Physicochemical properties of probe BAY-7081 and control BAY-7424
| BAY-7081 | |
|---|---|
| TPSA | 68 Å2 |
| Stability (pH1, 7, 10; 24h) | 1 |
| log D (pH 7.5) | 1.9 |
| Ligand-lipophilicity efficiency (LLE) (calc., based on hIC50) | 6.1 |
| BEI | 24.0 % |
| BAY-7424 | |
|---|---|
| TPSA | 68 Å2 |
| Stability (pH1, 8; 24h) | 1 |
| BEI | < 15 % |
| Ligand-lipophilicity efficiency (LLE) (calc., based on hIC50) | < 2.8 |
| log D (pH 7.5) | 1.9 |
Solubility
| BAY-7081: |
Aqueous pH 7 (crystaline material): > 500 mg/L
|
| BAY-7424: |
Aqueous pH 7 (partially crystaline): > 400 mg/L
|