Potency data for probe MRL-650 and control MRL-CB1-NC
In vitro potency
| Target name | Target information | Species | Assay description | MRL-650 | MRL-CB1-NC | Publication of assay conditions |
|---|---|---|---|---|---|---|
| CNR1 | Homo sapiens | Radioligand Binding Assay (CNR1): Measurement of the reduction in binding of [3H]CP-55940 (a hCB1r agonist) to recombinant human CB1r expressed in CHO cell membranes in the presence of the test compound | IC50 = 7.5 nM | Inverse agonism = 32.5% | PMID: 16263284 | |
| CNR2 | Homo sapiens | Radioligand Binding Assay (CNR2): Measurement of the reduction in binding of [3H]CP-55940 (a hCB1r agonist) to recombinant human CB1r expressed in CHO cell membranes in the presence of the test compound | IC50 = 4627 nM | Inverse agonism = 38.3% | PMID: 16263284 |
In cell potency
| Target name | Target information | Species | Assay description | MRL-650 | MRL-CB1-NC | Publication of assay conditions |
|---|---|---|---|---|---|---|
| CNR1 | recombinant hCNR1 CHO cells | Homo sapiens | Functional activation assay | EC50 = 4.9 nM |