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Selectivity data for probe BAY-885 and control BAY-693


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BAY-885


Compound concentration: 10 µM
Receptor HGNC target name Inhibition [%] (Primary experimental value) Ki [nM] (Secondary experimental value) pKi
5-HT6 HTR6 -4.69
5-HT1B HTR1B 14.93
5-HT1E HTR1E 14.21
5-HT2B HTR2B 3.56
Alpha1A ADRA1A 1.11
Alpha1B ADRA1B 16.40
H1 HRH1 14.59
H2 HRH2 31.16
D3 DRD3 7.59
D4 DRD4 12.72
D5 DRD5 4.63
M1 SLC6A3 3.17
M2 CHRM2 -0.56
M3 CHRM3 27.05
M4 CHRM4 -13.08
Sigma 1 SIGMAR1 72.36 2502.07 5.60
5-HT2C HTR2C -4.77
Alpha1D ADRA1D -10.29
Alpha2A ADRA2A -3.41
Alpha2B ADRA2B -8.47
Alpha2C ADRA2C -2.34
Beta2 ADRB2 -4.21
D2 DRD2 -10.41
DOR OPRD1 0.94
KOR OPRK1 9.37
MOR OPRM1 13.19
SERT SLC6A4 32.36
H4 HRH4 -1.34
5-HT1D HTR1D 16.04
5-HT7A HTR7 -9.57
Beta1 ADRB1 12.61
Beta3 ADRB3 -19.67
GABAA/BZP 0.38
D1 DRD1 -16.49
H3 HRH3 36.90
M5 CHRM5 2.02
NET SLC6A2 -17.25
GABA/PBR -10.37
5-HT1A HTR1A 7.38
GABAA 21.80
5-HT2A HTR2A 4.33
5-HT3 HTR3A 5.22
5-HT5A HTR5A -1.47
Sigma 2 TMEM97 30.95

BAY-693


Compound concentration: 10 µM
Receptor HGNC target name Inhibition [%] (Primary experimental value) Ki [nM] (Secondary experimental value) pKi
M1 SLC6A3 2.76
5-HT2A HTR2A 4.68
5-HT3 HTR3A 6.25
5-HT5A HTR5A -3.74
Sigma 2 TMEM97 51.41 4903.43 5.31
5-HT1A HTR1A -3.88
GABAA 15.01
5-HT1D HTR1D -2.17
5-HT7A HTR7 -0.78
Beta1 ADRB1 17.92
Beta3 ADRB3 -12.58
GABAA/BZP -1.64
D1 DRD1 2.66
H3 HRH3 38.43
M5 CHRM5 -3.81
NET SLC6A2 24.64
GABA/PBR -4.32
H4 HRH4 -5.28
5-HT1B HTR1B 14.56
5-HT1E HTR1E -9.94
5-HT2B HTR2B -1.28
Alpha1A ADRA1A -9.85
Alpha1B ADRA1B 20.25
H1 HRH1 4.99
H2 HRH2 23.59
D3 DRD3 -8.88
D4 DRD4 1.98
D5 DRD5 12.39
M2 CHRM2 -1.00
M3 CHRM3 18.58
M4 CHRM4 -2.04
Sigma 1 SIGMAR1 72.68 2368.65 5.63
5-HT2C HTR2C -14.55
Alpha1D ADRA1D 5.29
Alpha2A ADRA2A -6.02
Alpha2B ADRA2B -12.56
Alpha2C ADRA2C -6.01
Beta2 ADRB2 -5.65
D2 DRD2 2.97
DOR OPRD1 4.34
KOR OPRK1 21.16
MOR OPRM1 -1.66
SERT SLC6A4 11.31
5-HT6 HTR6 -1.38

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Primary results are shown as '% Ctrl', i.e. the negative control (DMSO) is equal 100% control and the positive control (control compound) is equal 0% control. For compounds showing less than 50% of control in the primary screening assay, a Kd will be determined. Note: It cannot be excluded that 0 % control values are due to assay artefacts.
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BAY-885


HGNC target name DiscoverX gene symbol of kinase % Control Compound Concentration [nM] Kd [nM]
AAK1 AAK1 100.0 1000
ABL1 ABL1-phosphorylated 86.0 1000
ABL2 ABL2 100.0 1000
ACVR1 ACVR1 100.0 1000
ACVR1B ACVR1B 79.0 1000
ACVR2A ACVR2A 100.0 1000
ACVR2B ACVR2B 100.0 1000
ACVRL1 ACVRL1 94.0 1000
COQ8A ADCK3 100.0 1000
COQ8B ADCK4 100.0 1000
AKT1 AKT1 100.0 1000
AKT2 AKT2 100.0 1000
AKT3 AKT3 93.0 1000
ALK ALK(L1196M) 100.0 1000
PRKAA1 AMPK-alpha1 87.0 1000
PRKAA2 AMPK-alpha2 100.0 1000
ANKK1 ANKK1 98.0 1000
NUAK1 ARK5 100.0 1000
MAP3K5 ASK1 92.0 1000
MAP3K6 ASK2 100.0 1000
AURKA AURKA 100.0 1000
AURKB AURKB 90.0 1000
AURKC AURKC 67.0 1000
AXL AXL 78.0 1000
BMP2K BIKE 97.0 1000
BLK BLK 91.0 1000
BMPR1A BMPR1A 79.0 1000
BMPR1B BMPR1B 100.0 1000
BMPR2 BMPR2 100.0 1000
BMX BMX 100.0 1000
BRAF BRAF(V600E) 100.0 1000
PTK6 BRK 100.0 1000
BRSK1 BRSK1 100.0 1000
BRSK2 BRSK2 100.0 1000
BTK BTK 100.0 1000
BUB1 BUB1 93.0 1000
CAMK1 CAMK1 100.0 1000
PNCK CAMK1B 100.0 1000
CAMK1D CAMK1D 100.0 1000
CAMK1G CAMK1G 100.0 1000
CAMK2A CAMK2A 69.0 1000
CAMK2B CAMK2B 100.0 1000
CAMK2D CAMK2D 100.0 1000
CAMK2G CAMK2G 100.0 1000
CAMK4 CAMK4 94.0 1000
CAMKK1 CAMKK1 100.0 1000
CAMKK2 CAMKK2 100.0 1000
CASK CASK 89.0 1000
CDK11B CDC2L1 82.0 1000
CDK11A CDC2L2 61.0 1000
CDK13 CDC2L5 62.0 1000
CDK19 CDK11 79.0 1000
CDK2 CDK2 100.0 1000
CDK3 CDK3 100.0 1000
CDK4 CDK4-cyclinD3 100.0 1000
CDK5 CDK5 87.0 1000
CDK7 CDK7 89.0 1000
CDK8 CDK8 100.0 1000
CDK9 CDK9 100.0 1000
CDKL1 CDKL1 94.0 1000
CDKL2 CDKL2 100.0 1000
CDKL3 CDKL3 92.0 1000
CDKL5 CDKL5 93.0 1000
CHEK1 CHEK1 100.0 1000
CHEK2 CHEK2 100.0 1000
CIT CIT 100.0 1000
CLK1 CLK1 100.0 1000
CLK2 CLK2 100.0 1000
CLK3 CLK3 100.0 1000
CLK4 CLK4 98.0 1000
CSF1R CSF1R-autoinhibited 92.0 1000
CSK CSK 100.0 1000
CSNK1A1 CSNK1A1 91.0 1000
