In cells

Use at concentration of 0.8 µM.

Use the recommended concentration to avoid off-target toxicity and/or off-target activity. Using concentrations that are higher than recommended could lead to false positive or confounding results.

In vivo

A-485 was shown to be efficacious in the LuCaP-77 CR xenograft model with mice receiving a dose of 100 mkd, ip, BID x 21.