Selectivity data for probe WM-1119 and control WM-2474
Jump to control PDSP data
WM-1119
Compound concentration: 10 µM| Receptor | HGNC target name | Inhibition [%] (Primary experimental value) | Ki [nM] (Secondary experimental value) | pKi |
|---|---|---|---|---|
| Beta1 | ADRB1 | -0.13 | ||
| Beta3 | ADRB3 | 16.31 | ||
| GABAA/BZP | 75.65 | |||
| GABAA | 11.66 | |||
| GABA/PBR | 47.03 | |||
| D4 | DRD4 | 23.82 | ||
| D5 | DRD5 | 4.57 | ||
| H4 | HRH4 | -2.44 | ||
| KOR | OPRK1 | 5.23 | ||
| MOR | OPRM1 | 3.45 | ||
| 5-HT1B | HTR1B | 13.62 | ||
| Alpha1A | ADRA1A | 9.59 | ||
| Alpha1B | ADRA1B | 7.18 | ||
| Alpha1D | ADRA1D | 3.20 | ||
| Alpha2A | ADRA2A | -14.88 | ||
| Alpha2B | ADRA2B | -3.78 | ||
| Alpha2C | ADRA2C | 10.19 | ||
| M1 | CHRM1 | 0.14 | ||
| M2 | CHRM2 | 15.93 | ||
| M3 | CHRM3 | -17.57 | ||
| M4 | CHRM4 | 20.45 | ||
| M5 | CHRM5 | -8.87 | ||
| Sigma 2 | TMEM97 | 19.95 | ||
| 5-HT1A | HTR1A | 16.03 | ||
| 5-HT1D | HTR1D | -0.66 | ||
| 5-HT1E | HTR1E | 13.84 | ||
| 5-HT2A | HTR2A | -7.37 | ||
| 5-HT2B | HTR2B | 2.94 | ||
| 5-HT6 | HTR6 | -20.19 | ||
| 5-HT7A | HTR7 | -3.75 | ||
| D1 | DRD1 | -3.67 | ||
| D2 | DRD2 | 79.62 | 397.52 average (n=2) | 6.41 |
| D3 | DRD3 | 4.97 | ||
| 5-HT2C | HTR2C | 6.46 | ||
| 5-HT3 | HTR3A | 32.85 | ||
| 5-HT5A | HTR5A | -9.77 | ||
| Beta2 | ADRB2 | 13.19 | ||
| DAT | SLC6A3 | -27.13 | ||
| DOR | OPRD1 | 20.56 | ||
| H1 | HRH1 | -8.33 | ||
| H2 | HRH2 | 5.32 | ||
| H3 | HRH3 | -20.48 | ||
| NET | SLC6A2 | -15.50 | ||
| SERT | SLC6A4 | -16.72 | ||
| Sigma 1 | SIGMAR1 | 35.74 |
WM-2474
Compound concentration: 10 µM| Receptor | HGNC target name | Inhibition [%] (Primary experimental value) | Ki [nM] (Secondary experimental value) | pKi |
|---|---|---|---|---|
| Alpha1B | ADRA1B | -3.44 | ||
| 5-HT1B | HTR1B | 11.01 | ||
| 5-HT1D | HTR1D | -15.02 | ||
| 5-HT1A | HTR1A | 23.05 | ||
| M2 | CHRM2 | -5.57 | ||
| 5-HT2A | HTR2A | 11.82 | ||
| 5-HT2B | HTR2B | 40.09 | ||
| Alpha1A | ADRA1A | 18.65 | ||
| Alpha1D | ADRA1D | 17.43 | ||
| Beta1 | ADRB1 | 11.19 | ||
| Beta2 | ADRB2 | 10.38 | ||
| D1 | DRD1 | 8.58 | ||
| D3 | DRD3 | -8.61 | ||
| D5 | DRD5 | 5.79 | ||
| GABAA | 4.55 | |||
| H1 | HRH1 | -2.04 | ||
| H2 | HRH2 | -5.93 | ||
| H3 | HRH3 | 15.52 | ||
| H4 | HRH4 | -19.80 | ||
| M1 | CHRM1 | 43.34 | ||
| M3 | CHRM3 | 12.97 | ||
| M4 | CHRM4 | -11.78 | ||
| M5 | CHRM5 | -10.56 | ||
| NET | SLC6A2 | -2.40 | ||
| GABA/PBR | -3.60 | |||
| 5-HT1E | HTR1E | 13.10 | ||
| 5-HT2C | HTR2C | 7.81 | ||
| 5-HT3 | HTR3A | 4.55 | ||
| 5-HT5A | HTR5A | -0.06 | ||
| 5-HT6 | HTR6 | 2.65 | ||
| 5-HT7A | HTR7 | -1.87 | ||
| Alpha2A | ADRA2A | 68.51 | > 10000.00 average (n=2) | < 5.00 |
| Alpha2B | ADRA2B | 3.07 | ||
| Alpha2C | ADRA2C | -5.42 | ||
| Beta3 | ADRB3 | -12.02 | ||
| GABAA/BZP | 34.61 | |||
| D2 | DRD2 | 14.72 | ||
| D4 | DRD4 | 9.83 | ||
| DAT | SLC6A3 | 80.15 | > 10000.00 average (n=2) | < 5.00 |
| DOR | OPRD1 | 7.99 | ||
| KOR | OPRK1 | -5.10 | ||
| MOR | OPRM1 | 26.08 | ||
| SERT | SLC6A4 | 6.15 | ||
| Sigma 1 | SIGMAR1 | 19.11 | ||
| Sigma 2 | TMEM97 | 40.13 |