In cells

Use at concentration up to 1 µM.

Use the recommended concentration to avoid off-target toxicity and/or off-target activity. Using concentrations that are higher than recommended could lead to false positive or confounding results.

In vivo

Tested in rat with 1 mg/kg dose for i.v. and 5 mg/kg dose for p.o.. Active in murine ex vivo PK/PD model, mouse collagen induced arthritis model.