Potency data for probe JNJ-54082730 and control JNJ-54103985
In vitro potency
| Target name | Target information | Species | Assay description | JNJ-54082730 | JNJ-54103985 | Publication of assay conditions |
|---|---|---|---|---|---|---|
| PDE2A | Homo sapiens | Scintillation proximity assay (PDE2A): Mean (95% Confidence Interval) = 0.8 -1 nM; Ki = 0.7 nM | IC50 = 0.9 nM (n=93) | IC50 = 97 nM (n=93) | ||
| PDE10A | Homo sapiens | Scintillation proximity assay (PDE10A) | IC50 > 10 µM | |||
| PDE3A, PDE3B | Homo sapiens | Scintillation proximity assay (PDE3) | IC50 > 10 µM |
In cell potency
| Target name | Target information | Species | Assay description | JNJ-54082730 | JNJ-54103985 | Publication of assay conditions |
|---|---|---|---|---|---|---|
| PDE2A | rat brain (striatum) | Rattus norvegicus | Target occupancy in striatum: p.o.dose, 1 h | ED50 = 5.3 mg/kg | ED50 > 80 mg/kg |