Potency data for probe GSM1 and control GSM-NC
No in vitro potency data available.
In cell potency
| Target name | Target information | Species | Assay description | GSM1 | GSM-NC | Publication of assay conditions |
|---|---|---|---|---|---|---|
| APP | SH-SY5Y (SP4CT) cells | Homo sapiens | Aβ42 inhibition assay | IC50 = 31 nM (n=9) | IC50 > 10 µM | PMID: 26142947 |
| APP | SH-SY5Y (SP4CT) cells | Homo sapiens | Aβ40 inhibition assay | IC50 = 131 nM | IC50 > 10 µM | PMID: 26142947 |
| Notch | Homo sapiens | Notch assay: A split-luciferase system in HeLa cells expressing Notch is used to detect NICD levels by measuring total luminescence upon addition of luciferin to lysed cells. | IC50 = 397.8 µM | IC50 > 50 µM | PMID: 26142947 | |
| SLC6A3 | Homo sapiens | Dopamine-uptake assay | IC50 = 536 nM | |||
| Homo sapiens | Serotonin-uptake assay | IC50 = 13 nM |