In cells

Use at concentration of 0.1 µM.

We recommend to use the MMP13 inhibitor T-26c also available from SGC for control experiments.

Use the recommended concentration to avoid off-target toxicity and/or off-target activity. Using concentrations that are higher than recommended could lead to false positive or confounding results.

In vivo

Clearance [(mL/min kg)]^b = 39; Mean residence time after iv dose [h] ( 1 mg/kg) = 0.5; F [%] = 39; Vss [l/kg] = 0.4