Physicochemical properties of probe BAY-277 and control BAY-8805
| BAY-277 | |
|---|---|
| TPSA | 142 Å2 |
| Stability plasma 4 h, rat | 56 % |
| Stability plasma 4 h, human | 64 % |
| log D (pH 7.5) | 2.1 |
| Ligand-lipophilicity efficiency (LLE) (calc., based on DC50 HT1080) | 6.0 |
| BEI | 10.0 % |
| BAY-8805 | |
|---|---|
| TPSA | 125 Å2 |
| Stability plasma 4 h, rat | 100 % |
| Stability plasma 4 h, human | 100 % |
| log D (pH 7.5) | 2.1 |
Solubility
| BAY-277: |
aqueous solution pH 2: 344 mg/L,
aqueous solution pH 4: 253 mg/L,
aqueous solution pH 6.5: 175 mg/L
|
| BAY-8805: |
aqueous solution pH 2: 466 mg/L,
aqueous solution pH 4: 592 mg/L,
aqueous solution pH 6.5: 516 mg/L
|