Potency data for probe BI-1950 and control BI-9446
In vitro potency
| Target name | Target information | Species | Assay description | Probe result (SD) | Control result (SD) | Publication of assay conditions |
|---|---|---|---|---|---|---|
| ITGAL | Homo sapiens | ITGAL binding assay: Inhibition of ITGAL binding to ICAM1 | Kd = 9 nM | Kd > 1 µM | PMID: 10553036 |
In cell potency
| Target name | Target information | Species | Assay description | Probe result (SD) | Control result (SD) | Publication of assay conditions |
|---|---|---|---|---|---|---|
| ITGAL | Homo sapiens | Inhibition of staphylococcal enterotoxin B-induced production of IL2 in human whole blood | IC50 = 120 nM | IC50 > 1 µM | PMID: 10553036 | |
| ITGAL | Homo sapiens | Inhibition of staphylococcal enterotoxin B-induced production of IL2 in human PBMC cells | IC50 = 3 nM | PMID: 10553036 |