CSNK1A1L CSNK1A1L 100.0 1000
CSNK1D CSNK1D 100.0 1000
CSNK1E CSNK1E 100.0 1000
CSNK1G1 CSNK1G1 100.0 1000
CSNK1G2 CSNK1G2 100.0 1000
CSNK1G3 CSNK1G3 100.0 1000
CSNK2A1 CSNK2A1 100.0 1000
CSNK2A2 CSNK2A2 93.0 1000
MATK CTK 100.0 1000
DAPK1 DAPK1 100.0 1000
DAPK2 DAPK2 90.0 1000
DAPK3 DAPK3 91.0 1000
DCLK1 DCAMKL1 85.0 1000
DCLK2 DCAMKL2 100.0 1000
DCLK3 DCAMKL3 91.0 1000
DDR1 DDR1 100.0 1000
DDR2 DDR2 100.0 1000
MAP3K12 DLK 100.0 1000
DMPK DMPK 89.0 1000
CDC42BPG DMPK2 100.0 1000
STK17A DRAK1 92.0 1000
STK17B DRAK2 86.0 1000
DYRK1A DYRK1A 100.0 1000
DYRK1B DYRK1B 54.0 1000
DYRK2 DYRK2 100.0 1000
EGFR EGFR(T790M) 84.0 1000
EIF2AK1 EIF2AK1 100.0 1000
EPHA1 EPHA1 95.0 1000
EPHA2 EPHA2 100.0 1000
EPHA3 EPHA3 100.0 1000
EPHA4 EPHA4 100.0 1000
EPHA5 EPHA5 91.0 1000
EPHA6 EPHA6 100.0 1000
EPHA7 EPHA7 100.0 1000
EPHA8 EPHA8 100.0 1000
EPHB1 EPHB1 100.0 1000
EPHB2 EPHB2 78.0 1000
EPHB3 EPHB3 100.0 1000
EPHB4 EPHB4 100.0 1000
EPHB6 EPHB6 18.0 1000
ERBB2 ERBB2 100.0 1000
ERBB3 ERBB3 84.0 1000
ERBB4 ERBB4 79.0 1000
MAPK3 ERK1 100.0 1000
MAPK1 ERK2 94.0 1000
MAPK6 ERK3 100.0 1000
MAPK4 ERK4 100.0 1000
MAPK7 ERK5 0.1 1000
MAPK15 ERK8 100.0 1000
ERN1 ERN1 99.0 1000
PTK2 FAK 100.0 1000
FER FER 100.0 1000
FES FES 100.0 1000
FGFR1 FGFR1 100.0 1000
FGFR2 FGFR2 100.0 1000
FGFR3 FGFR3(G697C) 100.0 1000
FGFR4 FGFR4 100.0 1000
FGR FGR 100.0 1000
FLT1 FLT1 76.0 1000
FLT3 FLT3-autoinhibited 100.0 1000
FLT4 FLT4 100.0 1000
FRK FRK 100.0 1000
FYN FYN 100.0 1000
GAK GAK 100.0 1000
EIF2AK4 GCN2(Kin.Dom.2,S808G) 99.0 1000
GRK1 GRK1 96.0 1000
GRK2 GRK2 100.0 1000
GRK3 GRK3 89.0 1000
GRK4 GRK4 100.0 1000
GRK7 GRK7 87.0 1000
GSK3A GSK3A 100.0 1000
GSK3B GSK3B 100.0 1000
HASPIN HASPIN 100.0 1000
HCK HCK 95.0 1000
HIPK1 HIPK1 99.0 1000
HIPK2 HIPK2 100.0 1000
HIPK3 HIPK3 100.0 1000
HIPK4 HIPK4 100.0 1000
MAP4K1 HPK1 88.0 1000
HUNK HUNK 95.0 1000
CILK1 ICK 100.0 1000
IGF1R IGF1R 100.0 1000
CHUK IKK-alpha 100.0 1000
IKBKB IKK-beta 100.0 1000
IKBKE IKK-epsilon 98.0 1000
INSR INSR 88.0 1000
INSRR INSRR 100.0 1000
IRAK1 IRAK1 100.0 1000
IRAK3 IRAK3 100.0 1000
IRAK4 IRAK4 90.0 1000
ITK ITK 100.0 1000
JAK1 JAK1(JH2domain-pseudokinase) 90.0 1000
JAK2 JAK2(JH1domain-catalytic) 83.0 1000
JAK3 JAK3(JH1domain-catalytic) 100.0 1000
MAPK8 JNK1 97.0 1000
MAPK9 JNK2 100.0 1000
MAPK10 JNK3 100.0 1000
KIT KIT-autoinhibited 85.0 1000
LATS1 LATS1 81.0 1000
LATS2 LATS2 100.0 1000
LCK LCK 100.0 1000
LIMK1 LIMK1 100.0 1000
LIMK2 LIMK2 100.0 1000
STK11 LKB1 100.0 1000
STK10 LOK 52.0 1000
LRRK2 LRRK2(G2019S) 100.0 1000
LTK LTK 49.0 1000
LYN LYN 75.0 1000
MAP3K13 LZK 100.0 1000
MAK MAK 100.0 1000
MAP3K1 MAP3K1 100.0 1000
MAP3K15 MAP3K15 95.0 1000
MAP3K2 MAP3K2 100.0 1000
MAP3K3 MAP3K3 94.0 1000
MAP3K4 MAP3K4 95.0 1000
MAP4K2 MAP4K2 82.0 1000
MAP4K3 MAP4K3 100.0 1000
MAP4K4 MAP4K4 100.0 1000
MAP4K5 MAP4K5 99.0 1000
MAPKAPK2 MAPKAPK2 100.0 1000
MAPKAPK5 MAPKAPK5 100.0 1000
MARK1 MARK1 100.0 1000
MARK2 MARK2 100.0 1000
MARK3 MARK3 93.0 1000
MARK4 MARK4 100.0 1000
MAST1 MAST1 100.0 1000
MAP2K1 MEK1 95.0 1000
MAP2K2 MEK2 100.0 1000
MAP2K3 MEK3 94.0 1000
MAP2K4 MEK4 100.0 1000
MAP2K5 MEK5 86.0 1000
MAP2K6 MEK6 88.0 1000
MELK MELK 85.0 1000
MERTK MERTK 75.0 1000
MET MET(Y1235D) 73.0 1000
MINK1 MINK 85.0 1000
MAP2K7 MKK7 100.0 1000
MKNK1 MKNK1 100.0 1000
MKNK2 MKNK2 100.0 1000
MYLK3 MLCK 82.0 1000
MAP3K9 MLK1 100.0 1000
MAP3K10 MLK2 100.0 1000
MAP3K11 MLK3 100.0 1000
CDC42BPA MRCKA 100.0 1000
CDC42BPB MRCKB 100.0 1000
STK4 MST1 84.0 1000
MST1R MST1R 90.0 1000
STK3 MST2 82.0 1000
STK24 MST3 100.0 1000
STK26 MST4 98.0 1000
MTOR MTOR 78.0 1000
MUSK MUSK 100.0 1000
MYLK MYLK 88.0 1000
MYLK2 MYLK2 85.0 1000
MYLK4 MYLK4 100.0 1000
MYO3A MYO3A 100.0 1000
MYO3B MYO3B 73.0 1000
STK38 NDR1 80.0 1000
STK38L NDR2 100.0 1000
NEK1 NEK1 85.0 1000
NEK10 NEK10 100.0 1000
NEK11 NEK11 100.0 1000
NEK2 NEK2 100.0 1000
NEK3 NEK3 97.0 1000
NEK4 NEK4 100.0 1000
NEK5 NEK5 100.0 1000
NEK6 NEK6 92.0 1000
NEK7 NEK7 100.0 1000
NEK9 NEK9 100.0 1000
MAP3K14 NIK 100.0 1000
NIM1K NIM1 100.0 1000
NLK NLK 100.0 1000
OXSR1 OSR1 100.0 1000
MAPK14 p38-alpha 99.0 1000
MAPK11 p38-beta 98.0 1000
MAPK13 p38-delta 100.0 1000
MAPK12 p38-gamma 83.0 1000
PAK1 PAK1 93.0 1000
PAK2 PAK2 100.0 1000
PAK3 PAK3 88.0 1000
PAK4 PAK4 91.0 1000
PAK6 PAK6 100.0 1000
PAK5 PAK7 100.0 1000
CDK16 PCTK1 100.0 1000
