In cells

Coming soon

Use the recommended concentration to avoid off-target toxicity and/or off-target activity. Using concentrations that are higher than recommended could lead to false positive or confounding results.

In vivo

Tested in dogs (dose: 0.5 – 1 mg/kg) and rats. Binds to PDE2 in rat brain with the occupancy correlating with exposure (dose: 0.6 to 40 mg/kg, PO, 1 h). Enhances cGMP in primary rat hippocampal cultures; Functional cGMP increase in dog CSF (cerebrospinal fluid).