Physicochemical properties of GSK046
| GSK046 | |
|---|---|
| Artificial Membrane Permeability (AMP) | 17 nm/s |
| Appearance | cream solid |
| Chrom log D pH 7.4 | 2.8 |
| C log P | 1.3 |
| DB2 ligand efficiency (LE) | 0.3 |
| Property Forecast Index (PFI) | 4.8 |
Solubility
| GSK046: |
FaSSIF (fasted state simulated intestinal fluid): 996 µg/mL,
Kinetic aqueous solubility measured with Chemiluminescent Nitrogen Detection (CLND): 91 µg/mL
|