CDK17 PCTK2 93.0 1000
CDK18 PCTK3 100.0 1000
PDGFRA PDGFRA 100.0 1000
PDGFRB PDGFRB 95.0 1000
PDPK1 PDPK1 85.0 1000
CDPK1 PFCDPK1(P.falciparum) 100.0 1000
PK5 PFPK5(P.falciparum) 100.0 1000
CDK15 PFTAIRE2 100.0 1000
CDK14 PFTK1 100.0 1000
PHKG1 PHKG1 100.0 1000
PHKG2 PHKG2 100.0 1000
PIK3C2B PIK3C2B 98.0 1000
PIK3C2G PIK3C2G 100.0 1000
PIK3CA PIK3CA(Q546K) 100.0 1000
PIK3CB PIK3CB 100.0 1000
PIK3CD PIK3CD 86.0 1000
PIK3CG PIK3CG 95.0 1000
PI4KB PIK4CB 96.0 1000
PIKFYVE PIKFYVE 98.0 1000
PIM1 PIM1 90.0 1000
PIM2 PIM2 100.0 1000
PIM3 PIM3 100.0 1000
PIP5K1A PIP5K1A 64.0 1000
PIP5K1C PIP5K1C 100.0 1000
PIP4K2B PIP5K2B 79.0 1000
PIP4K2C PIP5K2C 100.0 1000
PRKACA PKAC-alpha 100.0 1000
PRKACB PKAC-beta 91.0 1000
PKMYT1 PKMYT1 100.0 1000
PKN1 PKN1 100.0 1000
PKN2 PKN2 100.0 1000
PKNB PKNB(M.tuberculosis) 97.0 1000
PLK1 PLK1 93.0 1000
PLK2 PLK2 93.0 1000
PLK3 PLK3 100.0 1000
PLK4 PLK4 83.0 1000
PRKCD PRKCD 100.0 1000
PRKCE PRKCE 100.0 1000
PRKCH PRKCH 86.0 1000
PRKCI PRKCI 77.0 1000
PRKCQ PRKCQ 91.0 1000
PRKD1 PRKD1 85.0 1000
PRKD2 PRKD2 100.0 1000
PRKD3 PRKD3 100.0 1000
PRKG1 PRKG1 83.0 1000
PRKG2 PRKG2 77.0 1000
EIF2AK2 PRKR 85.0 1000
PRKX PRKX 100.0 1000
PRPF4B PRP4 100.0 1000
PTK2B PYK2 100.0 1000
SIK3 QSK 100.0 1000
RAF1 RAF1 75.0 1000
RET RET(V804M) 100.0 1000
RIOK1 RIOK1 100.0 1000
RIOK2 RIOK2 100.0 1000
RIOK3 RIOK3 97.0 1000
RIPK1 RIPK1 100.0 1000
RIPK2 RIPK2 100.0 1000
RIPK4 RIPK4 100.0 1000
DSTYK RIPK5 100.0 1000
ROCK1 ROCK1 100.0 1000
ROCK2 ROCK2 100.0 1000
ROS1 ROS1 100.0 1000
RPS6KA4 RPS6KA4(Kin.Dom.2-C-terminal) 100.0 1000
RPS6KA5 RPS6KA5(Kin.Dom.2-C-terminal) 96.0 1000
RPS6KA1 RSK1(Kin.Dom.2-C-terminal) 100.0 1000
RPS6KA3 RSK2(Kin.Dom.2-C-terminal) 80.0 1000
RPS6KA2 RSK3(Kin.Dom.2-C-terminal) 100.0 1000
RPS6KA6 RSK4(Kin.Dom.2-C-terminal) 100.0 1000
RPS6KB1 S6K1 90.0 1000
SBK1 SBK1 100.0 1000
SGK1 SGK 100.0 1000
SBK3 SgK110 72.0 1000
SGK2 SGK2 92.0 1000
SGK3 SGK3 100.0 1000
SIK1 SIK 92.0 1000
SIK2 SIK2 100.0 1000
SLK SLK 96.0 1000
NUAK2 SNARK 90.0 1000
SNRK SNRK 87.0 1000
SRC SRC 100.0 1000
SRMS SRMS 100.0 1000
SRPK1 SRPK1 88.0 1000
SRPK2 SRPK2 78.0 1000
SRPK3 SRPK3 100.0 1000
STK16 STK16 100.0 1000
STK33 STK33 99.0 1000
STK35 STK35 100.0 1000
STK36 STK36 75.0 1000
STK39 STK39 81.0 1000
SYK SYK 100.0 1000
MAP3K7 TAK1 100.0 1000
TAOK1 TAOK1 100.0 1000
TAOK2 TAOK2 100.0 1000
TAOK3 TAOK3 100.0 1000
TBK1 TBK1 61.0 1000
TEC TEC 100.0 1000
TESK1 TESK1 96.0 1000
TGFBR1 TGFBR1 90.0 1000
TGFBR2 TGFBR2 88.0 1000
TIE1 TIE1 80.0 1000
TEK TIE2 74.0 1000
TLK1 TLK1 100.0 1000
TLK2 TLK2 89.0 1000
TNIK TNIK 100.0 1000
TNK1 TNK1 100.0 1000
TNK2 TNK2 100.0 1000
TNNI3K TNNI3K 100.0 1000
NTRK1 TRKA 100.0 1000
NTRK2 TRKB 100.0 1000
NTRK3 TRKC 100.0 1000
TRPM6 TRPM6 100.0 1000
TSSK1B TSSK1B 100.0 1000
TSSK3 TSSK3 68.0 1000
TTK TTK 100.0 1000
TXK TXK 88.0 1000
TYK2 TYK2(JH2domain-pseudokinase) 100.0 1000
TYRO3 TYRO3 100.0 1000
ULK1 ULK1 100.0 1000
ULK2 ULK2 100.0 1000
ULK3 ULK3 100.0 1000
KDR VEGFR2 100.0 1000
PIK3C3 VPS34 100.0 1000
VRK2 VRK2 100.0 1000
WEE1 WEE1 96.0 1000
WEE2 WEE2 100.0 1000
WNK1 WNK1 100.0 1000
WNK2 WNK2 100.0 1000
WNK3 WNK3 100.0 1000
WNK4 WNK4 99.0 1000
STK32A YANK1 94.0 1000
STK32B YANK2 87.0 1000
STK32C YANK3 100.0 1000
YES1 YES 100.0 1000
STK25 YSK1 92.0 1000
MAP3K19 YSK4 83.0 1000
MAP3K20 ZAK 98.0 1000
ZAP70 ZAP70 100.0 1000

BAY-693


HGNC target name DiscoverX gene symbol of kinase % Control Compound Concentration [nM] Kd [nM]
AAK1 AAK1 100.0 1000
ABL1 ABL1-phosphorylated 92.0 1000
ABL2 ABL2 93.0 1000
ACVR1 ACVR1 100.0 1000
ACVR1B ACVR1B 86.0 1000
ACVR2A ACVR2A 100.0 1000
ACVR2B ACVR2B 100.0 1000
ACVRL1 ACVRL1 91.0 1000
COQ8A ADCK3 100.0 1000
COQ8B ADCK4 93.0 1000
AKT1 AKT1 100.0 1000
AKT2 AKT2 100.0 1000
AKT3 AKT3 95.0 1000
ALK ALK(L1196M) 98.0 1000
PRKAA1 AMPK-alpha1 98.0 1000
PRKAA2 AMPK-alpha2 100.0 1000
ANKK1 ANKK1 81.0 1000
NUAK1 ARK5 95.0 1000
MAP3K5 ASK1 99.0 1000
MAP3K6 ASK2 100.0 1000
AURKA AURKA 99.0 1000
AURKB AURKB 88.0 1000
AURKC AURKC 100.0 1000
AXL AXL 100.0 1000
BMP2K BIKE 100.0 1000
BLK BLK 97.0 1000
BMPR1A BMPR1A 80.0 1000
BMPR1B BMPR1B 93.0 1000
BMPR2 BMPR2 100.0 1000
BMX BMX 100.0 1000
BRAF BRAF(V600E) 100.0 1000
PTK6 BRK 100.0 1000
BRSK1 BRSK1 100.0 1000
BRSK2 BRSK2 100.0 1000
BTK BTK 87.0 1000
BUB1 BUB1 96.0 1000
CAMK1 CAMK1 100.0 1000
PNCK CAMK1B 100.0 1000
