Potency data for probe BI-9627 and control BI-0054
In vitro potency
| Target name | Target information | Species | Assay description | BI-9627 | BI-0054 | Publication of assay conditions |
|---|---|---|---|---|---|---|
| SLC9A1 | Homo sapiens | pHi change assay with SLC9A1 | IC50 = 6 nM | IC50 > 10 µM | PMID: 22803959 | |
| SLC9A2 | Homo sapiens | pHi change assay with SLC9A2 | IC50 = 231 nM | IC50 > 10 µM | PMID: 22803959 | |
| SLC9A3 | Homo sapiens | pHi change assay with SLC9A3 | IC50 > 16 µM | IC50 > 10 µM | PMID: 22803959 |
In cell potency
| Target name | Target information | Species | Assay description | BI-9627 | BI-0054 | Publication of assay conditions |
|---|---|---|---|---|---|---|
| SLC9A1 | Homo sapiens | Human platelet swelling inhibition (hPSA) assay | IC50 = 31 nM | IC50 > 10 µM | PMID: 22803959 | |
| SLC9A1 | Rattus sp. | Rat platelet swelling inhibition (rPSA) assay | IC50 = 138 nM | PMID: 22803959 |