHKG2	PHKG2	100.0	100
PIK3C2B	PIK3C2B	86.0	100
PIK3C2G	PIK3C2G	100.0	100
PIK3CA	PIK3CA(Q546K)	67.0	100
PIK3CB	PIK3CB	100.0	100
PIK3CD	PIK3CD	100.0	100
PIK3CG	PIK3CG	95.0	100
PI4KB	PIK4CB	77.0	100
PIKFYVE	PIKFYVE	65.0	100
PIM1	PIM1	100.0	100
PIM2	PIM2	100.0	100
PIM3	PIM3	100.0	100
PIP5K1A	PIP5K1A	100.0	100
PIP5K1C	PIP5K1C	90.0	100
PIP4K2B	PIP5K2B	96.0	100
PIP4K2C	PIP5K2C	99.0	100
PRKACA	PKAC-alpha	100.0	100
PRKACB	PKAC-beta	100.0	100
PKMYT1	PKMYT1	77.0	100
PKN1	PKN1	100.0	100
PKN2	PKN2	100.0	100
PKNB	PKNB(M.tuberculosis)	100.0	100
PLK1	PLK1	93.0	100
PLK2	PLK2	100.0	100
PLK3	PLK3	100.0	100
PLK4	PLK4	96.0	100
PRKCD	PRKCD	100.0	100
PRKCE	PRKCE	88.0	100
PRKCH	PRKCH	100.0	100
PRKCI	PRKCI	100.0	100
PRKCQ	PRKCQ	100.0	100
PRKD1	PRKD1	100.0	100
PRKD2	PRKD2	100.0	100
PRKD3	PRKD3	99.0	100
PRKG1	PRKG1	100.0	100
PRKG2	PRKG2	89.0	100
EIF2AK2	PRKR	64.0	100
PRKX	PRKX	100.0	100
PRPF4B	PRP4	100.0	100
PTK2B	PYK2	93.0	100
SIK3	QSK	76.0	100
RAF1	RAF1	99.0	100
RET	RET(V804M)	100.0	100
RIOK1	RIOK1	100.0	100
RIOK2	RIOK2	100.0	100
RIOK3	RIOK3	100.0	100
RIPK1	RIPK1	89.0	100
RIPK2	RIPK2	97.0	100
RIPK4	RIPK4	58.0	100
DSTYK	RIPK5	100.0	100
ROCK1	ROCK1	100.0	100
ROCK2	ROCK2	100.0	100
ROS1	ROS1	100.0	100
RPS6KA4	RPS6KA4(Kin.Dom.2-C-terminal)	90.0	100
RPS6KA5	RPS6KA5(Kin.Dom.2-C-terminal)	82.0	100
RPS6KA1	RSK1(Kin.Dom.2-C-terminal)	100.0	100
RPS6KA3	RSK2(Kin.Dom.2-C-terminal)	100.0	100
RPS6KA2	RSK3(Kin.Dom.2-C-terminal)	96.0	100
RPS6KA6	RSK4(Kin.Dom.2-C-terminal)	92.0	100
RPS6KB1	S6K1	96.0	100
SBK1	SBK1	100.0	100
SGK1	SGK	100.0	100
SBK3	SgK110	100.0	100
SGK2	SGK2	95.0	100
SGK3	SGK3	92.0	100
SIK1	SIK	91.0	100
SIK2	SIK2	100.0	100
SLK	SLK	100.0	100
NUAK2	SNARK	100.0	100
SNRK	SNRK	100.0	100
SRC	SRC	100.0	100
SRMS	SRMS	93.0	100
SRPK1	SRPK1	95.0	100
SRPK2	SRPK2	100.0	100
SRPK3	SRPK3	100.0	100
STK16	STK16	100.0	100
STK33	STK33	87.0	100
STK35	STK35	100.0	100
STK36	STK36	100.0	100
STK39	STK39	100.0	100
SYK	SYK	100.0	100
MAP3K7	TAK1	89.0	100
TAOK1	TAOK1	96.0	100
TAOK2	TAOK2	89.0	100
TAOK3	TAOK3	99.0	100
TBK1	TBK1	100.0	100
TEC	TEC	94.0	100
TESK1	TESK1	100.0	100
TGFBR1	TGFBR1	89.0	100
TGFBR2	TGFBR2	100.0	100
TIE1	TIE1	100.0	100
TEK	TIE2	100.0	100
TLK1	TLK1	100.0	100
TLK2	TLK2	100.0	100
TNIK	TNIK	100.0	100
TNK1	TNK1	88.0	100
TNK2	TNK2	100.0	100
TNNI3K	TNNI3K	79.0	100
NTRK1	TRKA	100.0	100
NTRK2	TRKB	100.0	100
NTRK3	TRKC	100.0	100
TRPM6	TRPM6	94.0	100
TSSK1B	TSSK1B	94.0	100
TSSK3	TSSK3	100.0	100
TTK	TTK	91.0	100
TXK	TXK	100.0	100
TYK2	TYK2(JH2domain-pseudokinase)	100.0	100
TYRO3	TYRO3	100.0	100
ULK1	ULK1	100.0	100
ULK2	ULK2	100.0	100
ULK3	ULK3	100.0	100
KDR	VEGFR2	97.0	100
PIK3C3	VPS34	100.0	100
VRK2	VRK2	100.0	100
WEE1	WEE1	97.0	100
WEE2	WEE2	100.0	100
WNK1	WNK1	100.0	100
WNK2	WNK2	100.0	100
WNK3	WNK3	100.0	100
WNK4	WNK4	100.0	100
STK32A	YANK1	76.0	100
STK32B	YANK2	100.0	100
STK32C	YANK3	100.0	100
YES1	YES	100.0	100
STK25	YSK1	81.0	100
MAP3K19	YSK4	89.0	100
MAP3K20	ZAK	100.0	100
ZAP70	ZAP70	100.0	100

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Selectivity data for probe SR-318 and control SR-321

PDSP data

SR-318

SR-321

DiscoverX KinomeScan data

SR-318

SR-321