CAMK1D CAMK1D 100.0 1000
CAMK1G CAMK1G 100.0 1000
CAMK2A CAMK2A 93.0 1000
CAMK2B CAMK2B 100.0 1000
CAMK2D CAMK2D 100.0 1000
CAMK2G CAMK2G 100.0 1000
CAMK4 CAMK4 95.0 1000
CAMKK1 CAMKK1 100.0 1000
CAMKK2 CAMKK2 100.0 1000
CASK CASK 87.0 1000
CDK11B CDC2L1 87.0 1000
CDK11A CDC2L2 100.0 1000
CDK13 CDC2L5 88.0 1000
CDK19 CDK11 86.0 1000
CDK2 CDK2 87.0 1000
CDK3 CDK3 100.0 1000
CDK4 CDK4-cyclinD3 100.0 1000
CDK5 CDK5 88.0 1000
CDK7 CDK7 100.0 1000
CDK8 CDK8 100.0 1000
CDK9 CDK9 79.0 1000
CDKL1 CDKL1 89.0 1000
CDKL2 CDKL2 100.0 1000
CDKL3 CDKL3 92.0 1000
CDKL5 CDKL5 89.0 1000
CHEK1 CHEK1 100.0 1000
CHEK2 CHEK2 100.0 1000
CIT CIT 100.0 1000
CLK1 CLK1 100.0 1000
CLK2 CLK2 100.0 1000
CLK3 CLK3 94.0 1000
CLK4 CLK4 97.0 1000
CSF1R CSF1R-autoinhibited 94.0 1000
CSK CSK 100.0 1000
CSNK1A1 CSNK1A1 100.0 1000
CSNK1A1L CSNK1A1L 100.0 1000
CSNK1D CSNK1D 83.0 1000
CSNK1E CSNK1E 100.0 1000
CSNK1G1 CSNK1G1 100.0 1000
CSNK1G2 CSNK1G2 93.0 1000
CSNK1G3 CSNK1G3 100.0 1000
CSNK2A1 CSNK2A1 99.0 1000
CSNK2A2 CSNK2A2 85.0 1000
MATK CTK 100.0 1000
DAPK1 DAPK1 95.0 1000
DAPK2 DAPK2 100.0 1000
DAPK3 DAPK3 100.0 1000
DCLK1 DCAMKL1 85.0 1000
DCLK2 DCAMKL2 100.0 1000
DCLK3 DCAMKL3 98.0 1000
DDR1 DDR1 100.0 1000
DDR2 DDR2 92.0 1000
MAP3K12 DLK 100.0 1000
DMPK DMPK 100.0 1000
CDC42BPG DMPK2 100.0 1000
STK17A DRAK1 100.0 1000
STK17B DRAK2 99.0 1000
DYRK1A DYRK1A 100.0 1000
DYRK1B DYRK1B 61.0 1000
DYRK2 DYRK2 100.0 1000
EGFR EGFR(T790M) 100.0 1000
EIF2AK1 EIF2AK1 85.0 1000
EPHA1 EPHA1 100.0 1000
EPHA2 EPHA2 100.0 1000
EPHA3 EPHA3 92.0 1000
EPHA4 EPHA4 100.0 1000
EPHA5 EPHA5 99.0 1000
EPHA6 EPHA6 95.0 1000
EPHA7 EPHA7 92.0 1000
EPHA8 EPHA8 98.0 1000
EPHB1 EPHB1 95.0 1000
EPHB2 EPHB2 100.0 1000
EPHB3 EPHB3 100.0 1000
EPHB4 EPHB4 92.0 1000
EPHB6 EPHB6 100.0 1000
ERBB2 ERBB2 100.0 1000
ERBB3 ERBB3 88.0 1000
ERBB4 ERBB4 100.0 1000
MAPK3 ERK1 98.0 1000
MAPK1 ERK2 98.0 1000
MAPK6 ERK3 100.0 1000
MAPK4 ERK4 91.0 1000
MAPK7 ERK5 22.0 1000
MAPK15 ERK8 100.0 1000
ERN1 ERN1 100.0 1000
PTK2 FAK 91.0 1000
FER FER 99.0 1000
FES FES 96.0 1000
FGFR1 FGFR1 100.0 1000
FGFR2 FGFR2 100.0 1000
FGFR3 FGFR3(G697C) 100.0 1000
FGFR4 FGFR4 100.0 1000
FGR FGR 100.0 1000
FLT1 FLT1 88.0 1000
FLT3 FLT3-autoinhibited 83.0 1000
FLT4 FLT4 75.0 1000
FRK FRK 95.0 1000
FYN FYN 96.0 1000
GAK GAK 100.0 1000
EIF2AK4 GCN2(Kin.Dom.2,S808G) 90.0 1000
GRK1 GRK1 100.0 1000
GRK2 GRK2 92.0 1000
GRK3 GRK3 93.0 1000
GRK4 GRK4 96.0 1000
GRK7 GRK7 81.0 1000
GSK3A GSK3A 85.0 1000
GSK3B GSK3B 100.0 1000
HASPIN HASPIN 100.0 1000
HCK HCK 95.0 1000
HIPK1 HIPK1 100.0 1000
HIPK2 HIPK2 93.0 1000
HIPK3 HIPK3 96.0 1000
HIPK4 HIPK4 88.0 1000
MAP4K1 HPK1 96.0 1000
HUNK HUNK 100.0 1000
CILK1 ICK 84.0 1000
IGF1R IGF1R 91.0 1000
CHUK IKK-alpha 84.0 1000
IKBKB IKK-beta 78.0 1000
IKBKE IKK-epsilon 97.0 1000
INSR INSR 93.0 1000
INSRR INSRR 100.0 1000
IRAK1 IRAK1 100.0 1000
IRAK3 IRAK3 99.0 1000
IRAK4 IRAK4 90.0 1000
ITK ITK 89.0 1000
JAK1 JAK1(JH2domain-pseudokinase) 90.0 1000
JAK2 JAK2(JH1domain-catalytic) 99.0 1000
JAK3 JAK3(JH1domain-catalytic) 100.0 1000
MAPK8 JNK1 98.0 1000
MAPK9 JNK2 100.0 1000
MAPK10 JNK3 100.0 1000
KIT KIT-autoinhibited 76.0 1000
LATS1 LATS1 78.0 1000
LATS2 LATS2 100.0 1000
LCK LCK 100.0 1000
LIMK1 LIMK1 93.0 1000
LIMK2 LIMK2 95.0 1000
STK11 LKB1 100.0 1000
STK10 LOK 96.0 1000
LRRK2 LRRK2(G2019S) 100.0 1000
LTK LTK 86.0 1000
LYN LYN 100.0 1000
MAP3K13 LZK 100.0 1000
MAK MAK 99.0 1000
MAP3K1 MAP3K1 82.0 1000
MAP3K15 MAP3K15 92.0 1000
MAP3K2 MAP3K2 100.0 1000
MAP3K3 MAP3K3 92.0 1000
MAP3K4 MAP3K4 100.0 1000
MAP4K2 MAP4K2 80.0 1000
MAP4K3 MAP4K3 100.0 1000
MAP4K4 MAP4K4 100.0 1000
MAP4K5 MAP4K5 100.0 1000
MAPKAPK2 MAPKAPK2 100.0 1000
MAPKAPK5 MAPKAPK5 94.0 1000
MARK1 MARK1 100.0 1000
MARK2 MARK2 100.0 1000
MARK3 MARK3 89.0 1000
MARK4 MARK4 100.0 1000
MAST1 MAST1 100.0 1000
MAP2K1 MEK1 85.0 1000
MAP2K2 MEK2 100.0 1000
MAP2K3 MEK3 98.0 1000
MAP2K4 MEK4 100.0 1000
MAP2K5 MEK5 83.0 1000
MAP2K6 MEK6 97.0 1000
MELK MELK 93.0 1000
MERTK MERTK 87.0 1000
MET MET(Y1235D) 98.0 1000
MINK1 MINK 93.0 1000
MAP2K7 MKK7 86.0 1000
MKNK1 MKNK1 100.0 1000
MKNK2 MKNK2 100.0 1000
MYLK3 MLCK 100.0 1000
MAP3K9 MLK1 97.0 1000
MAP3K10 MLK2 100.0 1000
MAP3K11 MLK3 100.0 1000
CDC42BPA MRCKA 99.0 1000
CDC42BPB MRCKB 100.0 1000
STK4 MST1 85.0 1000
MST1R MST1R 82.0 1000
STK3 MST2 79.0 1000
