Potency data for probe BI-1230 and control BI-1675
In vitro potency
| Target name | Target information | Species | Assay description | BI-1230 | BI-1675 | Publication of assay conditions |
|---|---|---|---|---|---|---|
| HCV NS3 | Hepacivirus C | Enzymatic assay : NS3-NS4A heterodimer, fluorogenic substrate, 60 min incubation | IC50 = 6.7 nM | IC50 = 4870 nM |
In cell potency
| Target name | Target information | Species | Assay description | BI-1230 | BI-1675 | Publication of assay conditions |
|---|---|---|---|---|---|---|
| HCV NS3 | Hepacivirus C | HCVPV RNA replication Luciferase reporter assay, genotype 1a: Huh7 cells, 72 h incubation | EC50 = 4.6 nM | PMID: 12671967 | ||
| HCV NS3 | Hepacivirus C | HCVPV RNA replication Luciferase reporter assay, genotype 1b: Huh7 cells, 72 h incubation | EC50 < 1.8 nM | PMID: 12671967 |