Potency data for probe BI-1942
In vitro potency
| Target name | Target information | Species | Assay description | Probe result (SD) | Publication of assay conditions |
|---|---|---|---|---|---|
| CMA1 | recombinant human chymase | Homo sapiens | Inhibition of CMA1: Incubation for 1 h at 28°C/ fluorescence measurement | IC50 = 0.400 nM | PMID: 23659209 |
In cell potency
| Target name | Target information | Species | Assay description | Probe result (SD) | Publication of assay conditions |
|---|---|---|---|---|---|
| CMA1 | human plasma | Homo sapiens | Angiotensin II formation by CMA1 in human plasma: Reactive metabolite formation | IC50 = 198 nM | PMID: 23659209 |