STK24 MST3 97.0 1000
STK26 MST4 100.0 1000
MTOR MTOR 78.0 1000
MUSK MUSK 100.0 1000
MYLK MYLK 100.0 1000
MYLK2 MYLK2 87.0 1000
MYLK4 MYLK4 100.0 1000
MYO3A MYO3A 100.0 1000
MYO3B MYO3B 71.0 1000
STK38 NDR1 94.0 1000
STK38L NDR2 100.0 1000
NEK1 NEK1 97.0 1000
NEK10 NEK10 100.0 1000
NEK11 NEK11 100.0 1000
NEK2 NEK2 100.0 1000
NEK3 NEK3 89.0 1000
NEK4 NEK4 100.0 1000
NEK5 NEK5 100.0 1000
NEK6 NEK6 100.0 1000
NEK7 NEK7 100.0 1000
NEK9 NEK9 94.0 1000
MAP3K14 NIK 100.0 1000
NIM1K NIM1 89.0 1000
NLK NLK 100.0 1000
OXSR1 OSR1 49.0 1000
MAPK14 p38-alpha 100.0 1000
MAPK11 p38-beta 100.0 1000
MAPK13 p38-delta 100.0 1000
MAPK12 p38-gamma 100.0 1000
PAK1 PAK1 100.0 1000
PAK2 PAK2 64.0 1000
PAK3 PAK3 100.0 1000
PAK4 PAK4 100.0 1000
PAK6 PAK6 93.0 1000
PAK5 PAK7 99.0 1000
CDK16 PCTK1 100.0 1000
CDK17 PCTK2 88.0 1000
CDK18 PCTK3 100.0 1000
PDGFRA PDGFRA 100.0 1000
PDGFRB PDGFRB 95.0 1000
PDPK1 PDPK1 93.0 1000
CDPK1 PFCDPK1(P.falciparum) 100.0 1000
PK5 PFPK5(P.falciparum) 100.0 1000
CDK15 PFTAIRE2 100.0 1000
CDK14 PFTK1 100.0 1000
PHKG1 PHKG1 100.0 1000
PHKG2 PHKG2 100.0 1000
PIK3C2B PIK3C2B 86.0 1000
PIK3C2G PIK3C2G 100.0 1000
PIK3CA PIK3CA(Q546K) 88.0 1000
PIK3CB PIK3CB 94.0 1000
PIK3CD PIK3CD 78.0 1000
PIK3CG PIK3CG 79.0 1000
PI4KB PIK4CB 84.0 1000
PIKFYVE PIKFYVE 100.0 1000
PIM1 PIM1 100.0 1000
PIM2 PIM2 100.0 1000
PIM3 PIM3 100.0 1000
PIP5K1A PIP5K1A 63.0 1000
PIP5K1C PIP5K1C 94.0 1000
PIP4K2B PIP5K2B 78.0 1000
PIP4K2C PIP5K2C 100.0 1000
PRKACA PKAC-alpha 100.0 1000
PRKACB PKAC-beta 100.0 1000
PKMYT1 PKMYT1 100.0 1000
PKN1 PKN1 100.0 1000
PKN2 PKN2 100.0 1000
PKNB PKNB(M.tuberculosis) 100.0 1000
PLK1 PLK1 79.0 1000
PLK2 PLK2 74.0 1000
PLK3 PLK3 100.0 1000
PLK4 PLK4 77.0 1000
PRKCD PRKCD 100.0 1000
PRKCE PRKCE 100.0 1000
PRKCH PRKCH 88.0 1000
PRKCI PRKCI 81.0 1000
PRKCQ PRKCQ 93.0 1000
PRKD1 PRKD1 79.0 1000
PRKD2 PRKD2 92.0 1000
PRKD3 PRKD3 100.0 1000
PRKG1 PRKG1 100.0 1000
PRKG2 PRKG2 74.0 1000
EIF2AK2 PRKR 95.0 1000
PRKX PRKX 100.0 1000
PRPF4B PRP4 96.0 1000
PTK2B PYK2 100.0 1000
SIK3 QSK 91.0 1000
RAF1 RAF1 77.0 1000
RET RET(V804M) 100.0 1000
RIOK1 RIOK1 100.0 1000
RIOK2 RIOK2 100.0 1000
RIOK3 RIOK3 87.0 1000
RIPK1 RIPK1 98.0 1000
RIPK2 RIPK2 94.0 1000
RIPK4 RIPK4 84.0 1000
DSTYK RIPK5 95.0 1000
ROCK1 ROCK1 100.0 1000
ROCK2 ROCK2 91.0 1000
ROS1 ROS1 92.0 1000
RPS6KA4 RPS6KA4(Kin.Dom.2-C-terminal) 93.0 1000
RPS6KA5 RPS6KA5(Kin.Dom.2-C-terminal) 90.0 1000
RPS6KA1 RSK1(Kin.Dom.2-C-terminal) 93.0 1000
RPS6KA3 RSK2(Kin.Dom.2-C-terminal) 82.0 1000
RPS6KA2 RSK3(Kin.Dom.2-C-terminal) 100.0 1000
RPS6KA6 RSK4(Kin.Dom.2-C-terminal) 100.0 1000
RPS6KB1 S6K1 99.0 1000
SBK1 SBK1 40.0 1000
SGK1 SGK 100.0 1000
SBK3 SgK110 77.0 1000
SGK2 SGK2 94.0 1000
SGK3 SGK3 93.0 1000
SIK1 SIK 100.0 1000
SIK2 SIK2 100.0 1000
SLK SLK 97.0 1000
NUAK2 SNARK 81.0 1000
SNRK SNRK 78.0 1000
SRC SRC 99.0 1000
SRMS SRMS 100.0 1000
SRPK1 SRPK1 79.0 1000
SRPK2 SRPK2 74.0 1000
SRPK3 SRPK3 100.0 1000
STK16 STK16 100.0 1000
STK33 STK33 100.0 1000
STK35 STK35 100.0 1000
STK36 STK36 100.0 1000
STK39 STK39 100.0 1000
SYK SYK 98.0 1000
MAP3K7 TAK1 100.0 1000
TAOK1 TAOK1 100.0 1000
TAOK2 TAOK2 100.0 1000
TAOK3 TAOK3 100.0 1000
TBK1 TBK1 100.0 1000
TEC TEC 96.0 1000
TESK1 TESK1 100.0 1000
TGFBR1 TGFBR1 80.0 1000
TGFBR2 TGFBR2 93.0 1000
TIE1 TIE1 100.0 1000
TEK TIE2 81.0 1000
TLK1 TLK1 100.0 1000
TLK2 TLK2 100.0 1000
TNIK TNIK 100.0 1000
TNK1 TNK1 100.0 1000
TNK2 TNK2 100.0 1000
TNNI3K TNNI3K 100.0 1000
NTRK1 TRKA 85.0 1000
NTRK2 TRKB 100.0 1000
NTRK3 TRKC 97.0 1000
TRPM6 TRPM6 100.0 1000
TSSK1B TSSK1B 100.0 1000
TSSK3 TSSK3 100.0 1000
TTK TTK 100.0 1000
TXK TXK 100.0 1000
TYK2 TYK2(JH2domain-pseudokinase) 88.0 1000
TYRO3 TYRO3 100.0 1000
ULK1 ULK1 49.0 1000
ULK2 ULK2 100.0 1000
ULK3 ULK3 46.0 1000
KDR VEGFR2 93.0 1000
PIK3C3 VPS34 95.0 1000
VRK2 VRK2 100.0 1000
WEE1 WEE1 94.0 1000
WEE2 WEE2 100.0 1000
WNK1 WNK1 94.0 1000
WNK2 WNK2 100.0 1000
WNK3 WNK3 94.0 1000
WNK4 WNK4 100.0 1000
STK32A YANK1 86.0 1000
STK32B YANK2 90.0 1000
STK32C YANK3 100.0 1000
YES1 YES 100.0 1000
STK25 YSK1 100.0 1000
MAP3K19 YSK4 79.0 1000
MAP3K20 ZAK 95.0 1000
ZAP70 ZAP70 100.0 1000

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BAY-885

Results are showing the remaining kinase activity of the respective kinase after incubation with 1 μM of BAY-885.

