In cells

Use at a concentration up to 1 µM.

Use the recommended concentration to avoid off-target toxicity and/or off-target activity. Using concentrations that are higher than recommended could lead to false positive or confounding results.

In vivo

Use at a concentration up to 30 mg/kg; Significant glucosylceramide reduction in the plasma and brain of normal mice by oral administration; Significant glucosylceramide and glycosphingolipids reduction in Gaucher’s disease model mice.