BI-1950

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1H NMR (500 MHz, DMSO-d6)

δ 9.05 (s, J = 3.7 Hz, 1H), 8.74 (d, J = 6.4 Hz, 1H), 8.56 (m, J = 4.8 Hz, 1H), 8.06 (s, 1H), 7.83 (m, J = 6.2 Hz, 1H), 7.77 (d, J = 6.0 Hz, 2H), 7.73 (s, 1H), 7.67 – 7.63 (m, 2H), 7.49 (s, 1H), 7.03 – 7.00 (m, 2H), 4.46 (p, J = 7.0 Hz, 1H), 4.08 (d, J = 13.4 Hz, 1H), 3.40 (d, J = 13.3 Hz, 1H), 2.39 – 2.37 (s, 2H) CH3 of mesylate, 1.87 (s, 3H), 1.69 – 1.56 (br, 2H), 1.41 (d, J = 7.1 Hz, 3H), 1.25-1.33 (br, J = 9.8 Hz, 2H).

13C NMR (126 MHz, DMSO-d6)

δ 175.02, 174.44, 159.54, 147.81, 140.75, 132.71, |1J (C, F)|:132.63-130.66, 124.37, 123.49, 121.94, 121.79, 118.91, 110.70, 69.11, 49.83, 42.48, 35.24, 21.97, 20.10, 19.82, 17.55.

BI-9446

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MS (ESI pos.)	m/z = 602.1 ([M+H]+, calcd. 602.2)
1H-NMR (500 MHz, DMSO-d6, 300K)	δ = 9.56 (s, 1H), 7.70 (d, 4J = 1.9 Hz, 2H), 7.66 – 7.62 (m, 4H), 7.07 (d, 3J = 8.3 Hz, 2H), 3.87 (d, 2J = 13.5 Hz, 1H), 3.59 (p, 3J = 8.4 Hz, 1H), 3.36 (d, 2J = 13.4 Hz, 1H), 2.29 – 2.15 (m, 4H), 2.05 – 1.95 (m, 1H), 1.89 (s, 3H), 1.84 – 1.66 (m, 3H), 1.62 – 1.51 (m, 2H) ppm
13C-NMR (126 MHz, DMSO-d6, 300K)	δ = 180.6, 174.6, 172.7, 160.1, 147.7, 140.2, 134.5, 134.3, 132.4, 132.1, 130.2, 126.8, 123.7, 120.6, 118.4, 110.3, 68.7, 62.0, 41.7, 30.3, 29.6, 26.3 (d, J = 5.4 Hz), 20.9, 18.9, 18.5, 18.3 ppm
HPLC	tR = 7.777 min; purity: ≥95%