In cells

Use BAY-293 in the range of 20 nM to 1.1 µM depending on the assay type: SOS1 - KRAS(G12C) interaction (20 nM), active RAS HeLa (410 nM), pERK K-562 (180 nM), Proliferation K-562 (1.1 µM).

Use the recommended concentration to avoid off-target toxicity and/or off-target activity. Using concentrations that are higher than recommended could lead to false positive or confounding results.

In vivo

Not recommended for in vivo use due to low bioavailability.