Potency data for probe BAY-9835 and control BAY-1880
In vitro potency
| Target name | Target information | Species | Assay description | BAY-9835 | BAY-1880 | Publication of assay conditions |
|---|---|---|---|---|---|---|
| ADAMTS7 | recombinant protein | Homo sapiens | Biochemical enzymatic FRET assay (hADAMTS7): FRET substrate, HiLyteFluor-488 DELSSMVLELRGLRT-K(QXL520)-E-NH2 (custom synthesis by Anaspec) was used. | IC50 = 6 nM | IC50 = 23.4 µM | PMID: 38348661 (supplement) |
| ADAMTS12 | recombinant protein | Homo sapiens | Biochemical enzymatic FRET assay (hADAMTS12): FRET substrate, HiLyteFluor-488 DELSSMVLELRGLRT-K(QXL520)-E-NH2 (custom synthesis by Anaspec) was used. | IC50 = 30 nM | PMID: 38348661 (supplement) | |
| ADAMTS7 | recombinant protein | Mus musculus | Biochemical enzymatic FRET assay (mouse ADAMTS7): FRET substrate, HiLyteFluor-488 DELSSMVLELRGLRT-K(QXL520)-E-NH2 (custom synthesis by Anaspec) was used. | IC50 = 8 nM | PMID: 38348661 (supplement) | |
| ADAMTS7 | recombinant protein | Rattus norvegicus | Biochemical enzymatic FRET assay (rat ADAMTS7): FRET substrate, HiLyteFluor-488 DELSSMVLELRGLRT-K(QXL520)-E-NH2 (custom synthesis by Anaspec) was used. | IC50 = 27 nM | PMID: 38348661 (supplement) | |
| ADAMTS4 | recombinant protein | Homo sapiens | Biochemical enzymatic FRET assay (hADAMTS4): FRET substrate, HiLyteFluor-488 DELSSMVLELRGLRT-K(QXL520)-E-NH2 (custom synthesis by Anaspec) was used. | IC50 > 50 µM | PMID: 38348661 (supplement) |
No in cell potency data available.