Selectivity data for probe TP-008 and control Al11
Jump to control PDSP data
TP-008
Compound concentration: 10 µM| Receptor | HGNC target name | Inhibition [%] (Primary experimental value) | Ki [nM] (Secondary experimental value) | pKi |
|---|---|---|---|---|
| 5-HT1A | HTR1A | 22.86 | ||
| 5-HT1B | HTR1B | 19.51 | ||
| 5-HT1D | HTR1D | 5.53 | ||
| 5-HT1E | HTR1E | -5.81 | ||
| 5-HT2A | HTR2A | -0.87 | ||
| 5-HT2B | HTR2B | 70.48 | 1881.00 | 5.73 |
| 5-HT2C | HTR2C | 15.52 | ||
| 5-HT3 | HTR3A | -6.36 | ||
| 5-HT5A | HTR5A | 16.77 | ||
| 5-HT6 | HTR6 | -4.28 | ||
| 5-HT7A | HTR7 | 3.97 | ||
| D1 | DRD1 | 12.87 | ||
| D2 | DRD2 | -5.48 | ||
| D3 | DRD3 | 2.27 | ||
| D4 | DRD4 | 5.41 | ||
| D5 | DRD5 | -12.68 | ||
| SERT | SLC6A4 | 3.84 | ||
| NET | SLC6A2 | -16.56 | ||
| DAT | SLC6A3 | 87.59 | > 10000.00 | < 5.00 |
| MOR | OPRM1 | 13.66 | ||
| DOR | OPRD1 | -4.16 | ||
| KOR | OPRK1 | -0.98 | ||
| GABAA | 27.31 | |||
| H1 | HRH1 | 0.85 | ||
| H2 | HRH2 | 6.53 | ||
| H3 | HRH3 | 30.52 | ||
| H4 | HRH4 | 26.65 | ||
| Alpha1A | ADRA1A | -2.17 | ||
| Alpha1B | ADRA1B | 3.76 | ||
| Alpha2A | ADRA2A | -0.77 | ||
| Alpha2B | ADRA2B | 18.06 | ||
| Alpha2C | ADRA2C | -5.16 | ||
| Beta1 | ADRB1 | -17.89 | ||
| Beta2 | ADRB2 | 13.88 | ||
| M1 | CHRM1 | -3.81 | ||
| M2 | CHRM2 | 2.23 | ||
| M3 | CHRM3 | -7.48 | ||
| M4 | CHRM4 | -3.08 | ||
| M5 | CHRM5 | -5.69 | ||
| Beta3 | ADRB3 | 3.94 | ||
| GABAA/BZP | 31.78 | |||
| GABA/PBR | -8.98 | |||
| Alpha1D | ADRA1D | -12.85 | ||
| Sigma 2 | TMEM97 | -2.75 | ||
| Sigma 1 | SIGMAR1 | 50.00 | > 10000.00 | < 5.00 |
Al11
Compound concentration: 10 µM| Receptor | HGNC target name | Inhibition [%] (Primary experimental value) | Ki [nM] (Secondary experimental value) | pKi |
|---|---|---|---|---|
| 5-HT2C | HTR2C | 10.20 | ||
| 5-HT3 | HTR3A | 19.85 | ||
| 5-HT5A | HTR5A | -0.66 | ||
| Beta2 | ADRB2 | 16.70 | ||
| DOR | OPRD1 | 17.46 | ||
| H1 | HRH1 | -2.43 | ||
| H2 | HRH2 | -19.72 | ||
| H3 | HRH3 | -8.16 | ||
| M3 | CHRM3 | -5.28 | ||
| M4 | CHRM4 | 3.09 | ||
| M5 | CHRM5 | 1.56 | ||
| SERT | SLC6A4 | 14.28 | ||
| Sigma 1 | SIGMAR1 | 13.22 | ||
| 5-HT1A | HTR1A | 11.97 | ||
| 5-HT1B | HTR1B | -7.07 | ||
| 5-HT1D | HTR1D | -22.63 | ||
| 5-HT1E | HTR1E | -22.11 | ||
| 5-HT2A | HTR2A | 11.15 | ||
| 5-HT2B | HTR2B | 72.03 | 1591.74 average (n=2) | 5.81 |
| 5-HT6 | HTR6 | 14.14 | ||
| 5-HT7A | HTR7 | 12.06 | ||
| D1 | DRD1 | -2.08 | ||
| D2 | DRD2 | -1.99 | ||
| D3 | DRD3 | -17.02 | ||
| Alpha1A | ADRA1A | 0.25 | ||
| Alpha1B | ADRA1B | 5.45 | ||
| Alpha1D | ADRA1D | 2.71 | ||
| Alpha2A | ADRA2A | 3.10 | ||
| Alpha2B | ADRA2B | 17.31 | ||
| Alpha2C | ADRA2C | 17.90 | ||
| M1 | CHRM1 | -1.17 | ||
| M2 | CHRM2 | 14.42 | ||
| Sigma 2 | TMEM97 | 41.64 | ||
| D4 | DRD4 | -1.38 | ||
| D5 | DRD5 | 6.12 | ||
| DAT | SLC6A3 | -4.34 | ||
| H4 | HRH4 | -20.13 | ||
| KOR | OPRK1 | 13.51 | ||
| MOR | OPRM1 | 47.40 | ||
| NET | SLC6A2 | -13.54 | ||
| GABAA/BZP | 50.22 | 2746.00 | 5.56 | |
| GABAA | -14.29 | |||
| GABA/PBR | 27.09 | |||
| Beta1 | ADRB1 | 25.75 | ||
| Beta3 | ADRB3 | 9.94 |