In cells

Use at concentration of 100 nM.

We recommend to use the TRPA1 antagonist A-079 also available from SGC for control experiments.

Use the recommended concentration to avoid off-target toxicity and/or off-target activity. Using concentrations that are higher than recommended could lead to false positive or confounding results.

In vivo

BAY-390 shows a suitable pharmacokinetic profile for in vivo studies in rodents. It was tested in rats with 30 to 90 mg/kg PO twice a day for 10 days.