Potency data for probe WM-1119 and control WM-2474
In vitro potency
| Target name | Target information | Species | Assay description | WM-1119 | WM-2474 | Publication of assay conditions |
|---|---|---|---|---|---|---|
| METAP2, KAT6A | Homo sapiens | Biochemical activity-MetAP2 using Co | IC50 = 37 nM | IC50 > 50 µM | PMID: 22086725 | |
| METAP2, KAT6A | Homo sapiens | Biochemical activity-MetAP2 using Mn | Kd = 2 nM | PMID: 30069049 |
In cell potency
| Target name | Target information | Species | Assay description | Compound conc. | WM-1119 | WM-2474 | Publication of assay conditions |
|---|---|---|---|---|---|---|---|
| Mus musculus | Cell growth of Fucci MEFs | 1 µM | Cell cycle effect = Cell cyle arrest in G1 | Cell cycle effect = No effect on cell cycle | PMID: 30069049 | ||
| Eµ-Myc lymphoma cell line EMRK1184 | Mus musculus | Proliferation assay with EMRK1184 lymphoma cells | IC50 = 0.25 µM | PMID: 30069049 |