In cells

Use at a concentration up to 1 µM.

We recommend to use together with the ELANE inhibitor BI-5524 also available from SGC for control experiments.

Use the recommended concentration to avoid off-target toxicity and/or off-target activity. Using concentrations that are higher than recommended could lead to false positive or confounding results.

In vivo

Tested in mice with a oral dose of 1 - 60 mg/kg on different chronic in vivo models.