Conclusion: Closest hits are FER with 38% activity and EPHB3 with 42 % activity.

Target protein HGNC name Species % residual kinase activity at 1 µM
Abl(h) ABL1 Homo sapiens 100.0
ACK1(h) TNK2 Homo sapiens 101.0
ACTR2(h) ACTR2 Homo sapiens 97.0
ALK(h) ALK Homo sapiens 121.0
ALK1(h) ACVRL1 Homo sapiens 118.0
ALK2(h) ACVR1 Homo sapiens 98.0
ALK4(h) ACVR1B Homo sapiens 98.0
ALK6(h) BMPR1B Homo sapiens 102.0
Arg(h) ABL2 Homo sapiens 93.0
AMPKα1(h) PRKAA1 Homo sapiens 101.0
AMPKα2(h) PRKAA2 Homo sapiens 109.0
A-Raf(h) ARAF Homo sapiens 96.0
ARK5(h) NUAK1 Homo sapiens 101.0
ASK1(h) MAP3K5 Homo sapiens 99.0
Aurora-A(h) AURKA Homo sapiens 109.0
Aurora-B(h) AURKB Homo sapiens 94.0
Aurora-C(h) AURKC Homo sapiens 95.0
Axl(h) AXL Homo sapiens 91.0
Blk(h) BLK Homo sapiens 88.0
BMPR2(h) BMPR2 Homo sapiens 100.0
Bmx(h) BMX Homo sapiens 97.0
BRK(h) PTK6 Homo sapiens 108.0
BrSK1(h) BRSK1 Homo sapiens 104.0
BrSK2(h) BRSK2 Homo sapiens 102.0
BTK(h) BTK Homo sapiens 98.0
B-Raf(h) BRAF Homo sapiens 109.0
CaMKI(h) CAMK1 Homo sapiens 109.0
CaMKIß(h) PNCK Homo sapiens 104.0
CaMKIγ(h) CAMK1G Homo sapiens 103.0
CaMKIIalpha(h) CAMK2A Homo sapiens 108.0
CaMKIIbeta (h) CAMK2B Homo sapiens 103.0
CaMKIIgamma (h) CAMK2G Homo sapiens 93.0
CaMKIdelta(h) CAMK1D Homo sapiens 94.0
CaMKIIdelta (h) CAMK2D Homo sapiens 95.0
CaMKIV(h) CAMK4 Homo sapiens 96.0
CaMKK1(h) CAMKK1 Homo sapiens 102.0
CaMKK2(h) CAMKK2 Homo sapiens 102.0
Cdc7/cyclinB1(h) CDK7 Homo sapiens 112.0
CDK1/cyclinB(h) CDK1 Homo sapiens 101.0
CDK2/cyclinA(h) CDK2 Homo sapiens 105.0
CDK2/cyclinE(h) CDK2 Homo sapiens 99.0
CDK3/cyclinE(h) CDK3 Homo sapiens 106.0
CDK4/cyclinD3(h) CDK4 Homo sapiens 106.0
CDK5/p25(h) CDK5 Homo sapiens 106.0
CDK5/p35(h) CDK5 Homo sapiens 107.0
CDK6/cyclinD3(h) CDK6 Homo sapiens 96.0
CDK7/cyclinH/MAT1(h) CDK7 Homo sapiens 99.0
CDK9/cyclin T1(h) CDK9 Homo sapiens 103.0
CDK12/cyclinK(h) CDK12 Homo sapiens 94.0
CDK13/cyclinK(h) CDK13 Homo sapiens 109.0
CDK14/cyclinY(h) CDK14 Homo sapiens 117.0
CDK18/cyclinY(h) CDK18 Homo sapiens 100.0
CDKL1(h) CDKL1 Homo sapiens 115.0
CDKL2(h) CDKL2 Homo sapiens 96.0
CDKL3(h) CDKL3 Homo sapiens 113.0
CDKL4(h) CDKL4 Homo sapiens 103.0
ChaK1(h) TRPM7 Homo sapiens 122.0
CHK1(h) CHEK1 Homo sapiens 89.0
CHK2(h) CHEK2 Homo sapiens 92.0
CK1gamma1 (h) CSNK1G1 Homo sapiens 105.0
CK1gamma2 (h) CSNK1G2 Homo sapiens 91.0
CK1gamma3 (h) CSNK1G3 Homo sapiens 96.0
CK1delta (h) CSNK1D Homo sapiens 116.0
CK2(h) CSNK2A1 Homo sapiens 107.0
CK2α1(h) CSNK2A1 Homo sapiens 92.0
CK2alpha2 (h) CSNK2A2 Homo sapiens 94.0
CLIK1(h) STK35 Homo sapiens 116.0
CLK1(h) CLK1 Homo sapiens 105.0
CLK2(h) CLK2 Homo sapiens 109.0
CLK3(h) CLK3 Homo sapiens 111.0
CLK4(h) CLK4 Homo sapiens 118.0
cKit(h) KIT Homo sapiens 104.0
CSK(h) CSK Homo sapiens 102.0
c-RAF(h) RAF1 Homo sapiens 107.0
cSRC(h) SRC Homo sapiens 113.0
DAPK1(h) DAPK1 Homo sapiens 109.0
DAPK2(h) DAPK2 Homo sapiens 99.0
DCAMKL2(h) DCLK2 Homo sapiens 90.0
DCAMKL3(h) DCLK3 Homo sapiens 92.0
DDR1(h) DDR1 Homo sapiens 100.0
DDR2(h) DDR2 Homo sapiens 104.0
DMPK(h) DMPK Homo sapiens 97.0
DRAK1(h) STK17A Homo sapiens 85.0
DRAK2(h) STK17B Homo sapiens 117.0
DYRK1A(h) DYRK1A Homo sapiens 112.0
DYRK1B(h) DYRK1B Homo sapiens 106.0
DYRK2(h) DYRK2 Homo sapiens 105.0
DYRK3(h) DYRK3 Homo sapiens 103.0
eEF-2K(h) EEF2K Homo sapiens 113.0
EGFR(h) EGFR Homo sapiens 105.0
EphA1(h) EPHA1 Homo sapiens 106.0
EphA2(h) EPHA2 Homo sapiens 100.0
EphA3(h) EPHA3 Homo sapiens 86.0
EphA4(h) EPHA4 Homo sapiens 82.0
EphA5(h) EPHA5 Homo sapiens 57.0
EphA7(h) EPHA7 Homo sapiens 92.0
EphA8(h) EPHA8 Homo sapiens 104.0
EphB2(h) EPHB2 Homo sapiens 93.0
EphB1(h) EPHB1 Homo sapiens 105.0
EphB3(h) EPHB3 Homo sapiens 42.0
EphB4(h) EPHB4 Homo sapiens 103.0
ErbB2(h) ERBB2 Homo sapiens 96.0
ErbB4(h) ERBB4 Homo sapiens 98.0
FAK(h) PTK2 Homo sapiens 101.0
Fer(h) FER Homo sapiens 38.0
Fes(h) FES Homo sapiens 108.0
FGFR1(h) FGFR1 Homo sapiens 101.0
FGFR2(h) FGFR2 Homo sapiens 107.0
FGFR3(h) FGFR3 Homo sapiens 106.0
FGFR4(h) FGFR4 Homo sapiens 96.0
Fgr(h) FGR Homo sapiens 98.0
Flt1(h) FLT1 Homo sapiens 108.0
Flt3(h) FLT3 Homo sapiens 100.0
Flt4(h) FLT4 Homo sapiens 98.0
Fms(h) CSF1R Homo sapiens 118.0
