Potency data for probe BAY-678 and control BAY-677
In vitro potency
| Target name | Target information | Species | Assay description | BAY-678 | BAY-677 | Publication of assay conditions |
|---|---|---|---|---|---|---|
| ELANE | Human neutrophil elastase purified from blood neutrophils | Homo sapiens | Bicochemical assay: Hydrolysis of the fluorogenic peptide substrate MeOSuc-AAPV-AMC | IC50 = 20 nM | IC50 > 2000 nM | PMID: 26083237 |
| ELANE | Homo sapiens | Determined from Dixon plot | Ki = 15 nM | PMID: 26083237 |
No in cell potency data available.