Physicochemical properties of probe BAY-9835 and control BAY-1880
| BAY-9835 | |
|---|---|
| TPSA | 105 Å2 |
| Tablet blend for 13 weeks | stable |
| log D (pH 7.5) | 2.3 |
| Ligand-lipophilicity efficiency (LLE) (based on hIC50) | 5.9 |
| Binding efficiency index (BEI) | 19.0 |
| BAY-1880 | |
|---|---|
| TPSA | 105 Å2 |
| Stability in solution (pH1, pH7, pH10, 24 h) | stable |
| log D (pH 7.5) | 2.2 |
| Ligand-lipophilicity efficiency (LLE) (based on hIC50) | 2.4 |
| Binding efficiency index (BEI) | 11.0 |
Solubility
| BAY-9835: |
Aqueous pH7 (after 24h, at 25°C): 135 mg/L,
FASSIF (after 24h, 37°C): 297 mg/L,
FESSIF (after 24H, 37°C): 513 mg/L
|
| BAY-1880: |
Aqueous pH 7: > 500 mg/L
|