Potency data for probe ABT-724 and control A-769
No in vitro potency data available.
In cell potency
| Target name | Target information | Species | Assay description | ABT-724 | A-769 | Publication of assay conditions |
|---|---|---|---|---|---|---|
| DRD4.2 | Membrane preparations expressing the human D4 variants | Homo sapiens | Radioligand assay using 3[H] A-369508 | Ki = 57.5 nM ± 8.000 nM (n=4) | PMID: 15087502 | |
| DRD4.4 | Membrane preparations expressing the human D4 variants | Homo sapiens | Radioligand assay (DRD4.4) | Ki = 63.6 nM ± 6.600 nM (n=4) | PMID: 15087502 | |
| DRD4.7 | Membrane preparations expressing the human D4 variants | Homo sapiens | Radioligand assay (DRD4.7) | Ki = 46.8 nM ± 4.800 nM (n=4) | PMID: 15087502 | |
| DRD4 | HEX293 cells stably expressing cloned human DRD4.4 and G protein chimera Gαqo5 | Homo sapiens | Cellular FLIPR (fluorometric imaging plate reader) assay | EC50 = 12.4 nM ± 1.000 nM | IC50 > 10 µM | PMID: 15239663 |