Fyn(h) FYN Homo sapiens 129.0
GCK(h) GCK Homo sapiens 90.0
GCN2(h) EIF2AK4 Homo sapiens 98.0
GRK1(h) GRK1 Homo sapiens 117.0
GRK2(h) GRK2 Homo sapiens 85.0
GRK3(h) GRK3 Homo sapiens 92.0
GRK5(h) GRK5 Homo sapiens 85.0
GRK6(h) GRK6 Homo sapiens 111.0
GRK7(h) GRK7 Homo sapiens 101.0
GSK3alpha (h) GSK3A Homo sapiens 112.0
GSK3beta (h) GSK3B Homo sapiens 99.0
Haspin(h) HASPIN Homo sapiens 105.0
Hck(h) HCK Homo sapiens 95.0
Hck(h) activated HCK Homo sapiens 107.0
HIPK1(h) HIPK1 Homo sapiens 116.0
HIPK2(h) HIPK2 Homo sapiens 107.0
HIPK3(h) HIPK3 Homo sapiens 108.0
HIPK4(h) HIPK4 Homo sapiens 94.0
HPK1(h) MAP4K1 Homo sapiens 106.0
HRI(h) EIF2AK1 Homo sapiens 104.0
ICK(h) CILK1 Homo sapiens 93.0
IGF-1R(h) IGF1R Homo sapiens 90.0
IGF-1R(h), activated IGF1R Homo sapiens 107.0
IKKalpha (h) CHUK Homo sapiens 99.0
IKKbeta (h) IKBKB Homo sapiens 106.0
IKKepsilon(h) IKBKE Homo sapiens 107.0
IR(h) INSR Homo sapiens 107.0
IR(h), activated INSR Homo sapiens 99.0
IRE1(h) ERN1 Homo sapiens 110.0
IRR(h) INSRR Homo sapiens 111.0
IRAK1(h) IRAK1 Homo sapiens 110.0
IRAK4(h) IRAK4 Homo sapiens 106.0
Itk(h) ITK Homo sapiens 105.0
JAK1(h) JAK1 Homo sapiens 104.0
JAK2(h) JAK2 Homo sapiens 100.0
JAK3(h) JAK3 Homo sapiens 118.0
JNK1alpha1 (h) MAPK8 Homo sapiens 104.0
JNK2alpha2 (h) MAPK9 Homo sapiens 104.0
JNK3(h) MAPK10 Homo sapiens 111.0
KDR(h) KDR Homo sapiens 100.0
Lck(h) LCK Homo sapiens 98.0
Lck(h) activated LCK Homo sapiens 105.0
LIMK1(h) LIMK1 Homo sapiens 93.0
LIMK2(h) LIMK2 Homo sapiens 104.0
LKB1(h) STK11 Homo sapiens 104.0
LOK(h) STK10 Homo sapiens 114.0
Lyn(h) LYN Homo sapiens 100.0
LRRK2(h) LRRK2 Homo sapiens 102.0
LTK(h) LTK Homo sapiens 103.0
MAK(h) MAK Homo sapiens 125.0
MAPK1(h) MAPK1 Homo sapiens 116.0
MAPK2(h) MAPK2 Homo sapiens 107.0
MAP4K3(h) MAP4K3 Homo sapiens 102.0
MAP4K4(h) MAP4K4 Homo sapiens 99.0
MAP4K5(h) MAP4K5 Homo sapiens 99.0
MAPKAP-K2(h) MAPKAPK2 Homo sapiens 81.0
MAPKAP-K3(h) MAPKAPK3 Homo sapiens 113.0
MEK1(h) MAP2K1 Homo sapiens 115.0
MEK2(h) MAP2K2 Homo sapiens 103.0
MARK1(h) MARK1 Homo sapiens 112.0
MARK3(h) MARK3 Homo sapiens 100.0
MARK4(h) MARK4 Homo sapiens 100.0
MEKK2(h) MAP3K2 Homo sapiens 116.0
MEKK3(h) MAP3K3 Homo sapiens 94.0
MELK(h) MELK Homo sapiens 105.0
Mer(h) MERTK Homo sapiens 91.0
Met(h) MET Homo sapiens 93.0
MINK(h) MINK1 Homo sapiens 98.0
MKK3(h) MAP2K3 Homo sapiens 92.0
MKK6(h) MAP2K6 Homo sapiens 99.0
MKK7beta (h) MAP2K7 Homo sapiens 106.0
MLCK(h) MYLK3 Homo sapiens 107.0
MLK1(h) MAP3K9 Homo sapiens 108.0
MLK2(h) MAP3K10 Homo sapiens 107.0
MLK3(h) MAP3K11 Homo sapiens 112.0
Mnk2(h) MKNK2 Homo sapiens 99.0
MOK(h) MOK Homo sapiens 94.0
MRCKalpha (h) CDC42BPA Homo sapiens 111.0
MRCKbeta (h) CDC42BPB Homo sapiens 110.0
MSK1(h) RPS6KA5 Homo sapiens 97.0
MSK2(h) RPS6KA4 Homo sapiens 107.0
MSSK1(h) SRPK3 Homo sapiens 78.0
MST1(h) STK4 Homo sapiens 117.0
MST2(h) STK3 Homo sapiens 128.0
MST3(h) STK24 Homo sapiens 99.0
MST4(h) STK26 Homo sapiens 103.0
mTOR(h) MTOR Homo sapiens 104.0
mTOR/FKBP12(h) MTOR Homo sapiens 101.0
MuSK(h) MUSK Homo sapiens 130.0
MYLK2(h) MYLK2 Homo sapiens 93.0
MYO3B(h) MYO3B Homo sapiens 111.0
NDR2(h) STK38L Homo sapiens 100.0
NEK1(h) NEK1 Homo sapiens 98.0
NEK2(h) NEK2 Homo sapiens 111.0
NEK4(h) NEK4 Homo sapiens 114.0
NEK3(h) NEK3 Homo sapiens 111.0
NEK6(h) NEK6 Homo sapiens 125.0
NEK7(h) NEK7 Homo sapiens 106.0
NEK9(h) NEK9 Homo sapiens 92.0
NIM1(h) NIM1K Homo sapiens 108.0
NEK11(h) NEK11 Homo sapiens 104.0
NLK(h) NLK Homo sapiens 111.0
NUAK2(h) NUAK2 Homo sapiens 111.0
p70S6K(h) RPS6KB1 Homo sapiens 118.0
PAK1(h) PAK1 Homo sapiens 95.0
PAK2(h) PAK2 Homo sapiens 108.0
PAK4(h) PAK4 Homo sapiens 101.0
PAK3(h) PAK3 Homo sapiens 106.0
PAK5(h) PAK5 Homo sapiens 115.0
PAK6(h) PAK6 Homo sapiens 103.0
PAR-1Balpha (h) MARK2 Homo sapiens 113.0
PASK(h) PASK Homo sapiens 107.0
PEK(h) EIF2AK3 Homo sapiens 100.0
PDGFRalpha (h) PDGFRA Homo sapiens 105.0
PDGFRbeta(h) PDGFRB Homo sapiens 107.0
PDHK2(h) PDK2 Homo sapiens 97.0
PDHK4(h) PDK4 Homo sapiens 104.0
PDK1(h) PDK1 Homo sapiens 89.0
PhKgamma1(h) PHKG1 Homo sapiens 103.0
PhKgamma2 (h) PHKG2 Homo sapiens 112.0
Pim-1(h) PIM1 Homo sapiens 111.0
Pim-2(h) PIM2 Homo sapiens 110.0
