Physicochemical properties of probe JNJ-79883960 and control JNJ-78832000
| JNJ-79883960 | |
|---|---|
| chrom log D (pH 7.4) | 2.1 |
| chrom log D (pH 2.6) | 2.0 |
| chrom log D (pH 10.5) | 1.9 |
| TPSA | 108.1 Å2 |
| EPSA | 90.0 Å2 |
| JNJ-78832000 | |
|---|---|
| chrom log D (pH 7.4) | 2.0 |
| chrom log D (pH 2.6) | 2.0 |
| chrom log D (pH 10.5) | 2.3 |
| TPSA | 95.2 Å2 |
| EPSA | 97.6 Å2 |
Solubility
| JNJ-79883960: |
Aqueous pH 2.0: 64.3 µM,
Aqueous pH 7.4: 68.4 µM
|
| JNJ-78832000: |
Aqueous pH 2.0: 8.4 µM,
Aqueous pH 7.4: 1.6 µM
|