Potency data for probe T-26c and control T-26f
In vitro potency
| Target name | Target information | Species | Assay description | Compound conc. | T-26c | T-26f | Publication of assay conditions |
|---|---|---|---|---|---|---|---|
| MMP13 | catalytic domain | Homo sapiens | MMP inhibition assay (MMP13) | IC50 = 6.9 pM ± 0.780 pM (n=3) | PMID: 25192810 | ||
| Ex Vivo Bovine Nasal Cartilage Explant Model | Bos taurus | Assay for inhibitory activity against collagen degradation: Inhibition of collagen breakdown in IL-1beta and oncostatin M stimulated cartilage | 0.1 µM | Inhibition = 87% | PMID: 25192810 | ||
| MMP1 | Homo sapiens | MMP inhibition assay (MMP1) | IC50 > 10 µM (n=3) | PMID: 25192810 | |||
| MMP2 | Homo sapiens | MMP inhibition assay (MMP2) | IC50 = 18 nM ± 3.600 nM (n=3) | PMID: 25192810 | |||
| MMP3 | Homo sapiens | MMP inhibition assay (MMP3) | IC50 = 600 nM ± 220.000 nM (n=3) | PMID: 25192810 | |||
| MMP7 | Homo sapiens | MMP inhibition assay (MMP7) | IC50 > 10 µM (n=3) | PMID: 25192810 | |||
| MMP8 | Homo sapiens | MMP inhibition assay (MMP8) | IC50 = 780 nM ± 290.000 nM (n=3) | PMID: 25192810 | |||
| MMP9 | Homo sapiens | MMP inhibition assay (MMP9) | IC50 > 10 µM (n=3) | PMID: 25192810 | |||
| MMP10 | Homo sapiens | MMP inhibition assay (MMP10) | IC50 = 160 nM ± 35.000 nM (n=3) | PMID: 25192810 | |||
| MMP14 | Homo sapiens | MMP inhibition assay (MMP14) | IC50 > 10 µM (n=3) | PMID: 25192810 | |||
| ADAM17 | Homo sapiens | MMP inhibition assay (ADAM17) | IC50 > 10 µM (n=3) | PMID: 25192810 | |||
| MMP13 | catalytic domain | Homo sapiens | MMP inhibition assay (MMP13) | IC50 = 39 nM (n=3) |
No in cell potency data available.