Pim-3(h) PIM3 Homo sapiens 102.0
PKA(h) PRKACA Homo sapiens 99.0
PKAcβ(h) PRKACB Homo sapiens 89.0
PKBalpha (h) AKT1 Homo sapiens 113.0
PKBbeta (h) AKT2 Homo sapiens 109.0
PKBgamma (h) AKT3 Homo sapiens 113.0
PKCalpha (h) PRKCA Homo sapiens 107.0
PKCbetaI (h) PRKCB Homo sapiens 110.0
PKCbetaII (h) PRKCB Homo sapiens 112.0
PKCgamma(h) PRKCG Homo sapiens 120.0
PKCdelta (h) PRKCD Homo sapiens 115.0
PKCepsilon (h) PRKCE Homo sapiens 104.0
PKCeta (h) PRKCH Homo sapiens 115.0
PKCiota (h) PRKCI Homo sapiens 102.0
PKCmu (h) PRKD1 Homo sapiens 127.0
PKCtheta (h) PRKCQ Homo sapiens 115.0
PKCzeta(h) PRKCZ Homo sapiens 114.0
PKD2(h) PRKD2 Homo sapiens 106.0
PKD3(h) PRKD3 Homo sapiens 100.0
PKG1alpha (h) PRKG1 Homo sapiens 115.0
PKG1beta (h) PRKG1 Homo sapiens 122.0
PKR(h) EIF2AK2 Homo sapiens 115.0
Plk1(h) PLK1 Homo sapiens 115.0
Plk3(h) PLK3 Homo sapiens 107.0
Plk4(h) PLK4 Homo sapiens 88.0
PRAK(h) MAPKAPK5 Homo sapiens 109.0
PRKG2(h) PRKG2 Homo sapiens 127.0
PRK1(h) PKN1 Homo sapiens 114.0
PRK2(h) PKN2 Homo sapiens 104.0
PrKX(h) PRKX Homo sapiens 121.0
PRP4(h) PRPF4B Homo sapiens 97.0
PTK5(h) FRK Homo sapiens 109.0
Pyk2(h) PTK2B Homo sapiens 103.0
Ret(h) RET Homo sapiens 122.0
RIPK1(h) RIPK1 Homo sapiens 100.0
RIPK2(h) RIPK2 Homo sapiens 101.0
ROCK-I(h) ROCK1 Homo sapiens 112.0
ROCK-II(h) ROCK2 Homo sapiens 91.0
Ron(h) MST1R Homo sapiens 100.0
Ros(h) ROS1 Homo sapiens 111.0
Rse(h) TYRO3 Homo sapiens 100.0
Rsk1(h) RPS6KA1 Homo sapiens 121.0
Rsk2(h) RPS6KA3 Homo sapiens 109.0
Rsk3(h) RPS6KA2 Homo sapiens 98.0
Rsk4(h) RPS6KA6 Homo sapiens 103.0
SAPK2a(h) MAPK14 Homo sapiens 113.0
SAPK2b(h) MAPK11 Homo sapiens 103.0
SAPK3(h) MAPK12 Homo sapiens 112.0
SAPK4(h) MAPK13 Homo sapiens 112.0
SBK1(h) SBK1 Homo sapiens 96.0
SGK(h) SGK1 Homo sapiens 113.0
SGK2(h) SGK2 Homo sapiens 89.0
SGK3(h) SGK3 Homo sapiens 104.0
SIK(h) SIK1 Homo sapiens 99.0
SIK2(h) SIK2 Homo sapiens 101.0
SIK3(h) SIK3 Homo sapiens 96.0
SLK(h) SLK Homo sapiens 87.0
Snk(h) PLK2 Homo sapiens 119.0
SNRK(h) SNRK Homo sapiens 118.0
SRMS(h) SRMS Homo sapiens 81.0
SRPK1(h) SRPK1 Homo sapiens 114.0
SRPK2(h) SRPK2 Homo sapiens 99.0
STK16(h) STK16 Homo sapiens 99.0
STK25(h) STK25 Homo sapiens 87.0
STK32A(h) STK32A Homo sapiens 100.0
STK32B(h) STK32B Homo sapiens 98.0
STK32C(h) STK32C Homo sapiens 103.0
STK33(h) STK33 Homo sapiens 103.0
Syk(h) SYK Homo sapiens 87.0
TAF1L(h) TAF1L Homo sapiens 120.0
TAK1(h) MAP3K7 Homo sapiens 107.0
TAO1(h) TAOK1 Homo sapiens 100.0
TAO2(h) TAOK2 Homo sapiens 113.0
TAO3(h) TAOK3 Homo sapiens 110.0
TBK1(h) TBK1 Homo sapiens 118.0
Tec(h) activated TEC Homo sapiens 112.0
TGFBR1(h) TGFBR1 Homo sapiens 81.0
TGFBR2(h) TGFBR2 Homo sapiens 108.0
Tie2 (h) TEK Homo sapiens 84.0
TLK1(h) TLK1 Homo sapiens 106.0
TLK2(h) TLK2 Homo sapiens 98.0
TNIK(h) TNIK Homo sapiens 89.0
TRB2(h) TRIB2 Homo sapiens 109.0
TrkA(h) NTRK1 Homo sapiens 110.0
TrkB(h) NTRK2 Homo sapiens 98.0
TrkC(h) NTRK3 Homo sapiens 123.0
TSSK1(h) TSSK1B Homo sapiens 107.0
TSSK2(h) TSSK2 Homo sapiens 113.0
TSSK3(h) TSSK3 Homo sapiens 108.0
TSSK4(h) TSSK4 Homo sapiens 115.0
TTBK1(h) TTBK1 Homo sapiens 95.0
TTBK2(h) TTBK2 Homo sapiens 98.0
TTK(h) TTK Homo sapiens 93.0
Txk(h) TXK Homo sapiens 99.0
TYK2(h) TYK2 Homo sapiens 110.0
ULK1(h) ULK1 Homo sapiens 97.0
ULK2(h) ULK2 Homo sapiens 102.0
ULK3(h) ULK3 Homo sapiens 98.0
VRK1(h) VRK1 Homo sapiens 100.0
VRK2(h) VRK2 Homo sapiens 106.0
Wee1(h) WEE1 Homo sapiens 108.0
Wee1B(h) WEE2 Homo sapiens 124.0
WNK1(h) WNK1 Homo sapiens 105.0
WNK2(h) WNK2 Homo sapiens 107.0
WNK3(h) WNK3 Homo sapiens 107.0
Yes(h) YES1 Homo sapiens 99.0
ZAK(h) MAP3K20 Homo sapiens 100.0
ZAP-70(h) ZAP70 Homo sapiens 108.0
ZIPK(h) DAPK3 Homo sapiens 111.0
ATM(h) ATM Homo sapiens 107.0
ATR/ATRIP(h) ATR Homo sapiens 100.0
DNA-PK(h) PRKDC Homo sapiens 102.0
PI3 Kinase(p110b/p85a)(h) PIK3CB Homo sapiens 98.0
PI3 Kinase (p120g)(h) PIK3CG Homo sapiens 100.0
PI3 Kinase(p110d/p85a)(h) PIK3CD Homo sapiens 102.0
PI3 Kinase(p110a/p85a)(h) PIK3CA Homo sapiens 98.0
PI3KC2a(h) PIK3C2A Homo sapiens 96.0
PI3KC2g(h) PIK3C2G Homo sapiens 94.0
PIP4K2a(h) PIP4K2A Homo sapiens 95.0
PIP5K1a(h) PIP5K1A Homo sapiens 98.0
PIP5K1g(h) PIP5K1C Homo sapiens 93.0