In cells

Use at concentration of 0.1 μM.

We recommend to use the MMP13 inhibitor BI-4394 also available from SGC for control experiments.

Use the recommended concentration to avoid off-target toxicity and/or off-target activity. Using concentrations that are higher than recommended could lead to false positive or confounding results.

In vivo

Can be used for in vivo studies: In a preliminary two-week toxicological study in rats, none of the symptoms associated with toxicity were observed up to a dose of 60 mg/kg/day.