Potency data for probe BAY-885 and control BAY-693
No in vitro potency data available.
In cell potency
| Target name | Target information | Species | Assay description | BAY-885 | BAY-693 | Publication of assay conditions |
|---|---|---|---|---|---|---|
| SLC2A1, MAPK7 | Homo sapiens | Cellular mechanistic assay: Inhibition of glucose uptake by Hela-MaTu cells | IC50 = 35 nM | IC50 = 6.4 µM | PMID: 30563338 | |
| MAPK7 | Homo sapiens | Cellular luciferase reporter assay using the SN12C-MEF2-luc cell line and ONE-Glo | IC50 = 115 nM | IC50 = 11 µM | PMID: 30563338 | |
| Homo sapiens | Proliferation assay: SN12C (renal cell carcinoma): Cell viability was determined with a CellTiter-Glo® luminescent assay | IC50 > 30 µM | ||||
| Homo sapiens | Proliferation assay: SNU-449 (hepatocellular carcinoma): Cell viability was determined with a CellTiter-Glo® luminescent assay | IC50 > 30 µM | IC50 = 19.5 µM | |||
| Homo sapiens | Proliferation assay: BT-474 (breast cancer): Cell viability was determined with a CellTiter-Glo® luminescent assay | IC50 > 30 µM | IC50 = 27.6 µM | |||
| Homo sapiens | Proliferation assay: SK-BR-3 (breast cancer): Cell viability was determined with a CellTiter-Glo® luminescent assay | IC50 > 30 µM | IC50 = 22.4 µM | |||
| Homo sapiens | Proliferation assay: SN12C (renal cell carcinoma): Cell viability was determined with a CellTiter-Glo® luminescent assay | IC50 = 29.3 µM |