Potency data for probe BI-4394 and control BI-4395
In vitro potency
| Target name | Target information | Species | Assay description | BI-4394 | BI-4395 | Publication of assay conditions |
|---|---|---|---|---|---|---|
| MMP13 | Recombinant E. coli; catalytic domains | Homo sapiens | Biochemical assay (FRET) with MMP13 | IC50 = 1 nM | IC50 > 26 µM | PMID: 22017539 |
| MMP13 | full length | Homo sapiens | Bovine nasal cartilage (BNC) degradation assay: ELISA (inhibition of full-length MMP-13-induced cartilage degradation) | IC50 = 31 nM | PMID: 22017539 | |
| MMP13 | full length | Homo sapiens | MMP13 collagen degradation assay: Rapid Collagen Assay from Condrex | IC50 = 11 nM | PMID: 22017539 | |
| MMP1 | catalytic domain | Homo sapiens | Biochemical assay (FRET) (MMP1) | IC50 > 22 µM | PMID: 22017539 | |
| MMP2 | catalytic domain | Homo sapiens | Biochemical assay (FRET) with MMP2 | IC50 = 18 µM | PMID: 22017539 | |
| MMP3 | catalytic domain | Homo sapiens | Biochemical assay (FRET) with MMP3 | IC50 > 22 µM | PMID: 22017539 | |
| MMP7 | catalytic domain | Homo sapiens | Biochemical assay (FRET) with MMP7 | IC50 > 22 µM | PMID: 22017539 | |
| MMP8 | catalytic domain | Homo sapiens | Biochemical assay (FRET) with MMP8 | IC50 > 22 µM | PMID: 22017539 | |
| MMP9 | catalytic domain | Homo sapiens | Biochemical assay (FRET) with MMP9 | IC50 = 8.9 µM | PMID: 22017539 | |
| MMP10 | catalytic domain | Homo sapiens | Biochemical assay (FRET) with MMP10 | IC50 = 16 µM | PMID: 22017539 | |
| MMP12 | catalytic domain | Homo sapiens | Biochemical assay (FRET) with MMP12 | IC50 > 22 µM | PMID: 22017539 | |
| MMP14 | catalytic domain | Homo sapiens | Biochemical assay (FRET) with MMP14 | IC50 = 8.3 µM | PMID: 22017539 |
No in cell potency data available.